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Erwinaze (Generic Asparaginase Erwinia chrysanthemi Injection)

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Why is this medication prescribed?

Acute lymphocytic leukaemia (ALL), a kind of white blood cell malignancy, is treated with asparaginase erwinia chrysanthemi in combination with other chemotherapeutic drugs. It is prescribed to individuals who have experienced adverse responses to asparaginase (Elspar) or pegaspargase (Oncaspar), two drugs that are identical to asparaginase erwinia chrysanthemi. An enzyme called asparaginase erwinia chrysanthemi prevents the natural compounds required for the growth of cancer cells. It stops the growth of cancer cells or kills them.

How should this medicine be used?

A doctor or nurse in a hospital will mix powdered asparaginase erwinia chrysanthemi with fluid before injecting it into a muscle. Typically, it is administered three times each week.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking asparaginase Erwinia chrysanthemi,

  • If you have any allergies, including to asparaginase erwinia chrysanthemi, any other medications, or any of the chemicals in asparaginase erwinia chrysanthemi powder, notify your doctor and chemist very away. Request a list of the ingredients from your chemist.
  • Inform your doctor and chemist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use.
  • Inform your physician if you are currently experiencing or have previously experienced pancreatitis (pancreatic enlargement), blood clots, or serious bleeding, especially if these occurred while you were taking asparaginase (Elspar) or pegaspargase (Oncaspar). You won’t likely get asparaginase Erwinia chrysanthemi from your doctor.
  • If you have diabetes now or formerly had it, let your doctor know.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor right away if you fall pregnant while taking asparaginase erwinia chrysanthemi.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Call your doctor as soon as possible if you forget to show up for your asparaginase erwinia chrysanthemi appointment.

What side effects can this medication cause?

Erwinia chrysanthemi’s asparaginase may have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Fever

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Hives
  • Rash
  • Itching
  • Breathing or swallowing challenges
  • Chronic stomach ache that occasionally radiates to the back
  • Severe thirst
  • Excessive urination
  • Severe hunger
  • Weakness
  • Fuzzy vision
  • Headache
  • Legs or arms swelling
  • Breathing difficulty
  • Chest ache
  • Uncommon bleeding
  • Eyes or skin that have a yellow tint
  • Stomach ache in the top right corner
  • Urine with a dark colour
  • Reduced appetite
  • Not enough energy
  • Seizure

Other adverse effects from Asparaginase Erwinia Chrysanthemi may occur. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What other information should I know?

Keep all of your appointments with your physician and the lab. In order to monitor your body’s reaction to asparaginase erwinia chrysanthemi, your doctor will request specific lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Erwinaze®
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