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Evkeeza (Generic Evinacumab-dgnb Injection)

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Why is this medication prescribed?

Evkeeza (evinacumab) is prescribed to treat homozygous familial hypercholesterolemia (HoFH), a rare genetic condition that leads to extremely high levels of low-density lipoprotein cholesterol (LDL-C) in the blood. It’s used as an adjunct to other lipid-lowering treatments, such as statins or other cholesterol-lowering medications, in patients with HoFH who require additional lowering of LDL-C.

How should this medicine be used?

Evkeeza (evinacumab-dgnb) is typically administered as an injection under the skin (subcutaneous injection) by a healthcare professional. Here’s a general overview of how Evkeeza is used:

  • Dosage: The recommended dosage of Evkeeza is usually determined by your healthcare provider based on factors such as your age, weight, medical condition, and response to treatment.
  • Administration: Evkeeza is administered as a subcutaneous injection, usually in the abdomen or thigh. Your healthcare provider will demonstrate the proper technique for administering the injection.
  • Frequency: Evkeeza is typically given once every four weeks. Follow your healthcare provider’s instructions regarding the dosing schedule.
  • Preparation: Before administering the injection, the healthcare provider will prepare the Evkeeza injection according to the manufacturer’s instructions. This may involve reconstituting the medication if it is supplied as a powder for reconstitution.
  • Injection Site: Rotate the injection site with each dose to minimize the risk of injection site reactions. Avoid injecting into areas that are bruised, tender, red, or hard.
  • Monitoring: Your healthcare provider will monitor your response to Evkeeza treatment through regular check-ups, including blood tests to measure cholesterol levels.
  • Additional Instructions: Always follow your healthcare provider’s instructions carefully regarding the use of Evkeeza. Do not change the dosage or frequency of administration without consulting your healthcare provider.

It’s important to adhere to the prescribed dosage and schedule for Evkeeza to achieve the desired therapeutic effects. If you have any questions or concerns about how to use Evkeeza, don’t hesitate to discuss them with your healthcare provider or pharmacist.

Other uses for this medicine

Evkeeza (evinacumab) is primarily used for the treatment of homozygous familial hypercholesterolemia (HoFH), as it specifically targets and reduces low-density lipoprotein cholesterol (LDL-C) levels in these patients. It’s important to note that Evkeeza is not indicated for the treatment of other conditions besides HoFH.

What special precautions should I follow?

As for special precautions, here are some key points to consider when using Evkeeza:

  • Allergic reactions: If you have a known allergy to evinacumab or any other ingredients in Evkeeza, inform your healthcare provider before starting treatment. Allergic reactions may include rash, itching, swelling, or difficulty breathing.
  • Infections: Like with any medication that affects the immune system, there may be an increased risk of infections. Inform your healthcare provider if you develop signs of an infection, such as fever, chills, sore throat, or cough.
  • Pregnancy and breastfeeding: The safety of Evkeeza during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Evkeeza with your healthcare provider before starting treatment.
  • Interactions with other medications: Before starting Evkeeza, inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and supplements. Some medications may interact with Evkeeza and affect its effectiveness or increase the risk of side effects.
  • Injection site reactions: Injection site reactions, such as redness, swelling, or pain at the injection site, may occur with the use of Evkeeza. If you experience persistent or severe injection site reactions, contact your healthcare provider.
  • Monitoring: Your healthcare provider may monitor your cholesterol levels and liver function regularly while you are receiving Evkeeza treatment.
  • Storage: Store Evkeeza prefilled syringes in the refrigerator between 36°F to 46°F (2°C to 8°C). Do not freeze Evkeeza. Keep it in its original carton to protect it from light.

Always follow the specific instructions provided by your healthcare provider for the use of Evkeeza and adhere to any special precautions or recommendations they provide based on your individual medical condition and needs. If you have any questions or concerns about Evkeeza, don’t hesitate to discuss them with your healthcare provider.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with the use of Evkeeza. However, maintaining a healthy diet low in saturated fats and cholesterol is generally recommended for individuals with hypercholesterolemia.

What should I do if I forget a dose?

If you forget to take a dose of Evkeeza, contact your healthcare provider for guidance. They may advise you on whether to take the missed dose as soon as you remember or to wait until your next scheduled dose. It’s essential to follow their instructions carefully to maintain consistent treatment.

What side effects can this medication cause?

Evkeeza (evinacumab) is a medication used to treat familial hypercholesterolemia, a genetic condition that causes high levels of cholesterol in the blood. Like any medication, Evkeeza can cause side effects, although not everyone will experience them. Some potential side effects of Evkeeza may include:

  • Injection site reactions: Pain, redness, swelling, or itching at the injection site.
  • Allergic reactions: Rarely, some people may experience allergic reactions such as rash, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat.
  • Flu-like symptoms: Headache, fatigue, fever, chills, or muscle aches.
  • Gastrointestinal symptoms: Nausea, vomiting, diarrhea, or abdominal pain.
  • Increased risk of infections: Evkeeza may lower the body’s ability to fight infections.

It’s essential to discuss any concerns or potential side effects with your healthcare provider before starting treatment with Evkeeza. They can provide personalized advice and monitor you for any adverse reactions while on the medication.

What should I know about storage and disposal of this medication?

When it comes to the storage and disposal of Evkeeza:

  • Storage:
    • Store Evkeeza in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C).
    • Do not freeze Evkeeza.
    • Keep Evkeeza in the original carton to protect it from light.
  • Disposal:
    • Dispose of any unused or expired Evkeeza properly.
    • Follow any specific disposal instructions provided by your healthcare provider or pharmacist.
    • Do not dispose of Evkeeza in household trash unless instructed to do so.

In case of emergency/overdose

  • In case of an overdose or emergency, contact your healthcare provider, poison control center, or seek emergency medical attention immediately.
  • Be prepared to provide information about the medication taken, including the name (Evkeeza), dosage, and time it was taken.

What other information should I know?

  • Always follow your healthcare provider’s instructions regarding the dosage and administration of Evkeeza.
  • Inform your healthcare provider about all other medications, supplements, and medical conditions you have before starting Evkeeza.
  • Attend all scheduled appointments with your healthcare provider for monitoring and evaluation of your condition while taking Evkeeza.
  • Report any adverse reactions or side effects experienced while taking Evkeeza to your healthcare provider promptly.
  • Do not change the dosage or stop taking Evkeeza without consulting your healthcare provider first.

Remember, this information is a general guideline, and specific instructions may vary depending on your individual circumstances and the recommendations of your healthcare provider. Always consult with your healthcare provider or pharmacist for personalized advice regarding the storage, disposal, and handling of Evkeeza.

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