WARNING

Feraheme (ferumoxytol) is an intravenous iron replacement therapy used to treat iron deficiency anemia in adult patients with chronic kidney disease. While generally considered safe and effective, like any medication, Feraheme comes with potential risks. Here are some of the key risks associated with taking Feraheme:

• Allergic reactions: Some patients may experience allergic reactions to Feraheme, which can range from mild to severe. Symptoms may include rash, itching, difficulty breathing, swelling of the face, lips, tongue, or throat, and low blood pressure. Severe allergic reactions can be life-threatening and require immediate medical attention.
• Hypotension (low blood pressure): Feraheme can cause a sudden drop in blood pressure, especially during or immediately after the infusion. Patients may experience dizziness, lightheadedness, fainting, or feelings of weakness. Monitoring blood pressure during and after the infusion is essential to manage this risk.
• Iron overload: Feraheme administration can lead to excess iron accumulation in the body, particularly in patients with conditions such as hemochromatosis or other iron overload disorders. Regular monitoring of iron levels is necessary to prevent complications associated with iron overload, such as organ damage.
• Risk of infection: Feraheme is administered intravenously, increasing the risk of infection at the injection site. Healthcare providers must follow proper sterile techniques during administration to minimize this risk.
• Hypersensitivity reactions: In addition to allergic reactions, some patients may experience hypersensitivity reactions, including flushing, shortness of breath, chest pain, and palpitations.
• Other adverse effects: Common side effects of Feraheme may include headache, nausea, vomiting, abdominal pain, diarrhea, muscle aches, back pain, and cough.

It’s essential for patients to discuss their medical history, including any allergies or underlying health conditions, with their healthcare provider before starting Feraheme treatment. Additionally, patients should be monitored closely during and after the infusion for any signs of adverse reactions.

Why is this medication prescribed?

Feraheme (ferumoxytol) is prescribed to treat iron deficiency anemia in adult patients with chronic kidney disease (CKD). Iron deficiency anemia occurs when the body lacks enough iron to produce hemoglobin, the protein in red blood cells that carries oxygen. CKD patients are particularly at risk for iron deficiency anemia due to decreased production of erythropoietin, a hormone that stimulates red blood cell production, and other factors related to kidney dysfunction.

Feraheme works by replenishing iron stores in the body, which helps support the production of red blood cells and alleviates the symptoms of anemia, such as fatigue, weakness, and shortness of breath.

How should this medicine be used?

Feraheme is administered intravenously by a healthcare professional. The dosage and frequency of administration are determined by the patient’s iron deficiency severity and individual response to treatment. Typically, Feraheme is given as a series of injections over a period of time, with each infusion lasting about 15 minutes.

Before receiving Feraheme, patients should inform their healthcare provider about any allergies, medical conditions, or medications they are currently taking. It’s essential to follow the healthcare provider’s instructions carefully and attend all scheduled appointments for monitoring and follow-up.

Overall, Feraheme is prescribed to help improve iron levels and alleviate symptoms of iron deficiency anemia in adult patients with chronic kidney disease who cannot tolerate or have not responded to oral iron supplementation.

Other uses for this medicine

Some off-label uses include:

• Iron deficiency anemia in non-dialysis dependent CKD patients: Feraheme may be used in adult patients with CKD who are not on dialysis but have iron deficiency anemia.
• Iron deficiency anemia in patients with inflammatory bowel disease (IBD): Feraheme may be prescribed for adult patients with IBD who have iron deficiency anemia and are unable to tolerate or do not respond to oral iron supplementation.
• Iron deficiency anemia in patients with chronic heart failure: In some cases, Feraheme may be used off-label to treat iron deficiency anemia in adult patients with chronic heart failure.

What special precautions should I follow?

As for special precautions when using Feraheme, here are some key points to consider:

• Allergy and hypersensitivity: Patients should be monitored for signs of allergic reactions or hypersensitivity during and after administration of Feraheme. Individuals with known allergies to Feraheme or any of its components should not receive the medication.
• Hypotension: Feraheme can cause a sudden drop in blood pressure, especially during or immediately after infusion. Blood pressure should be monitored closely during and after administration, and appropriate measures should be taken to manage hypotension if it occurs.
• Iron overload: Regular monitoring of iron levels is important to prevent iron overload, especially in patients with conditions predisposing them to iron accumulation, such as hemochromatosis or other iron overload disorders.
• Infection risk: Feraheme is administered intravenously, increasing the risk of infection at the injection site. Healthcare providers should follow proper sterile techniques during administration to minimize this risk.
• Interactions with other medications: Patients should inform their healthcare provider about all medications they are taking, including prescription drugs, over-the-counter medications, and supplements, as certain medications may interact with Feraheme.

