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Nonsteroidal anti-inflammatory drug (NSAID) users, including those who take fenoprofen, may be more likely to experience a heart attack or stroke than non-users of these drugs. These occurrences could be fatal and could occur suddenly. For those who take NSAIDs for an extended period of time, this risk may be larger. If you have recently experienced a heart attack, avoid taking an NSAID like fenoprofen unless your doctor specifically instructs you to. Inform your doctor if you smoke, have high cholesterol, high blood pressure, or diabetes, or if you or anyone in your family has ever suffered from heart disease, a heart attack, or a stroke. If you suffer any of the following symptoms, seek emergency medical attention right away: chest pain, shortness of breath, weakness on one side or area of the body, or slurred speech.

Fenoprofen should not be taken soon before or right after having a coronary artery bypass graft (CABG; a form of cardiac surgery).

Fenoprofen and other NSAIDs have been linked to stomach or intestine ulcers, bleeding, and holes. These issues could arise anytime while receiving treatment, without any prior symptoms, and could be fatal. Long-term users of NSAIDs, older individuals, individuals in poorer health, and those who consume substantial amounts of alcohol while taking fenoprofen may be at greater risk.If you use any of the following medications, let your doctor know: Aspirin, other NSAIDs including ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and warfarin (Coumadin, Jantoven), which are anticoagulants (sometimes known as “blood thinners”); SSRIs like citalopram (Celexa), oral steroids like dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos), and antidepressants like fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), and sertraline (Zoloft); or SNRIs (serotonin norepinephrine reuptake inhibitors), which include duloxetine (Cymbalta), desvenlafaxine (Khedezla), and venlafaxine (Effexor XR). Additionally, let your doctor know if you now or previously had an ulcer, gastrointestinal bleeding, or any other bleeding disorders. Call your physician and stop taking fenoprofen if you have any of the following symptoms: stomach pain, heartburn, bloody or coffee-ground-looking vomit, blood in the stool, or dark, tarry stools.

Keep all of your appointments with your physician and the lab. In order to determine how well your body is responding to fenoprofen, your doctor will likely closely monitor your symptoms and run a number of tests. Inform your physician about your feelings so that they can prescribe the ideal dosage of medication to cure your problem with the least chance of negative side effects.

Each time you refill your prescription for fenoprofen, your doctor or pharmacist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. To obtain the Medication Guide, you can also go to the Food and Drug Administration (FDA) website ( or the manufacturer’s website.

Why is this medication prescribed?

Fenoprofen is used to treat osteoarthritis (arthritis brought on by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis brought on by swelling of the lining of the joints) pain, soreness, swelling, and stiffness. Additionally, fenoprofen is used to treat other types of mild to moderate pain. Fenoprofen belongs to the group of drugs known as NSAIDs. It functions by halting the body’s production of a chemical responsible for inflammation, fever, and discomfort.

How should this medicine be used?

Fenoprofen is available as a tablet and a capsule for oral consumption. For arthritis, it is typically given with a full glass of water three or four times a day, or as needed every four to six hours for discomfort. To lessen gastrointestinal disturbance, fenoprofen can be taken with food or milk. To lessen stomach distress, your doctor might also advise you to take fenoprofen together with an antacid. If you frequently use fenoprofen, take it at roughly the same time each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Fenoprofen should be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by a doctor.

Your symptoms may start to get better within a few days if you are taking fenoprofen to treat arthritis symptoms. You might not experience the full benefits of fenoprofen for two to three weeks or longer.

Other uses for this medicine

Fenoprofen is also used to treat gouty arthritis, which causes attacks of extremely painful and swollen joints due to the accumulation of certain substances in the joints, and ankylosing spondylitis, an arthritis that mostly affects the spine. The reduction of fever is another use for it. Discuss the dangers of using this drug to treat your disease with your doctor.

Ask your doctor or pharmacist for more details if you’re interested in using this drug for any other conditions.

What special precautions should I follow?

