Nonsteroidal anti-inflammatory drugs (NSAIDs) other than aspirin, such piroxicam, may increase the risk of a heart attack or stroke compared to those who do not take them. These occurrences could be fatal and could occur suddenly. For those who take NSAIDs for an extended period of time, this risk may be larger. If you have recently experienced a heart attack, avoid taking an NSAID like piroxicam unless your doctor specifically instructs you to. Inform your doctor if you smoke, have high cholesterol, high blood pressure, or diabetes, or if you or anyone in your family has ever suffered from heart disease, a heart attack, or a stroke. If you suffer any of the following symptoms, seek emergency medical attention right away: chest pain, shortness of breath, weakness on one side or area of the body, or slurred speech.

You shouldn’t take piroxicam soon before or right after having coronary artery bypass graft surgery (CABG; a form of cardiac surgery).

NSAIDs, including piroxicam, can result in stomach or intestine ulcers, bleeding, or holes. These issues can arise at any point during therapy, without any prior symptoms, and they have the potential to be fatal. If you take NSAIDs frequently, are older, are in poorer health, or consume a lot of alcohol while taking piroxicam, your risk may be higher. If you use any of the following medications, let your doctor know: Aspirin, other NSAIDs including ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and warfarin (Coumadin, Jantoven), which are anticoagulants (sometimes known as “blood thinners”); SSRIs like citalopram (Celexa), oral steroids like dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos), and antidepressants like fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), and sertraline (Zoloft); or SNRIs (serotonin norepinephrine reuptake inhibitors), which include duloxetine (Cymbalta), desvenlafaxine (Khedezla), and venlafaxine (Effexor XR). Additionally, let your doctor know if you currently have or have ever had stomach or intestinal bleeding, ulcers, or any other bleeding disorders. Call your physician and stop taking piroxicam immediately if you have any of the following symptoms: stomach pain, heartburn, vomiting of a bloody or coffee-ground-like substance, blood in the stool, or dark, tarry stools.

Keep all of your appointments with your physician and the lab. In order to determine how your body is responding to piroxicam, your doctor will likely closely monitor your symptoms and run a number of tests. Inform your physician about your feelings so that they can prescribe the ideal dosage of medication to cure your problem with the least chance of negative side effects.

When you start taking piroxicam and every time you refill your prescription, your doctor or pharmacist will give you the medication guide provided by the manufacturer. If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

In order to treat osteoarthritis (arthritis brought on by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis brought on by swelling of the lining of the joints), piroxicam is utilized. Piroxicam is a member of the NSAID drug class. It functions by halting the body’s production of a chemical responsible for inflammation, fever, and discomfort.

Piroxicam is available as a pill to be swallowed. Typically, it is taken once or twice a day. Take piroxicam every day at roughly the same time(s). Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the piroxicam directions exactly. Never take it in larger or less amounts or more frequently than directed by your doctor.

Piroxicam will assist in managing your symptoms but won’t treat your illness. Before you experience the full benefits of piroxicam, it could take up to 12 weeks.

Piroxicam is also occasionally used to treat ankylosing spondylitis, a kind of arthritis that mostly affects the spine, and gouty arthritis, which are bouts of intense joint pain and swelling brought on by the accumulation of certain substances in the joints. It is also occasionally used to treat menstruation pain, pain from surgery, and pain during childbirth as well as muscle discomfort and edema. The dangers of using this drug for your illness should be discussed with your doctor.

