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Why is this medication prescribed?

Eplerenone is a medication prescribed primarily for the management of high blood pressure (hypertension) and heart failure. It belongs to a class of drugs called aldosterone receptor antagonists. Aldosterone is a hormone produced by the adrenal glands that regulates sodium and water balance in the body, thus affecting blood pressure and fluid retention. Eplerenone works by blocking the effects of aldosterone, leading to decreased sodium retention and water retention, which in turn helps to lower blood pressure and reduce the workload on the heart.

In addition to treating hypertension and heart failure, eplerenone may also be prescribed for conditions such as chronic kidney disease and certain types of heart conditions following a heart attack.

How should this medicine be used?

Eplerenone is typically taken orally in the form of tablets. Here are general guidelines for its use:

  • Dosage: The dosage of eplerenone varies depending on the individual’s medical condition, response to treatment, and other factors. It’s crucial to follow the dosage instructions provided by the prescribing healthcare provider.
  • Administration: Eplerenone tablets are usually taken by mouth. They can be taken with or without food, but it’s essential to take them consistently as directed by the healthcare provider.
  • Timing: Eplerenone is often taken once daily. However, the specific timing may vary depending on individual circumstances and healthcare provider instructions. It’s important to establish a routine for taking the medication and to adhere to it consistently.
  • Swallowing: The tablets should be swallowed whole with a glass of water. They should not be crushed, chewed, or broken apart unless specifically instructed to do so by a healthcare provider.
  • Monitoring: While taking eplerenone, it’s essential to monitor blood pressure and other relevant health parameters regularly as advised by the healthcare provider. This helps ensure that the medication is effectively managing the condition and allows for adjustments in dosage or treatment plan if necessary.
  • Duration: Eplerenone is usually prescribed for long-term management of conditions such as hypertension and heart failure. It’s important to continue taking the medication even if symptoms improve unless otherwise instructed by a healthcare provider.
  • Do not stop abruptly: It’s crucial not to stop taking eplerenone suddenly without consulting a healthcare professional. Abruptly discontinuing the medication can lead to a rebound increase in blood pressure or worsening of heart failure symptoms. If there’s a need to discontinue or change the medication, healthcare providers will typically provide guidance on how to do so safely.

As always, it’s important to follow the specific instructions provided by the prescribing healthcare provider and to ask any questions or raise any concerns about the medication’s use.

Other uses for this medicine

Some other potential uses for eplerenone include:

  • Heart conditions following a heart attack: Eplerenone may be used to reduce the risk of cardiovascular events and improve outcomes in patients who have experienced a heart attack.
  • Chronic kidney disease: Eplerenone may be used in the management of chronic kidney disease, particularly in patients with proteinuria (excess protein in the urine) and hypertension.
  • Left ventricular dysfunction: Eplerenone may be used to improve outcomes in patients with left ventricular dysfunction following myocardial infarction (heart attack) or heart failure.

What special precautions should I follow?

Special precautions should be observed when taking eplerenone, and it’s essential to follow healthcare provider instructions closely. Here are some important precautions:

  • Pregnancy and breastfeeding: Eplerenone may harm an unborn baby, so it’s important to inform the healthcare provider if you are pregnant or planning to become pregnant. Additionally, it’s not recommended to breastfeed while taking eplerenone.
  • Kidney function: Eplerenone is primarily eliminated through the kidneys, so individuals with impaired kidney function may require dosage adjustments or closer monitoring while taking the medication.
  • Potassium levels: Eplerenone can cause hyperkalemia (high potassium levels), especially in individuals with kidney impairment or those taking other medications that can increase potassium levels. Regular monitoring of potassium levels is typically recommended, and healthcare providers may adjust the dosage or recommend dietary changes if hyperkalemia occurs.
  • Liver function: Eplerenone is metabolized in the liver, so individuals with liver impairment may require dosage adjustments or closer monitoring.
  • Interactions with other medications: Eplerenone may interact with other medications, including potassium supplements, potassium-sparing diuretics, ACE inhibitors, and angiotensin II receptor blockers. It’s important to inform the healthcare provider about all medications, supplements, and herbal products being taken to avoid potential interactions.
  • Dehydration and electrolyte imbalance: Eplerenone can increase the risk of dehydration and electrolyte imbalance, particularly in individuals who are elderly or have other medical conditions. It’s important to stay well-hydrated and to report any signs of dehydration or electrolyte imbalance, such as dizziness, weakness, or irregular heartbeat, to the healthcare provider.
  • Allergic reactions: Individuals with a known allergy to eplerenone or any of its ingredients should not take the medication. Allergic reactions to eplerenone can be serious and require immediate medical attention.

