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Fleet Pain-Relief (Generic Pramoxine)

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Why is this medication prescribed?

Pramoxine is used to treat minor wounds, scrapes, burns, minor skin irritation or rashes, dry, itchy skin, poison ivy, poison oak, and poison sumac for a short period of time. Pramoxine may also be used to treat minor rectal irritations or itching, as well as soreness, burning, itching, and pain from hemorrhoids (commonly known as “piles”). The drug pramoxine belongs to the group of drugs known as topical anesthetics. It functions by preventing nerves from transmitting pain impulses.

How should this medicine be used?

Pramoxine is available as a skin-applying gel or spray. Pramoxine can also be applied to the rectal area as a cream, foam, lotion, or solution (liquid). Individual pledgets, or medicated wipes for a single use, are the solution. The afflicted area is often treated with pramoxine many times per day. Pramoxine cream, pledgets, or gel may be applied up to five times per day; spray or pledgets may be applied three to four times per day. After bowel movements, you can use Pramoxine hemorrhoidal cream, lotion, or foam as needed or advised. Ask your doctor or pharmacist to explain any instructions you do not understand, and carefully follow any instructions on the packaging or on the label of your prescription. Use pramoxin as prescribed by your doctor. Use the medication just as directed on the container or as directed by your doctor. Do not use more, less, or it more frequently or for a longer period of time.

Stop using pramoxine and contact your doctor if your symptoms last more than seven days, if your condition worsens, or if it improves for a few days before returning.

Avoid getting pramoxine in your nose or eyes. Call your doctor and rinse your eyes if pramoxin gets in them.

Pramoxine should not be applied to open wounds, blistered or damaged skin, deep wounds, or huge areas. After applying pramoxine, avoid using bandages or wraps unless your doctor instructs you to.

Never use your fingers or any other implements to insert wet prescription pads, creams, gels, or foam into your rectum.

Follow these instructions to apply pramoxine cream, gel, spray, or lotion:

  1. Sanitize your hands.
  2. Use warm water and mild soap to wash the afflicted area. Thoroughly rinse.
  3. With a clean, gentle cloth or tissue, gently pat the affected area dry.
  4. Pramoxine should be applied sparingly to the afflicted region.
  5. Wash your hands completely.

Take the following actions to use pramoxine pledgets:

  1. Sanitize your hands.
  2. Use warm water and mild soap to wash the affected area of the rectal area. Thoroughly rinse.
  3. Pat or blot the area dry with a soft, clean towel or tissue.
  4. Take the pledge out of the sealed pouch.
  5. By gently patting the injured rectal area, administer medication from pledget. Pledget can be folded if necessary and left in place for up to 15 minutes.
  6. Remove the vow and discard it far away from youngsters.
  7. Clean your hands completely.

Use pramoxin hemorrhoidal foam by performing the following actions:

  1. Sanitize your hands.
  2. Use warm water and mild soap to wash the afflicted area. Thoroughly rinse.
  3. Pat or blot the area dry with a soft, clean towel or tissue.
  4. Shake the can of foam.
  5. Apply a small amount of foam to the afflicted area of the rectal cavity using a clean tissue.
  6. Clean your hands completely.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using pramoxine,

  • If you have an allergy to pramoxine, any other topical anesthetics, or any other drug, tell your doctor right away.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are using.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you get pregnant while taking pramoxine.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

As soon as you realize you missed a dose, administer it. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. Applying a second dose to make up for a missed one is not advised.

What side effects can this medication cause?

Pramoxine might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Redness, itchiness, swelling, discomfort, burning, or stinging at the afflicted area
  • The afflicted area is dry

Some adverse effects can be very harmful. Even though the following signs are unusual, you should call your doctor right away if you notice any of them:

  • Bleeding in the injured area
  • Hives
  • Body rash
  • Intense itch
  • Breathing or swallowing challenges
  • Edema of the hands, feet, ankles, lower legs, cheeks, neck, tongue, lips, and eyes
  • Hoarseness

Other negative effects of pramoxin are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. Keep the aerosol, lotion, spray, or bottle of pramoxin away from heat sources like fire or flame. Containers for pramoxin aerosol should not be burned.

To make sure that pets, kids, and other people cannot take leftover pharmaceuticals, they should be disposed of in a specific manner. You shouldn’t flush this medication down the toilet, though. The best option to get rid of your medication is instead through a medication take-back program. To find out about take-back initiatives in your neighborhood, speak with your pharmacist or get in touch with your city’s waste/recycling department. If you do not have access to a take-back program, you can find more information at the FDA’s Safe Disposal of Medicines website (

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments.

You can ask any questions you have about pramoxine to your pharmacist or doctor.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Fleet® Pain-Relief
  • Itch-X®
  • PrameGel®
  • Prax®
  • Tronolane®
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