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Erleada (Generic Apalutamide)

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Why is this medication prescribed?

Erleada (apalutamide) is a medication prescribed for the treatment of prostate cancer. Specifically, it is indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer (nmCRPC).

Non-metastatic castration-resistant prostate cancer is a form of prostate cancer that does not respond to hormone therapy (castration) and does not show evidence of spreading to other parts of the body (metastasis) on imaging tests like bone scans or CT scans.

Erleada works by inhibiting the activity of androgen receptors, which are proteins found on the surface of prostate cancer cells. By blocking these receptors, Erleada helps to slow down the growth and spread of prostate cancer cells.

How should this medicine be used?

Erleada (apalutamide) is typically taken orally, in the form of tablets. Here’s a general guideline on how Erleada should be used:

  • Dosage: The usual recommended dose of Erleada for non-metastatic castration-resistant prostate cancer (nmCRPC) is 240 mg once daily. This typically involves taking four 60 mg tablets all at once.
  • Administration: Erleada tablets can be taken with or without food. You can swallow the tablets whole with water. It’s important not to crush, chew, or break the tablets.
  • Timing: Take Erleada at approximately the same time each day to maintain a consistent level of the medication in your body.
  • Follow Doctor’s Instructions: Always follow the dosage and administration instructions provided by your doctor or healthcare provider. They may adjust the dosage or provide specific instructions based on your individual circumstances.
  • Duration of Treatment: Continue taking Erleada for as long as your doctor prescribes it, even if you start feeling better. Do not stop taking the medication unless directed by your doctor.
  • Monitoring: Your doctor will monitor your progress and may perform regular blood tests to check for any potential side effects or changes in your condition.
  • Side Effects: Be aware of potential side effects of Erleada and report any unusual symptoms to your doctor promptly. Common side effects may include fatigue, high blood pressure, rash, diarrhea, nausea, weight loss, decreased appetite, and joint pain.
  • Storage: Store Erleada tablets at room temperature away from moisture and heat. Keep the medication out of reach of children and pets.

Always consult your doctor or healthcare provider if you have any questions or concerns about how to use Erleada properly. They can provide personalized guidance based on your medical history and treatment needs.

Other uses for this medicine

Other uses for Erleada may be explored, but it’s primarily indicated for the treatment of prostate cancer. It’s essential to consult with a healthcare professional for guidance on any off-label uses or alternative treatments.

What special precautions should I follow?

Regarding special precautions for Erleada, here are some important points to consider:

  • Pregnancy and breastfeeding: Erleada can cause fetal harm if taken during pregnancy. It is not recommended for use in women, especially pregnant or breastfeeding women, due to potential risks to the fetus or infant. Effective contraception should be used by men taking Erleada if their sexual partner is pregnant or could become pregnant.
  • Liver function: Erleada may affect liver function, so your doctor may monitor your liver enzymes regularly while you are taking the medication. Inform your doctor if you have a history of liver disease or experience symptoms such as jaundice (yellowing of the skin or eyes), dark urine, or abdominal pain.
  • Interactions with other medications: Before starting Erleada, inform your doctor about all the medications, supplements, and herbal products you are currently taking. Some medications may interact with Erleada, potentially affecting its effectiveness or increasing the risk of side effects.
  • Allergic reactions: If you have a known allergy to apalutamide or any of the inactive ingredients in Erleada, inform your doctor before starting treatment.
  • Medical conditions: Discuss any other medical conditions you have with your doctor before starting Erleada. Certain conditions may require special monitoring or adjustments to your treatment plan.
  • Side effects: Be aware of potential side effects of Erleada and report any unusual symptoms to your doctor promptly. Common side effects include fatigue, high blood pressure, rash, diarrhea, nausea, weight loss, decreased appetite, and joint pain.

Always follow your doctor’s instructions and guidance while taking Erleada, and do not hesitate to ask questions or seek clarification about any concerns you may have.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with taking Erleada. However, maintaining a healthy and balanced diet as recommended by your healthcare provider is generally advisable for overall well-being.

What should I do if I forget a dose?

If you forget to take a dose of Erleada, take it as soon as you remember on the same day. If it’s almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at once to make up for a missed dose.

What side effects can this medication cause?

Erleada (apalutamide) can cause various side effects, some of which may require medical attention. Common side effects experienced by patients taking Erleada include:

  • Fatigue: Feeling tired or lacking energy is a common side effect of Erleada.
  • High Blood Pressure (Hypertension): Some individuals may experience an increase in blood pressure while taking Erleada. Regular monitoring of blood pressure is typically recommended during treatment.
  • Rash: Skin rash or irritation, which may manifest as redness, itching, or other skin changes, can occur.
  • Diarrhea: Some people may experience diarrhea while taking Erleada.
  • Nausea: Feeling nauseous or experiencing an upset stomach is another possible side effect.
  • Weight Loss: Some patients may experience weight loss while on Erleada treatment.
  • Decreased Appetite: A reduction in appetite may occur in some individuals.
  • Joint Pain: Pain or discomfort in the joints can be a side effect of Erleada.
  • Fractures: There is an increased risk of fractures associated with Erleada treatment.
  • Hot Flashes: Some individuals may experience hot flashes or flushing as a side effect.
  • Headache: Headaches can occur in some patients taking Erleada.
  • Hypothyroidism: Some individuals may experience a decrease in thyroid function while taking Erleada.

It’s important to note that not all individuals will experience these side effects, and some may experience side effects not listed here. Additionally, the severity of side effects can vary from person to person.

If you experience any concerning or bothersome side effects while taking Erleada, it’s important to inform your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment plan if necessary.

What should I know about storage and disposal of this medication?

Storage and disposal of Erleada:


  • Store Erleada tablets at room temperature, away from moisture and heat.
  • Keep the medication in its original container or packaging.
  • Store Erleada out of reach of children and pets.


  • Dispose of unused or expired Erleada tablets properly according to local regulations or guidelines.
  • Do not flush medications down the toilet or pour them down the drain unless instructed to do so.
  • Consult your pharmacist or healthcare provider for information on how to properly dispose of Erleada.

In case of emergency/overdose

  • In case of an overdose or emergency, such as accidentally taking too much Erleada, seek medical attention or contact a poison control center immediately.
  • Symptoms of an overdose may include severe nausea, vomiting, dizziness, or difficulty breathing.
  • It’s essential to have the container or packaging of Erleada with you to provide information to healthcare professionals.

What other information should I know?

  • Keep all appointments with your doctor for monitoring and follow-up while taking Erleada.
  • Inform all healthcare providers involved in your care that you are taking Erleada, including dentists and pharmacists.
  • Do not share Erleada with others, even if they have the same condition, as it is prescribed based on individual circumstances.
  • Follow your doctor’s instructions carefully regarding dosage, administration, and any other recommendations related to your treatment with Erleada.
  • If you have any questions or concerns about Erleada, its usage, side effects, or any other aspect of your treatment, do not hesitate to discuss them with your healthcare provider.

It’s crucial to adhere to all instructions provided by your healthcare provider and pharmacist regarding the storage, disposal, and usage of Erleada to ensure safe and effective treatment.

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