Eplerenone is used to treat high blood pressure either alone or in combination with other drugs. Eplerenone is a member of the mineralocorticoid receptor antagonists drug class. It functions by preventing the body’s endogenous hormone aldosterone from raising blood pressure.

High blood pressure is a common illness that, if left untreated, can harm the kidneys, brain, heart, blood vessels, and other organs. Heart disease, a heart attack, heart failure, a stroke, renal failure, eyesight loss, and other issues may result from damage to these organs. Making lifestyle modifications will help you control your blood pressure in addition to taking medication. These adjustments include quitting smoking, drinking alcohol in moderation, eating a diet low in fat and salt, keeping a healthy weight, and exercising for at least 30 minutes most days.

Eplerenone is available as a tablet for oral use. With or without food, it is often taken once or twice day. Take eplerenone every day at roughly the same time(s) to help you remember to take it. Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Follow the prescription for eplerenone exactly. Never take it in larger or less amounts or more frequently than directed by your doctor.

Your doctor might prescribe a low dose of eplerenone at first and then raise it after 4 weeks.

Although it doesn’t treat high blood pressure, eplerenone manages it. The full effects of eplerenone might not be felt for up to 4 weeks. Even if you feel good, keep taking eplerenone. Without consulting your doctor, do not discontinue taking eplerenone.

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

Before taking eplerenone,

• If you have any allergies, especially to any of the chemicals in eplerenone tablets, tell your doctor and chemist right away. For a list of the ingredients, ask your chemist.
• If you are taking potassium supplements, spironolactone (Aldactone), spironolactone and hydrochlorothiazide (Aldactazide), triamterene (Dyrenium), or triamterene and hydrochlorothiazide (Dyazide, Maxzide), you should not take eplerenone.
• Inform your physician and chemist of all prescription and non-prescription drugs, vitamins, and dietary supplements you are taking. Any of the following should be mentioned: drugs that block the action of the angiotensin-converting enzyme (ACE), such as benazepril (Lotensin, in Lotrel), captopril (Capoten), enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Prinzide, in Zestoretic), and quinapril (Accupril, in Accuretic, in Quinaretic); angiotensin II receptor antagonists include azilsartan (Edarbi, Edarbyclor), candesartan (Atacand, Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, Avalide), losartan (Cozaar, Hyzaar), olmesartan (Benicar, Azor, Benicar HCT), aspirin and other nonsteroidal anti-inflammatory medicines (NSAIDs), including ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (Diovan, in Diovan HCT, in Exforge; erythromycin (E.E.S., E-Mycin, Erythrocin); fluconazole (Diflucan); fluoxetine (Prozac, Sarafem, Selfemra); danazol; delavirdine (Rescriptor); diltiazem (Cardizem, Dilacor, Tiazac, among others); isoniazid (Laniazid, in Rifamate, Rifater); lithium (Lithobid); metronidazole (Flagyl); nefazodone; fluvoxamine (Luvox); HIV protease inhibitors such as indinavir (Crixivan), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); zafirlukast (Accolate) and verapamil (Calan, Covera, and Verelan in Tarka). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
• Inform your doctor if you have diabetes, gout, liver disease, excessive blood potassium levels, or any other medical conditions.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while taking eplerenone.

If you plan to consume grapefruit juice while taking this medication, consult your doctor.

While taking eplerenone, avoid using potassium-containing salt alternatives. If your doctor advises a low-salt or low-sodium diet, strictly follow the instructions.

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

Eplerenone could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Headache
• Dizziness
• Diarrhea
• Abdominal pain
• Cough
• Extreme fatigue
• Flu-like signs
• Breast tenderness or enlargement
• Unexpected vaginal bleeding

Some adverse effects can be very harmful. Even though the following signs are unusual, you should call your doctor right once if you notice any of them:

• Chest ache
• Legs and arms start to tingle
• Decline in muscular tone
• Leg heaviness or weakness
• Confusion
• Not enough energy
• Grey, chilly skin
• Unsteady heartbeat

negative effects of eplerenone could occur. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088 if you have a serious side event.

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilizing a medicine take-back program is the easiest approach to get rid of your medication. To find out about take-back programs in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.http://www.upandaway.org

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

• Fainting
• Dizziness
• Uneasy stomach
• Legs and arms start to tingle
• Decline in muscular tone
• Leg heaviness or weakness
• Confusion
• Not enough energy
• Grey, chilly skin
• Slow or irregular heartbeat

Keep all of your appointments with your physician and the lab. Regular blood pressure checks and specific lab tests will be prescribed by your doctor to monitor your body’s reaction to eplerenone.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.