WARNING

Evusheld is a monoclonal antibody therapy used to prevent COVID-19 in certain high-risk individuals. Like any medication, it carries potential risks and side effects. Common side effects may include injection site reactions, fever, fatigue, headache, muscle aches, and nausea.

However, there are some more serious risks associated with Evusheld, including allergic reactions, which can be severe and require immediate medical attention. Additionally, there is a theoretical risk of the antibody treatment interfering with the body’s ability to mount a natural immune response to future infections.

It’s important for individuals considering Evusheld to discuss the potential risks and benefits with their healthcare provider, especially if they have a history of allergies or other medical conditions.

Why is this medication prescribed?

Evusheld is a prescription medication used for pre-exposure prophylaxis (PrEP) to prevent COVID-19 in individuals who are at high risk of exposure to the SARS-CoV-2 virus. It is specifically designed for adults and adolescents aged 12 years and older who have weakened immune systems due to medical conditions or medications.

Evusheld is a combination of two monoclonal antibodies, tixagevimab and cilgavimab, which work by neutralizing the SARS-CoV-2 virus and preventing it from infecting cells.

How should this medicine be used?

Evusheld is typically administered as a subcutaneous injection, which means it is injected under the skin. The injection is usually given in the abdomen, thigh, or upper arm.

Here are the general steps for administering Evusheld:

• Preparation: Wash your hands thoroughly with soap and water. Gather all the supplies you will need, including the Evusheld injection kit, alcohol wipes, and a sharps disposal container.
• Check the medication: Inspect the Evusheld vial for any signs of damage or contamination. Make sure the liquid is clear and free from particles. Do not use the medication if it appears discolored or if there are any particles present.
• Preparation of the injection site: Clean the injection site with an alcohol wipe and allow it to dry completely. This helps reduce the risk of infection.
• Prepare the injection: If instructed by your healthcare provider, you may need to mix the contents of the Evusheld vial with a diluent provided in the kit. Follow the specific instructions provided with the medication for proper mixing.
• Draw up the medication: Use a syringe and needle provided in the kit to draw up the prescribed dose of Evusheld from the vial. Remove any air bubbles from the syringe by gently tapping it and pushing the plunger until all air is expelled.
• Administer the injection: Pinch the skin at the injection site and insert the needle at a 45 to 90-degree angle. Inject the medication slowly and steadily. Once the injection is complete, remove the needle and apply gentle pressure to the injection site with a clean cotton ball or gauze.
• Disposal: Safely dispose of the used needle and syringe in a sharps disposal container according to local regulations. Do not reuse needles or syringes.
• Storage: Store any unused Evusheld vials and supplies according to the manufacturer’s instructions. Keep the medication refrigerated and protect it from light.

Always follow the specific instructions provided by your healthcare provider and the medication’s packaging. If you have any questions or concerns about how to use Evusheld, don’t hesitate to consult your healthcare provider or pharmacist for guidance.

Other uses for this medicine

Evusheld is specifically indicated for pre-exposure prophylaxis (PrEP) to prevent COVID-19 in individuals who are at high risk of exposure to the SARS-CoV-2 virus. It is not intended for other uses. However, it’s essential to discuss any concerns or questions about Evusheld with your healthcare provider.

What special precautions should I follow?

When using Evusheld, there are several special precautions to keep in mind:

• Allergies: Inform your healthcare provider if you have any known allergies to tixagevimab, cilgavimab, or any other ingredients in Evusheld. Allergic reactions to monoclonal antibody medications can occur and may require immediate medical attention.
• Infections: Evusheld may not be suitable for individuals with active infections. Your healthcare provider will evaluate your current health status before prescribing Evusheld.
• Immunocompromised individuals: Evusheld is specifically indicated for individuals who have weakened immune systems due to medical conditions or medications. However, the effectiveness of Evusheld may vary depending on the degree of immunosuppression. Discuss with your healthcare provider if you have concerns about your immune status.
• Interactions with other medications: Inform your healthcare provider about all prescription and over-the-counter medications, vitamins, and supplements you are taking, as they may interact with Evusheld. Your healthcare provider will assess potential drug interactions before prescribing Evusheld.
• Pregnancy and breastfeeding: The safety of Evusheld during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Evusheld with your healthcare provider.
• Storage and handling: Store Evusheld vials and supplies according to the manufacturer’s instructions. Keep the medication refrigerated and protect it from light. Follow proper procedures for disposal of used needles and syringes to prevent accidental needle sticks.
• Monitoring: Your healthcare provider may monitor you for any signs of adverse reactions or complications while using Evusheld. Report any unusual symptoms or side effects to your healthcare provider promptly.

