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Enfortumab vedotin-ejfv Injection

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Skin responses from fortumab vedotin-ejfv may be severe or even fatal. While you are taking the drug, your doctor will keep a close eye out for any skin responses. Call your doctor right away if you have any of the following symptoms: Blisters, peeling skin, painful sores, or ulcers on your skin, lips, nose, or mouth; a fever or flu-like symptoms; or swollen glands are all signs of an infection.

Keep all of your appointments with your physician and the lab. To determine how your body is reacting to enfortumab vedotin-ejfv, your doctor will prescribe a number of tests.

Discuss the dangers of obtaining an injection of enfortumab vedotin-ejfv with your doctor.

Why is this medication prescribed?

Enfortumab vedotin-ejfv injection is used to treat urothelial cancer (cancer of the lining of the bladder and other urinary tract), which has deteriorated after treatment with other chemotherapy drugs or if these chemotherapy drugs cannot be used for treatment, and has spread to nearby tissues or other parts of the body or cannot be removed surgically. The pharmaceutical enfortumab vedotin-ejfv injection belongs to the monoclonal antibody drug class. It functions by assisting your immune system in reducing or halting the spread of cancer cells.

How should this medicine be used?

A doctor or nurse will administer the intravenous (into a vein) injection of enfortumab vedotin-ejfv over the course of 30 minutes after mixing the powder with liquid. For as long as your doctor advises you to undergo treatment, it is typically injected on days 1, 8, and 15 of a 28-day cycle.

Depending on how you respond to the drug and any adverse effects you experience, your doctor may postpone or discontinue your enfortumab vedotin-ejfv injectable treatment or treat you with additional medications. Discuss your feelings regarding your treatment with your doctor.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving enfortumab vedotin-ejfv injection,

  • If you have an allergy to enfortumab vedotin-ejfv injection, any other medications, or any of the ingredients in enfortumab vedotin-ejfv injection, notify your doctor right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have or have had had liver illness, diabetes, high blood sugar, lung issues, or peripheral neuropathy (a kind of nerve injury that produces tingling, numbness, and discomfort in the hands and feet).
  • Inform your physician if you are expecting, intend to become pregnant, or intend to father a child. While receiving enfortumab vedotin-ejfv injection, neither you nor your partner should become pregnant. Before administering the enfortumab vedotin-ejfv injection, your doctor may do a pregnancy test to make sure you are not expecting. During treatment and for two months following your last dose, female patients should utilize birth control. If you’re a man, you should use birth control while receiving therapy and for four months following your last dose, together with your female partner. Discuss effective birth control options with your doctor. Call your doctor if you or your partner become pregnant while receiving an injection of enfortumab vedotin-ejfv. Injection of fortumab vedotin-ejfv may be harmful to the fetus.
  • Inform your doctor if you are nursing a baby. While receiving enfortumab vedotin-ejfv injection and for at least 3 weeks following your final dosage, you shouldn’t breastfeed.
  • You should be aware that this drug may reduce male fertility. Discuss the dangers of obtaining an injection of enfortumab vedotin-ejfv with your doctor.
  • You should be aware that even if you do not currently have diabetes, you could develop hyperglycemia (increases in blood sugar) while taking this drug. While having enfortumab vedotin-ejfv injection, report any of the following symptoms to your doctor right away: severe thirst, frequent urination, intense hunger, blurred vision, or weakness. In order to prevent the deadly illness known as ketoacidosis, it is crucial to contact your doctor as soon as you experience any of these symptoms. If it is not treated at an early stage, ketoacidosis could become life-threatening. Dry lips, nausea, vomiting, breath that smells like fruit, and diminished consciousness are all signs of ketoacidosis.
  • You should be aware that this drug may result in serious eye issues such as dry eyes and other eye issues. When you are receiving treatment with enfortumab vedotin-ejfv, your doctor could advise you to use artificial tears or lubricant eye drops.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

The injection of fortumab vedotin-ejfv may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Diarrhea
  • Vomiting
  • Nausea
  • Constipation
  • Reduced appetite
  • Slim down
  • Changing tastes
  • Hair fall
  • Arid skin
  • Unexpected exhaustion or fatigue

Some adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you have any of these symptoms or any of those listed in the SPECIAL PRECAUTIONS section:

  • Respiration difficulty
  • Breathing issues
  • Cough
  • Skin tone
  • Unexpected bruising or bleeding
  • Redness, swelling, fever, or pain at the injection site on the skin
  • Loss of vision, pain or redness in the eyes, or other visual alterations
  • Tingling, numbness, or burning in the feet or hands
  • Muscular trembling

Other negative effects from the injection of fortumab vedotin-ejfv are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What other information should I know?

Ask your pharmacist any inquiries you may have regarding the injection of enfortumab vedotin-ejfv.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Padcev®
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