Overall, Feraheme should be used with caution and under the supervision of a healthcare professional who can monitor for potential adverse effects and ensure the safe and appropriate use of the medication.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Feraheme. However, it’s generally recommended to maintain a well-balanced diet rich in iron-containing foods, such as lean meats, poultry, fish, beans, lentils, tofu, fortified cereals, and leafy green vegetables. Your healthcare provider may also recommend taking Feraheme with or without food based on your individual needs.

What should I do if I forget a dose?

Since Feraheme is typically administered in a clinical setting by healthcare professionals, forgetting a dose is less likely to occur. However, if you miss an appointment for a scheduled infusion, contact your healthcare provider as soon as possible to reschedule. It’s essential to adhere to the prescribed treatment schedule to ensure optimal management of iron deficiency anemia.

What side effects can this medication cause?

Feraheme (ferumoxytol) is generally well-tolerated, but like any medication, it can cause side effects in some individuals. Common side effects of Feraheme include:

• Headache
• Nausea
• Dizziness
• Diarrhea
• Fatigue
• Injection site reactions (pain, swelling, redness)
• Itching
• Muscle or joint pain
• Abdominal pain
• Back pain

Less common but potentially serious side effects of Feraheme may include:

• Allergic reactions: Symptoms may include rash, itching, hives, difficulty breathing, swelling of the face, lips, tongue, or throat. Severe allergic reactions can be life-threatening and require immediate medical attention.
• Hypotension (low blood pressure): Feraheme can cause a sudden drop in blood pressure, especially during or immediately after infusion. Symptoms may include dizziness, lightheadedness, fainting, or feelings of weakness. Blood pressure should be monitored closely during and after treatment.
• Hypersensitivity reactions: In addition to allergic reactions, some patients may experience hypersensitivity reactions, which can include flushing, shortness of breath, chest pain, and palpitations.
• Iron overload: Feraheme administration can lead to excess iron accumulation in the body, particularly in patients with conditions predisposing them to iron overload. Symptoms of iron overload may include joint pain, fatigue, abdominal pain, and organ damage. Regular monitoring of iron levels is essential to prevent complications associated with iron overload.
• Infections: Since Feraheme is administered intravenously, there’s a risk of infection at the injection site. Symptoms of infection may include redness, swelling, warmth, or pus at the injection site. Contact your healthcare provider if you experience any signs of infection.

It’s important to report any side effects or adverse reactions to your healthcare provider promptly. They can provide guidance on managing side effects and adjust your treatment regimen if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Feraheme:

• Store Feraheme vials at room temperature, away from light and moisture.
• Keep Feraheme out of the reach of children and pets.
• Do not freeze Feraheme.
• Do not use Feraheme if the vial appears damaged or if the solution is discolored or contains particles.
• Dispose of unused or expired Feraheme properly according to local regulations or as instructed by your healthcare provider or pharmacist.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms after receiving Feraheme, such as severe allergic reactions, significant hypotension, or other serious adverse effects, seek immediate medical attention. Contact emergency services or go to the nearest emergency room for evaluation and treatment.

What other information should I know?

• Inform your healthcare provider about all medications, supplements, and medical conditions you have before receiving Feraheme.
• Attend all scheduled appointments for Feraheme infusions and follow-up visits with your healthcare provider for monitoring.
• Inform your healthcare provider if you experience any side effects or adverse reactions while receiving Feraheme.
• Follow your healthcare provider’s instructions regarding dietary restrictions, if any, and other recommendations for managing iron deficiency anemia.
• Do not share Feraheme with others, as it is prescribed specifically for your condition.
• Keep a record of your Feraheme treatments, including the dates of infusions and any side effects experienced, to discuss with your healthcare provider during follow-up appointments.

By following these guidelines, you can ensure the safe and effective use of Feraheme for the treatment of iron deficiency anemia as prescribed by your healthcare provider. If you have any questions or concerns about Feraheme or its use, consult your healthcare provider or pharmacist for further information and guidance.