It’s crucial to follow your healthcare provider’s instructions and recommendations for using Evusheld and to communicate openly about any concerns or questions you may have.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are currently no specific dietary restrictions associated with Evusheld. However, maintaining a healthy and balanced diet can support overall health and immune function, which may be beneficial when using Evusheld.

What should I do if I forget a dose?

If you forget a dose of Evusheld, contact your healthcare provider or pharmacist for guidance. They can provide instructions on whether to administer the missed dose as soon as possible or to wait until the next scheduled dose. It’s essential to follow their recommendations to ensure the effectiveness of the medication. Avoid doubling the dose to make up for a missed one unless instructed to do so by your healthcare provider.

What side effects can this medication cause?

As with any medication, Evusheld (tixagevimab-cilgavimab) can cause side effects, although not everyone experiences them. Common side effects of Evusheld may include:

• Injection site reactions: Pain, redness, swelling, or itching at the injection site are common reactions. These usually resolve on their own within a few days.
• Allergic reactions: Some individuals may experience allergic reactions to Evusheld, which can range from mild to severe. Symptoms may include rash, itching, difficulty breathing, swelling of the face, lips, tongue, or throat. Seek medical attention immediately if you experience signs of an allergic reaction.
• Nausea and vomiting: Some people may experience gastrointestinal symptoms such as nausea or vomiting after receiving Evusheld.
• Fatigue: Feeling tired or fatigued may occur as a side effect of Evusheld.
• Headache: Headaches are another possible side effect of Evusheld.
• Fever: Fever may occur after receiving Evusheld, but it is usually mild and temporary.
• Muscle or joint pain: Some individuals may experience muscle or joint pain as a side effect of Evusheld.

It’s essential to report any side effects you experience to your healthcare provider, especially if they are persistent, severe, or concerning. Your healthcare provider can provide guidance on managing side effects and may adjust your treatment if necessary. Additionally, if you experience any unexpected or serious side effects, seek medical attention promptly.

What should I know about storage and disposal of this medication?

Storage and disposal of Evusheld:

• Storage: Store Evusheld vials in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect Evusheld from light. Keep the medication in its original carton until ready to use to protect it from light. Do not shake Evusheld. If Evusheld is accidentally frozen, do not use it, and contact your healthcare provider or pharmacist for guidance.
• Disposal: Safely dispose of used needles, syringes, and vials in a puncture-resistant container. Follow local regulations for disposal of medical waste. Do not reuse needles or syringes. If you have any questions about proper disposal, consult your healthcare provider or pharmacist.

In case of emergency/overdose

• Seek medical attention: If you suspect an overdose or experience severe adverse reactions after receiving Evusheld, seek immediate medical attention. Call emergency services or go to the nearest emergency room.
• Symptom management: If you experience symptoms of an allergic reaction or overdose, such as difficulty breathing, swelling of the face, lips, tongue, or throat, or severe injection site reactions, seek medical help immediately. Do not attempt to manage severe symptoms on your own.

What other information should I know?

• Follow-up appointments: Keep all scheduled appointments with your healthcare provider for follow-up evaluations while receiving Evusheld. Your healthcare provider may monitor you for any signs of adverse reactions or complications and adjust your treatment as needed.
• Reporting side effects: Report any side effects or adverse reactions to your healthcare provider or pharmacist. This information helps healthcare professionals monitor the safety and effectiveness of medications.
• Medication information: Keep Evusheld and all medications out of reach of children and pets. Do not share Evusheld with others, even if they have similar symptoms or medical conditions.
• Medical history: Inform your healthcare provider of your complete medical history, including any allergies, medical conditions, or medications you are taking. This information helps your healthcare provider determine if Evusheld is suitable for you and if any adjustments to your treatment are necessary.

Always follow your healthcare provider’s instructions and recommendations for using Evusheld, and do not hesitate to ask questions if you have any concerns or uncertainties about your treatment.