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Entresto (Generic Valsartan and Sacubitril)

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If you are pregnant or want to become pregnant, let your doctor know. If you are pregnant, avoid taking valsartan and sacubitril together. If you become pregnant while using valsartan with sacubitril, notify your doctor right once and stop taking the medications. When taken in the latter six months of pregnancy, the combination of valsartan and sacubitril may result in the fetus’s death or severe damage.

Why is this medication prescribed?

Adults with specific forms of heart failure can reduce their risk of death and hospitalization by taking valsartan and sacubitril along with other drugs. Additionally, certain forms of congestive heart failure in children 1 year of age and older are treated with the combination of valsartan and sacubitril. Angiotensin II receptor antagonists, which include valsartan, are a group of medicines. It functions by preventing the tightening of blood arteries caused by several natural chemicals, allowing blood to flow more freely and the heart to pump more effectively. The drug sacubitril belongs to the group of drugs known as neprilysin inhibitors. It helps regulate blood volume.

How should this medicine be used?

The oral tablet containing valsartan and sacubitril is available. Typically, it is taken twice daily, with or without food. Take the valsartan and sacubitril combination at roughly the same times each day to help you remember to take it. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Exactly as prescribed, take sacubitril and valsartan. Never take it in larger or less amounts or more frequently than directed by your doctor.

If you or your kid has difficulty swallowing the tablets, your pharmacist can make an oral suspension (liquid) of this medication. Before each administration, give the suspension container a good shake.

Your doctor might begin you on a low dose of sacubitril with valsartan and then gradually increase it.

Valsartan and sacubitril together manage heart failure but do not cure it. Even if you feel good, keep taking sacubitril and valsartan. Without first seeing your physician, do not discontinue taking sacubitril and valsartan.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking valsartan and sacubitril,

  • Inform your doctor and pharmacist if you have any of the following side effects from valsartan: swelling of the face, lips, tongue, or throat; wheezing; or difficulty breathing, losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), and benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, and lisinopril (in Prinzide, in Zestoretic) are examples of angiotensin-converting enzyme (ACE) inhibitors, ramipril (Altace), quinapril (Accupril, in Accuretic, in Quinaretic), moexipril (Univasc, in Uniretic), perindopril (Aceon, in Prestalia), or trandolapril (Mavik, in Tarka); sacubitril; any other drugs; or any of the components in valsartan and sacubitril pills. Request an ingredient list from your pharmacist.
  • If you take aliskiren (Tekturna, Tekturna HCT) and have diabetes (high blood sugar), let your doctor know. If you have diabetes and are also on aliskiren, your doctor generally won’t let you combine valsartan with sacubitril. As well as disclosing your use of ACE inhibitors including benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, and lisinopril (in Prinzide, in Zestoretic), uenapril (Accupril, in Accuretic, in Quinaretic), moexipril (Univasc, in Uniretic), perindopril (Aceon, in Prestalia), ramipril (Altace), trandolapril (Mavik, in Tarka), or if you have stopped taking an ACE inhibitor within the last 36 hours. If you also take an ACE-inhibitor, your doctor would probably advise against using valsartan and sacubitril.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter medications, vitamins, herbal items, nutritional supplements, and any drugs you are now taking or intend to take. ARBs such eprosartan (Teveten), candesartan (Atacand), and azilsartan (Edarbi, in Edarbyclor), among others, should be mentioned, olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), telmisartan (Micardis, in Micardis HCT, in Twynsta); aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) such ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and celecoxib (Celebrex), as well as selective COX-2 inhibitors; diuretics (often known as “water pills”), such as potassium-sparing diuretics like triamterene (Dyrenium, in Dyazide, in Maxzide), spironolactone (Aldactone), and amiloride (Midamor); among the drugs used to treat heart disease or high blood pressure include lithium (Lithobid), gemfibrozil (Lopid), and potassium supplements. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have or have ever had diabetes, renal, liver, or hereditary angioedema, an inherited disorder that produces episodes of swelling in the hands, feet, face, airway, or intestines.
  • If you are breastfeeding, let your doctor know. If you are on valsartan and sacubutril, you should not breastfeed.
  • You should be aware that valsartan plus sacubutril may result in lightheadedness, fainting, and dizziness if you stand up suddenly from a laying position. When taking valsartan and sacubitril for the first time, this is more typical. Slowly getting out of bed and letting your feet rest on the floor for a few minutes before standing up will help you prevent this issue.
  • You should be aware that a reduction in blood pressure might result from diarrhoea, vomiting, dehydration, and excessive perspiration, which can make you feel faint and dizzy. If you have any of these issues or if any emerge while you are receiving treatment, let your doctor know.

What special dietary instructions should I follow?

Use potassium-containing salt replacements only after consulting your doctor. Follow these instructions closely if your doctor advises a low-salt or low-sodium diet.

What should I do if I forget a dose?

As soon as you recall, take the missed dose. Skip the missed dose and carry on with your regular dosing plan, nevertheless, if it is almost time for the subsequent dose. Never take two doses at once to make up for missing ones.

What side effects can this medication cause?

Side effects are possible with sacubitril and valsartan. If any of these symptoms are severe or do not go away, consult your doctor:

  • Cough
  • Utter exhaustion

Some adverse effects may be severe. Call your doctor right away if you notice any of the following symptoms or any of those detailed in the SPECIAL PRECAUTIONS section:

  • Rash
  • Itching
  • Lip, tongue, face, or throat swelling
  • Having trouble breathing

Other negative effects could result with valsartan and sacubitril together. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. The tablets should be kept at room temperature, away from sources of extreme heat, and dry (not in the bathroom). Do not refrigerate the oral suspension container; instead, keep it at room temperature for up to 15 days.

All medications should be kept out of the sight and reach of children, as many of the containers (such as weekly pill containers and those for eye drops, lotions, patches, and inhalers) are not child-resistant and are simple for small children to open. Always lock safety caps and put the medication in a secure spot right away, up high and out of young children’s sight and reach, to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilizing a medicine take-back program is the easiest approach to get rid of your medication. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To determine how well your body is responding to valsartan with sacubitril, your doctor may request specific lab tests.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Entresto®
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