Before taking piroxicam,

• Inform your physician and pharmacist if you have any drug allergies, including those to piroxicam, aspirin, other NSAIDs including ibuprofen (Advil, Motrin), naproxen (Aleve), or any of the inactive chemicals in piroxicam capsules. Request a list of the inactive ingredients from your pharmacist.
• Inform your physician and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are currently taking or intend to use. Make careful to bring up any of the following, along with any of the medications indicated in the IMPORTANT WARNING section: Benazepril (Lotensin, in Lotrel), captopril, and other angiotensin-converting enzyme (ACE) inhibitors, enalapril, fosinopril, lisinopril (in Zestoretic), ramipril (in Altace), perindopril (in Aceon, in Prestalia), quinapril (in Accupril, in Quinaretic), and trandolapril (in Mavik, in Tarka); angiotensin receptor blockers (ARBs) include eprosartan (Teveten), candesartan (Atacand, in Atacand HCT), azilsartan (Edarbi, in Edarbyclor), irbesartan (Avapro, in Avalide), and etosartan (Teveten), telmisartan (Micardis, in Micardis HCT, in Twynsta), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), and valsartan (in Exforge HCT); beta blockers such nadolol (Corgard, in Corzide), propranolol (Hemangeol, Inderal, Innopran), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), and atenolol (Tenormin, in Tenoretic); ‘Water pills’, methotrexate (Otrexup, Rasuvo, Trexall), lithium (Lithobid), diabetic drugs, phenytoin (Dilantin, Phenytek), and diuretics (water pills). Your physician might need to adjust the dosage of your medication or keep a closer eye on you for adverse effects.
• Inform your doctor if you have or have ever had asthma, especially if you also suffer from chronic sinusitis, a persistent runny or stuffy nose, nasal polyps (swelling of the nasal lining), heart failure, edema of the hands, feet, ankles, or lower legs, or liver or kidney illness.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. If piroxicam is consumed after 20 weeks of pregnancy, it may harm the fetus and complicate delivery. Piroxicam should not be taken during or after the first 20 weeks of pregnancy unless your doctor specifically instructs you to. Call your doctor if you become pregnant while taking piroxicam.
• If you are 75 years of age or older, discuss the advantages and disadvantages of taking piroxicam with your doctor. Never use this medication for a longer time or at a greater dose than what your doctor has prescribed.
• Inform your doctor or dentist that you are taking piroxicam if you are having surgery, including dental surgery.

Keep eating normally unless your doctor instructs you otherwise.

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

Side effects are possible with piroxicam. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Diarrhea
• Constipation
• Gas
• Headache
• Dizziness
• Hearing ringing

Some adverse effects can be very harmful. Call your doctor right away if you have any of the following symptoms or those listed in the IMPORTANT WARNING section. Till you have a consultation with your doctor, stop taking piroxicam.

• Vision problems
• Unexplained weight gain
• Shortness of breath or difficulty breathing
• Swelling in the abdomen, ankles, feet, or legs
• Fever
• Blisters
• Joint pain
• Rash
• Itching
• Hives
• Swelling of the eyes, face, lips, tongue, throat, arms, or hands
• Difficulty breathing or swallowing
• Hoarseness
• Pale skin
• Fast heartbeat
• Excessive tiredness
• Unusual bleeding or bruising
• Lack of energy
• Upset stomach
• Loss of appetite
• Pain in the upper right part of the stomach
• Flu-like symptoms
• Yellowing of the skin or eyes
• Cloudy, discolored, or bloody urine
• Back pain
• Difficult or painful urination

Other negative effects of piroxicam are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088 if you have a serious side event.

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.http://www.upandaway.org

To make sure that pets, kids, and other people cannot take leftover pharmaceuticals, they should be disposed of in a specific manner. You shouldn’t flush this medication down the toilet, though. The best option to get rid of your medication is instead through a medication take-back program. To find out about take-back initiatives in your neighborhood, speak with your pharmacist or get in touch with your city’s waste/recycling department. If you do not have access to a take-back program, you can find more information at the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p).

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

• Not enough energy
• Drowsiness
• Uneasy stomach
• Vomiting
• Abdominal pain
• Tarry, dark, or bloody stools
• Vomiting something that looks like coffee grounds or is bloody
• Having trouble breathing
• Coma (a temporary loss of consciousness)

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.