Always consult with a healthcare professional for personalized advice and guidance regarding the use of eplerenone and any potential precautions or interactions based on individual health status and medical history.

What special dietary instructions should I follow?

  • Potassium-rich foods: Since eplerenone can increase potassium levels in the blood, it may be advisable to avoid or limit consumption of potassium-rich foods, such as bananas, oranges, potatoes, tomatoes, spinach, and avocados. However, it’s important to discuss dietary changes with your healthcare provider, as they can provide personalized recommendations based on your individual health status and medication regimen.

What should I do if I forget a dose?

  • Take it as soon as you remember: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
  • Do not double up: Do not take a double dose to make up for a missed one. Taking extra medication can increase the risk of side effects and complications.
  • Follow instructions: If you have any questions or concerns about missed doses, contact your healthcare provider or pharmacist for guidance. They can provide specific advice based on your individual circumstances.

What side effects can this medication cause?

Eplerenone, like any medication, can cause side effects, although not everyone experiences them. Common side effects of eplerenone may include:

  • Hyperkalemia: Elevated levels of potassium in the blood. This is a potentially serious side effect and may cause symptoms such as weakness, fatigue, numbness, tingling sensations, irregular heartbeat, or muscle cramps.
  • Dizziness: Feeling lightheaded or dizzy, especially when standing up from a sitting or lying position.
  • Headache: Mild to moderate headaches may occur in some individuals.
  • Nausea: Feeling sick to your stomach or experiencing stomach discomfort.
  • Diarrhea: Loose or watery stools that may occur as a side effect of eplerenone.
  • Fatigue: Feeling tired or lacking energy may be experienced by some individuals.
  • Cough: A persistent cough may occur in some people taking eplerenone.
  • Increased urination: Some individuals may notice an increase in the frequency of urination while taking eplerenone.
  • Gynecomastia: Swelling of breast tissue in men may occur as a rare side effect of eplerenone.
  • Allergic reactions: Although rare, some people may experience allergic reactions to eplerenone, which can manifest as rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing.

It’s important to report any unusual or bothersome side effects to your healthcare provider. Additionally, if you experience any signs of a serious allergic reaction, seek immediate medical attention.

This list does not include all possible side effects of eplerenone. If you have concerns about potential side effects or notice any symptoms while taking eplerenone, talk to your healthcare provider for further evaluation and guidance. They can provide personalized advice based on your individual health status and medication regimen.

What should I know about storage and disposal of this medication?

Storage and Disposal of eplerenone:


  • Store eplerenone tablets at room temperature away from light and moisture.
  • Keep the medication out of reach of children and pets.
  • Do not store eplerenone in the bathroom or near the kitchen sink, where it may be exposed to moisture.


  • Dispose of unused or expired eplerenone tablets properly according to local regulations or guidelines.
  • Do not flush medications down the toilet unless instructed to do so. Instead, dispose of them in a safe and environmentally responsible manner, such as through a medication take-back program or by using a drug disposal pouch.
  • If no take-back programs are available, mix the medication with an undesirable substance (such as coffee grounds or cat litter) in a sealed plastic bag and throw it in the trash.

In case of emergency/overdose

  • In case of an overdose of eplerenone, seek emergency medical attention or contact a poison control center immediately.
  • Symptoms of overdose may include severe dizziness, fainting, irregular heartbeat, confusion, or muscle weakness.
  • It’s essential to provide healthcare providers with as much information as possible about the medication taken and the amount ingested.

What other information should I know?

  • Inform all healthcare providers involved in your care about your use of eplerenone, including dentists, pharmacists, and specialists.
  • Keep a list of all medications you are taking, including prescription and over-the-counter drugs, as well as any herbal supplements or vitamins.
  • Be cautious when driving or operating machinery, as eplerenone may cause dizziness or lightheadedness, especially at the beginning of treatment.
  • Attend all scheduled appointments with your healthcare provider for monitoring and evaluation of your condition.
  • Do not share eplerenone with others, even if they have similar symptoms or conditions.
  • Follow all instructions provided by your healthcare provider regarding dosing, dietary restrictions, and other recommendations for managing your condition effectively.

If you have any additional questions or concerns about eplerenone, its storage, usage, or potential side effects, don’t hesitate to consult your healthcare provider or pharmacist for further guidance.

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