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Fexofenadine and Pseudoephedrine

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Why is this medication prescribed?

Fexofenadine and pseudoephedrine are commonly prescribed together as a combination medication to relieve symptoms of allergic rhinitis (hay fever) and nasal congestion. Fexofenadine is an antihistamine that works by blocking the effects of histamine, a substance in the body that causes allergy symptoms such as sneezing, itching, watery eyes, and runny nose. Pseudoephedrine is a decongestant that works by narrowing the blood vessels in the nasal passages, reducing swelling and congestion. These medications are typically used to relieve symptoms associated with seasonal allergies, such as sneezing, itching, runny or stuffy nose, and sinus congestion.

How should this medicine be used?

Fexofenadine and pseudoephedrine are commonly used together to treat symptoms of allergies and the common cold. Here’s how they are typically used:

  • Dosage: Follow the dosage instructions provided by your healthcare provider or as indicated on the medication packaging. Dosage can vary depending on factors such as age, weight, and severity of symptoms.
  • Frequency: Take the medication as directed by your healthcare provider. Typically, it’s taken once or twice daily, but this can vary.
  • Administration: Fexofenadine and pseudoephedrine are usually taken orally with water. They are available in tablet form.
  • Timing: Take the medication at the same time each day to maintain a consistent level in your bloodstream and maximize its effectiveness.
  • Food: Fexofenadine can be taken with or without food. However, pseudoephedrine may be more effective if taken on an empty stomach, as food can decrease its absorption.
  • Duration: Use the medication for the full prescribed length of time, even if your symptoms improve before then. Stopping too early may allow symptoms to return.
  • Caution: Do not exceed the recommended dosage. Taking too much of either medication can lead to serious side effects.
  • Medical Advice: Consult your healthcare provider before starting or stopping any medication, especially if you have underlying medical conditions or are taking other medications.

Always read the label and package insert for specific instructions and precautions. If you have any questions or concerns about using fexofenadine and pseudoephedrine, consult your healthcare provider or pharmacist for guidance.

Other uses for this medicine

Off-label uses may include:

  • Relief of symptoms associated with sinusitis (inflammation of the sinuses).
  • Management of symptoms related to colds and upper respiratory tract infections.
  • Alleviation of symptoms of allergic conjunctivitis (eye allergies).
  • Treatment of urticaria (hives) and itching associated with various skin conditions.

What special precautions should I follow?

Special precautions should be taken when using Fexofenadine and Pseudoephedrine combination medication. Some key precautions include:

  • Inform your healthcare provider about any allergies you have, especially if you are allergic to Fexofenadine, pseudoephedrine, or any other medications.
  • Disclose your medical history, including any pre-existing conditions such as high blood pressure, heart disease, diabetes, thyroid disorders, glaucoma, prostate problems, kidney disease, liver disease, or difficulty urinating (due to an enlarged prostate).
  • Limit the use of alcohol while taking these medications, as it may exacerbate certain side effects.
  • Avoid using Fexofenadine and Pseudoephedrine if you are taking monoamine oxidase inhibitors (MAOIs) or have taken them within the last 14 days, as this combination may lead to severe reactions.
  • Pregnant or breastfeeding individuals should consult their healthcare provider before using Fexofenadine and Pseudoephedrine, as the safety of these medications during pregnancy and lactation has not been fully established.
  • Elderly individuals may be more sensitive to the side effects of Fexofenadine and Pseudoephedrine, such as dizziness, drowsiness, and increased blood pressure. Caution is advised in this population.

Always follow your healthcare provider’s instructions and guidelines when using Fexofenadine and Pseudoephedrine combination medication, and report any adverse reactions or concerns promptly.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with taking Fexofenadine and Pseudoephedrine. However, it’s generally recommended to avoid taking these medications with fruit juices, as it may decrease their absorption.

What should I do if I forget a dose?

If you forget a dose of Fexofenadine and Pseudoephedrine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If you have any concerns or questions about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Fexofenadine and pseudoephedrine, like any medication, can cause side effects. Common side effects associated with the use of Fexofenadine and Pseudoephedrine combination medication may include:

  • Nervousness
  • Dizziness
  • Drowsiness
  • Headache
  • Insomnia (difficulty sleeping)
  • Dry mouth
  • Nausea
  • Upset stomach
  • Blurred vision
  • Difficulty urinating
  • Changes in appetite
  • Increased heart rate
  • Palpitations (feeling of a rapid or irregular heartbeat)
  • Tremors
  • Sweating

These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, it’s essential to inform your healthcare provider promptly.

In rare cases, Fexofenadine and Pseudoephedrine may cause more severe side effects or allergic reactions. Seek immediate medical attention if you experience any of the following:

  • Severe dizziness or fainting
  • Severe headache
  • Irregular heartbeat or chest pain
  • Difficulty breathing or wheezing
  • Swelling of the face, lips, tongue, or throat
  • Rash, itching, or hives

It’s important to note that this is not a comprehensive list of side effects. If you experience any other unusual symptoms while taking Fexofenadine and Pseudoephedrine, contact your healthcare provider or pharmacist for further evaluation and guidance.

What should I know about storage and disposal of this medication?

Storage and disposal of Fexofenadine and Pseudoephedrine:


  • Store the medication at room temperature away from moisture and heat.
  • Keep Fexofenadine and Pseudoephedrine out of reach of children and pets.
  • Do not store the medication in the bathroom or near the kitchen sink, where it could be exposed to moisture.
  • Store the medication in its original packaging or container to protect it from light and moisture.
  • Do not use expired medication. Dispose of any expired or unused medication properly.


  • Follow any specific disposal instructions provided by your pharmacist or healthcare provider.
  • Do not flush Fexofenadine and Pseudoephedrine down the toilet or pour them into a drain unless instructed to do so.
  • Dispose of the medication in accordance with local regulations for medication disposal. This may include using a drug take-back program or a designated disposal site in your community.

In case of emergency/overdose

In case of emergency or overdose of Fexofenadine and Pseudoephedrine, take the following steps:

  • If someone has overdosed and is showing serious symptoms such as difficulty breathing, seizures, or loss of consciousness, call emergency services immediately.
  • If possible, provide emergency responders with information about the medication ingested, including the dosage and time of ingestion.
  • If you suspect an overdose but the person is conscious and alert, contact a poison control center or seek medical attention immediately for guidance on next steps.
  • Do not induce vomiting unless instructed to do so by a healthcare professional.

What other information should I know?

  • Keep track of your medication usage and refill schedule to ensure you have an adequate supply on hand.
  • Inform your healthcare provider of any other medications, supplements, or herbal products you are taking, as they may interact with Fexofenadine and Pseudoephedrine.
  • Avoid driving or operating heavy machinery until you know how the medication affects you, as it may cause drowsiness or dizziness.
  • Consult your healthcare provider if your symptoms do not improve or worsen while taking Fexofenadine and Pseudoephedrine.
  • Follow up with your healthcare provider as scheduled to monitor your response to the medication and adjust your treatment plan as needed.
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