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Ethacrynic Acid

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Why is this medication prescribed?

Adults and children with edoema (extra fluid retained in body tissues) brought on by conditions including cancer, heart illness, kidney disease, or liver disease are treated with ethacrynic acid. Ethacrynic acid is a member of the diuretic (often known as “water pills”) drug class. It functions by causing the kidneys to excrete salt and water from the body through the urine.

How should this medicine be used?

Ethacrynic acid is available as an oral tablet. Depending on your doctor’s instructions, it is typically given once or twice day with food or after meals. Ethacrynic acid should be taken every day at roughly the same time(s). Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Ethacrynic acid should only be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Other uses for this medicine

Ethacrynic acid is also used to treat diabetes insipidus of a specific type that does not respond to conventional medications, as well as excessive blood pressure. Discuss the potential dangers of using this medication for your illness with your doctor.

Other prescriptions for this drug are possible. For more information, consult your physician or chemist.

What special precautions should I follow?

Before taking ethacrynic acid,

  • If you have an allergy to ethacrynic acid, any other medications, or any of the chemicals in ethacrynic acid tablets, let your doctor and chemist know right away. For a list of the ingredients, ask your doctor or chemist.
  • Inform your doctor and chemist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Any of the following should be mentioned: Amikacin and gentamicin (Garamycin), two aminoglycoside antibiotics; warfarin (Coumadin, Jantoven); anticoagulants (sometimes known as “blood thinners”); corticosteroids like dexamethasone and hydrocortisone (Cortef), as well as cephalosporin antibiotics like cefaclor, cefadroxil, and cephalexin (Keflex), digoxin (Lanoxin), lithium (Lithobid), methylprednisolone (Medrol), prednisolone (Prelone), or prednisone (Rayos); as well as non-steroidal anti-inflammatory drugs like naproxen (Aleve) and ibuprofen (Advil, Motrin). Your physician might need to adjust the dosage of your drugs or keep a closer eye on you for adverse effects.
  • In case you have kidney illness, let your doctor know. Your physician could advise against taking ethacrynic acid.
  • If you have diabetes, gout, or liver disease, let your doctor know.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking ethacrynic acid.
  • If you are 65 years of age or older, discuss the advantages and disadvantages of taking ethacrynic acid with your doctor. Ethacrynic acid is often not recommended for usage by older adults since it is less safe than other drugs that can be used to treat the same disease.

What special dietary instructions should I follow?

Observe your doctor’s recommendations. Exercise on a regular basis, a low-sodium or low-salt diet, potassium supplements, and consuming more potassium-rich foods (such as bananas, prunes, raisins, and orange juice) are a few examples of preventative measures.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If your next dose is approaching, skip the missed one and carry on with your regular dosing regimen. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Side effects from ethacrynic acid are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Frequent urination, which should last no more than a few weeks
  • Nausea
  • Vomiting
  • Reduced appetite
  • Abdominal pain
  • Having trouble swallowing
  • Reduced appetite
  • Thirst
  • Muscular pain
  • Weakness
  • Headache
  • Diarrhea

Some adverse effects can be very harmful. Call your doctor right away and stop taking ethacrynic acid if you suffer any of the following symptoms:

  • Severe diarrhoea with water
  • Decline in hearing
  • Confusion
  • Decline in balance
  • Having ringing or full ears
  • Eyes or skin that have a yellow tint
  • Uncommon bruising or bleeding
  • Rash
  • Hives
  • Breathing or swallowing challenges

Other negative consequences of ethacrynic acid are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online at or by phone at 1-800-332-1088 if you suffer a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the ideal approach to get rid of your medicines. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling department in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. During treatment, your doctor may keep an eye on your weight and blood pressure while also requesting blood tests to determine how your body is reacting to ethacrynic acid.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Edecrin®
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