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Why is this medication prescribed?

Prostate cancer that has progressed or spread to other parts of the body is treated with estramustine. Estramustine belongs to the group of drugs known as antimicrotubule agents. It functions by preventing the development and spread of cancer cells.

How should this medicine be used?

Estramustine is available as a pill to swallow. Three to four times a day, at least an hour before or two hours after meals, it is typically taken with water. Take estramustine away from milk, milk products, and meals that are high in calcium. Take estramustine every day at roughly the same time. Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Take estramustine as prescribed by your doctor. Never take it in larger or less amounts or more frequently than directed by your doctor.

While it may slow the growth of your cancer, estramustine does not treat it. Before your doctor can determine whether this drug is effective for your illness, it could take up to 3 months. As you receive estramustine treatment, be sure to discuss your feelings with your doctor. Even if you feel well, keep taking estramustine. Without consulting your doctor, do not stop taking estramustine.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking estramustine,

  • If you have any drug allergies, including those to estramustine, estradiol, nitrogen mustard, or any other drugs, tell your doctor right away.
  • Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use.
  • If you use calcium supplements or antacids like Alka-Mints, Tums, or Titralac that include calcium, you should take them at least 2 hours before or 2 hours after estramustine.
  • A blood clot, diabetes, high blood pressure, a stroke, congestive heart failure, migraines, seizures, any disorders that influence the balance of calcium and phosphorous in your body, such as parathyroid dysfunction, liver or kidney illness, congestive heart failure, or any of these, should be disclosed to your doctor.
  • You should be aware that only guys should use estramustine. Estramustine might harm a foetus. If there’s a chance your spouse could get pregnant while you’re on estramustine, you should use reliable birth control. Estramustine shouldn’t be taken by pregnant or potentially pregnant women. Call your doctor right away if you take estramustine while pregnant.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

There may be negative effects from estramustine. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Diarrhea
  • Breast enlargement and sensitivity
  • Leg twitches
  • Tiredness
  • Having trouble falling or staying asleep
  • Inability to obtain or sustain an erection, or impotence

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or symptoms:

  • Edoema of the hands, feet, ankles, lower legs, cheeks, neck, tongue, lips, and eyes
  • Hoarseness
  • Breathing or swallowing challenges
  • Breathing difficulty
  • Chest ache
  • Faintness or dizziness
  • Speech issues
  • An abrupt, bad headache
  • Abrupt visual loss, either partial or whole
  • An arm or a leg that is weak or numb
  • Discomfort, erythema, or swelling in the arm or leg

Other negative effects of estramustine are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online at or by phone at 1-800-332-1088 if you suffer a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Capsules of estramustine should be kept cold.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the ideal approach to get rid of your medicines. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling department in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s response to estramustine, your doctor will request specific lab tests.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Emcyt®
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