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Firazyr (Generic Icatibant injection)

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Why is this medication prescribed?

Firazyr is a medication prescribed for the treatment of acute attacks of hereditary angioedema (HAE) in adults, adolescents, and children aged 2 years and older. Hereditary angioedema is a rare genetic disorder characterized by episodes of severe swelling in various parts of the body, including the hands, feet, face, abdomen, and throat. These attacks can be painful and potentially life-threatening, particularly if they affect the airway.

Firazyr contains the active ingredient icatibant, which is a selective bradykinin B2 receptor antagonist. Bradykinin is a substance in the body that can contribute to the development of swelling in HAE attacks. By blocking the effects of bradykinin, Firazyr helps to reduce the severity and duration of HAE attacks.

How should this medicine be used?

Firazyr (icatibant) is typically used to treat acute attacks of hereditary angioedema (HAE) in adults, adolescents (aged 12 years and older), and children (aged 2 years and older). Here are the general guidelines for using Firazyr:

  • Administration: Firazyr is administered as a subcutaneous injection, which means it is injected under the skin. It should be injected into the fatty tissue of the abdomen (stomach area) or thigh.
  • Dosage: The recommended dose of Firazyr for adults and adolescents (aged 12 years and older) is 30 mg, administered as a single subcutaneous injection. For children aged 2 to 12 years, the dose is based on body weight, with a maximum dose of 30 mg.
  • Timing: Firazyr should be administered as soon as possible after the onset of symptoms of an acute HAE attack. It is most effective when given early in the attack.
  • Self-administration: Some patients may be trained to self-administer Firazyr injections. Healthcare professionals can provide instructions on proper injection technique and monitoring for adverse reactions.
  • Medical supervision: While Firazyr can be self-administered in certain cases, it’s essential to seek medical attention immediately after using it to manage an acute HAE attack. This ensures proper evaluation and monitoring, as well as potential follow-up treatment if necessary.
  • Follow-up: After using Firazyr, patients should follow up with their healthcare provider for further evaluation and management of their HAE condition. It’s essential to discuss the frequency of attacks and any changes in symptoms to adjust treatment as needed.

Always follow the specific instructions provided by your healthcare provider for the proper use of Firazyr, including dosage, administration technique, and any precautions or warnings. Never hesitate to ask questions if you’re unsure about how to use the medication correctly.

Other uses for this medicine

Firazyr is primarily indicated for the treatment of HAE attacks and should not be used for other conditions unless prescribed by a healthcare professional. Its mechanism of action, targeting the bradykinin B2 receptor, is specific to treating HAE attacks.

What special precautions should I follow?

Special precautions to follow when using Firazyr include:

  • Allergy: Inform your healthcare provider if you are allergic to icatibant or any other ingredients in Firazyr. Allergic reactions to Firazyr are rare but can occur.
  • Pregnancy and breastfeeding: The safety of Firazyr during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Firazyr with your healthcare provider before using it.
  • Injection site reactions: Injection site reactions, such as redness, swelling, itching, or pain, may occur after administering Firazyr. Rotate injection sites and monitor for any signs of irritation or infection.
  • Medication interactions: Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements. Some medications may interact with Firazyr, affecting its effectiveness or increasing the risk of side effects.
  • Blood clotting disorders: Use caution when administering Firazyr to patients with a history of blood clotting disorders or those taking anticoagulant medications, as Firazyr may increase the risk of bleeding.
  • Driving and operating machinery: Firazyr may cause dizziness or drowsiness in some individuals. Avoid driving, operating heavy machinery, or engaging in activities that require mental alertness until you know how Firazyr affects you.
  • Children and elderly: The safety and effectiveness of Firazyr have not been established in children under 2 years of age or in elderly patients (aged 65 years and older). Use caution when prescribing Firazyr in these populations.

It’s essential to follow your healthcare provider’s instructions carefully when using Firazyr and to report any adverse reactions or concerns promptly. If you have questions about the use of Firazyr or its precautions, consult your healthcare provider for personalized guidance.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are no specific dietary restrictions associated with Firazyr. However, it’s essential to maintain a healthy and balanced diet as recommended by your healthcare provider to support overall health and well-being.

What should I do if I forget a dose?

If you forget a dose of Firazyr, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If you have questions or concerns about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Firazyr (icatibant) can cause side effects, although not everyone experiences them. Some common side effects of Firazyr include:

  • Injection site reactions: Redness, swelling, itching, or pain at the injection site are common side effects of Firazyr. These reactions are usually mild to moderate in severity and resolve on their own within a few hours to days.
  • Headache: Headache is a common side effect of Firazyr treatment. It is usually mild to moderate in intensity and transient.
  • Nausea: Some individuals may experience nausea after receiving Firazyr injections.
  • Dizziness: Dizziness or lightheadedness may occur in some patients after using Firazyr.
  • Fatigue: Feeling tired or fatigued is a possible side effect of Firazyr treatment.
  • Injection site bruising: Bruising at the injection site may occur in some individuals.
  • Diarrhea: Diarrhea has been reported as a side effect of Firazyr, although it is not very common.
  • Fever: Some patients may experience fever after receiving Firazyr injections.
  • Allergic reactions: Although rare, allergic reactions to Firazyr can occur. Symptoms of an allergic reaction may include rash, itching, swelling of the face, lips, tongue, or throat, difficulty breathing, or severe dizziness. Seek immediate medical attention if you experience any signs of an allergic reaction.

It’s essential to report any side effects you experience while using Firazyr to your healthcare provider. Additionally, if you have any concerns about potential side effects or if you experience severe or persistent side effects, seek medical attention promptly.

What should I know about storage and disposal of this medication?

Storage and disposal of Firazyr:

  • Storage: Firazyr should be stored in its original packaging at room temperature, away from light and moisture. Do not freeze. Keep Firazyr out of reach of children and pets.
  • Disposal: Dispose of used Firazyr injection devices properly according to local regulations or as instructed by your healthcare provider or pharmacist. Do not dispose of Firazyr in household waste or down the drain unless specifically instructed to do so.

In case of emergency/overdose

In case of emergency or overdose of Firazyr:

  • If you suspect an overdose of Firazyr or experience severe side effects such as difficulty breathing, severe dizziness, or loss of consciousness, seek immediate medical attention or contact your local poison control center.
  • Provide healthcare providers with as much information as possible, including the amount of Firazyr taken and any other medications or substances that may have been ingested.

What other information should I know?

  • Follow your healthcare provider’s instructions carefully for the proper administration and dosing of Firazyr.
  • Keep track of your Firazyr injections and report any changes in symptoms or the frequency of HAE attacks to your healthcare provider.
  • Attend all scheduled appointments with your healthcare provider for monitoring and evaluation of your HAE condition.
  • Inform your healthcare provider about any other medical conditions you have, especially if you have a history of blood clotting disorders or allergies.
  • Inform your healthcare provider about all medications you are taking, including prescription, over-the-counter, and herbal supplements, as some medications may interact with Firazyr.
  • If you have any questions or concerns about Firazyr or its use, consult your healthcare provider or pharmacist for more information and guidance.

Remember, Firazyr is prescribed specifically for the treatment of acute attacks of hereditary angioedema (HAE) and should not be used for other conditions unless directed by your healthcare provider.

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