Before taking fenoprofen,

  • Inform your physician and pharmacist if you have any allergies to fenoprofen, aspirin, other NSAIDs including ibuprofen (Advil, Motrin), naproxen (Aleve), or any of the inactive components in fenoprofen capsules or tablets. For a list of the inactive components, ask your pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Mention the drugs in the IMPORTANT WARNING section as well as any of the following: Drugs that inhibit the angiotensin-converting enzyme (ACE), such as benazepril (Lotensin, in Lotrel); moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, and lisinopril (in Zestoretic), angiotensin receptor blockers (ARBs), such as azilsartan (Edarbi, in Edarbyclor), ramipril (Altace), and trandolapril (Mavik, in Tarka), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), atenolol (Tenormin, Tenoretic), telmisartan (Micardis, Micardis HCT, Twynsta), and valsartan (Exforge HCT) are beta blockers. nadolol (Corgard, in Corzide), propranolol (Hemangeol, Inderal, Innopran), metoprolol (Lopressor, Toprol XL, in Dutoprol), and labetalol (Trandate); diuretics (‘water pills’); lithium (Lithobid); oral diabetic medicines, methotrexate (Otrexup, Rasuvo, Trexall), phenobarbital, phenytoin (Dilantin, Phenytek), and sulfa antibiotics such sulfamethoxazole and sulfisoxazole (in Bactrim, in Septra). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • A hearing impairment, heart failure, swelling of the hands, feet, ankles, or lower legs, nasal polyps (swelling of the nose lining), anemia (blood cells do not bring enough oxygen to all parts of the body), liver disease, or kidney disease should also be mentioned to your doctor if you have or have ever had any of the conditions listed in the IMPORTANT WARNING section or if you have asthma. This is especially true if you also frequently stuff or run your nose.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. If fenoprofen is consumed beyond 20 weeks of pregnancy, it may harm the fetus and complicate delivery. Fenoprofen should not be taken during or after the first 20 weeks of pregnancy unless your doctor specifically instructs you to. Call your doctor if you become pregnant while taking fenoprofen.
  • If you are 75 years of age or older, discuss the advantages and disadvantages of taking fenoprofen with your doctor. Never use this medication for a longer time or at a higher dose than what is suggested by the manufacturer or your physician.
  • Inform your doctor or dentist that you are taking fenoprofen if you are undergoing surgery, including dental surgery.
  • You should be aware that this medication might make you sleepy. Until you are certain of how this medication affects you, do not operate machinery or drive a car.
  • Keep in mind that drinking can exacerbate the effects of this drug’s sedation. If you are using this medication, avoid drinking alcohol.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Side effects are possible with fenoprofen. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Nervousness
  • Drowsiness
  • Sweating
  • Constipation
  • Hearing ringing

Some adverse effects can be very harmful. Call your doctor right away if you have any of the following symptoms or those listed in the IMPORTANT WARNING section. Fenoprofen should not be taken again until you have spoken to your doctor.

  • Fuzzy vision
  • Region of your body that you are unable to control shakes
  • Rise in weight without cause
  • Respiratory issues or lack of breath
  • Abdomen, ankles, foot, or leg swelling
  • Fever
  • Blisters
  • Rash
  • Itching
  • Hives
  • Swelling of the lower legs, hands, arms, feet, ankles, or lower face, lips, tongue, throat, or eyes
  • Hoarseness
  • Breathing or swallowing challenges
  • Eyes or skin that have a yellow tint
  • Extreme fatigue
  • Uncommon bruising or bleeding
  • Not enough energy
  • Uneasy stomach
  • Reduced appetite
  • Stomach ache in the top right corner
  • Flu-like signs
  • Light skin
  • Hammering or rapid heartbeat
  • Urine that is hazy, discolored, or bloody
  • Back ache
  • Uncomfortable or challenging urinating

Other negative effects of fenoprofen are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

To make sure that pets, kids, and other people cannot take leftover pharmaceuticals, they should be disposed of in a specific manner. You shouldn’t flush this medication down the toilet, though. The best option to get rid of your medication is instead through a medication take-back program. To find out about take-back initiatives in your neighborhood, speak with your pharmacist or get in touch with your city’s waste/recycling department. If you do not have access to a take-back program, you can find more information at the FDA’s Safe Disposal of Medicines website (

In case of emergency/overdose

Call 1-800-222-1222 to reach the poison control hotline in the event of an overdose. You can get information online at Call emergency services at 911 right away if the sufferer has fallen, experienced a seizure, is having problems breathing, or cannot be roused.

Overdose symptoms could include:

  • Heartburn
  • Nausea
  • Vomiting
  • Abdominal pain
  • Dizziness
  • Shakiness or trouble balancing
  • Headache
  • Hearing ringing
  • Region of your body that you are unable to control shakes
  • Drowsiness
  • Confusion

What other information should I know?

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Nalfon®
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