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Endodan (Generic Oxycodone)

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Oxycodone is a potent opioid medication primarily used for managing moderate to severe pain. While it can be effective for pain relief, it also carries several risks, including:

  • Addiction: Oxycodone has a high potential for addiction and dependency. Prolonged use can lead to physical and psychological dependence, where individuals may feel compelled to continue using it despite negative consequences.
  • Respiratory depression: Oxycodone can slow down breathing, especially when taken in high doses or combined with other central nervous system depressants like alcohol or benzodiazepines. Respiratory depression can be life-threatening if not promptly addressed.
  • Tolerance: Over time, individuals may develop tolerance to the effects of oxycodone, requiring higher doses to achieve the same level of pain relief. This escalation in dosage increases the risk of overdose and other adverse effects.
  • Withdrawal symptoms: Abrupt discontinuation of oxycodone after prolonged use can lead to withdrawal symptoms such as anxiety, insomnia, muscle aches, sweating, nausea, vomiting, and diarrhea. Withdrawal can be extremely uncomfortable and may contribute to continued use of the drug.
  • Overdose: Taking too much oxycodone can result in overdose, characterized by severe respiratory depression, coma, and even death. Combining oxycodone with other drugs, especially other opioids or central nervous system depressants, further increases the risk of overdose.
  • Central nervous system effects: Oxycodone can cause drowsiness, dizziness, confusion, and impaired judgment, affecting a person’s ability to perform tasks requiring mental alertness, such as driving or operating machinery.
  • Gastrointestinal effects: Common side effects of oxycodone include constipation, nausea, and vomiting. Prolonged use can lead to gastrointestinal issues such as bowel obstruction or perforation.
  • Hormonal effects: Chronic use of opioids like oxycodone can disrupt hormonal balance, leading to issues such as reduced libido, infertility, and irregular menstrual cycles.

It’s essential for individuals prescribed oxycodone to use it exactly as directed by their healthcare provider, to be aware of the potential risks, and to seek medical attention if they experience any concerning symptoms. Additionally, alternatives for pain management, such as physical therapy, non-opioid medications, and psychological interventions, should be explored whenever possible to minimize the risks associated with opioids.

Why is this medication prescribed?

Oxycodone is prescribed primarily for the management of moderate to severe pain when other pain treatments, such as non-opioid analgesics, are not sufficient. It is commonly used for various medical conditions causing significant pain, including:

  • Chronic Pain: Oxycodone may be prescribed for chronic pain conditions such as osteoarthritis, rheumatoid arthritis, fibromyalgia, neuropathic pain, and low back pain.
  • Post-Surgical Pain: After surgical procedures, especially those involving significant tissue trauma, oxycodone may be prescribed to manage acute postoperative pain.
  • Cancer Pain: Oxycodone is often used to alleviate pain associated with cancer, including both cancer-related pain and pain resulting from cancer treatments such as surgery, chemotherapy, or radiation therapy.
  • Traumatic Injury: In cases of traumatic injury, such as fractures or severe burns, oxycodone may be prescribed to help manage the acute pain during the recovery process.
  • Palliative Care: Oxycodone may be part of the pain management regimen for patients receiving palliative care, focusing on relieving pain and improving the quality of life for individuals with advanced or terminal illnesses.

Oxycodone belongs to the class of medications known as opioids, which work by binding to specific receptors in the brain and spinal cord, effectively reducing the perception of pain. However, it’s essential to use oxycodone cautiously due to its potential for misuse, dependence, and addiction. Therefore, it should only be prescribed when other pain management options have been considered and under close medical supervision to minimize the risk of adverse effects and promote safe and effective pain relief.

How should this medicine be used?

As with any opioid medication, it’s crucial to follow the prescribing doctor’s instructions carefully to avoid misuse, dependency, and potential overdose. Here are some general guidelines for the use of oxycodone:

  • Dosage: The dosage of oxycodone prescribed will depend on various factors, including the severity of pain, the individual’s medical history, and their response to the medication. It is typically started at a low dose and adjusted gradually based on the patient’s needs and response.
  • Formulations: Oxycodone is available in various formulations, including immediate-release (IR) and extended-release (ER) formulations. Immediate-release oxycodone provides rapid pain relief and is usually taken every 4 to 6 hours as needed for pain. Extended-release formulations are designed to provide around-the-clock pain relief and are typically taken every 12 hours.
  • Administration: Oxycodone can be taken orally in the form of tablets or capsules. It’s essential to swallow the tablets whole with plenty of water and not to crush, chew, or break them, as this can lead to a rapid release of the medication, increasing the risk of overdose.
  • Avoid Alcohol: It’s crucial to avoid consuming alcohol while taking oxycodone, as it can increase the risk of side effects such as drowsiness, dizziness, and respiratory depression.
  • Monitoring: Patients should be closely monitored by their healthcare provider while taking oxycodone to assess the effectiveness of the medication, monitor for any adverse effects, and evaluate for signs of opioid misuse or dependency.
  • Discontinuation: Oxycodone should not be stopped abruptly without consulting a healthcare provider, as this can lead to withdrawal symptoms. Instead, the dosage should be tapered gradually under medical supervision to minimize withdrawal effects.
  • Storage: Oxycodone should be stored securely out of reach of children and pets, and it should not be shared with others, as it is a potent opioid medication with a high potential for misuse and addiction.

It’s essential for patients to communicate openly with their healthcare providers about their pain management needs, any concerns or side effects experienced while taking oxycodone, and any history of substance use disorder to ensure safe and effective use of the medication.

Other uses for this medicine

Some of the off-label uses of oxycodone may include:

  • Cough: Oxycodone may be used off-label as a cough suppressant, particularly in situations where other treatments have been ineffective. However, this use is less common due to the risk of respiratory depression and other side effects associated with opioids.
  • Severe Diarrhea: In some cases of severe diarrhea that does not respond to other treatments, oxycodone may be used to help slow down bowel motility and reduce diarrhea. However, this use is generally reserved for specific situations and closely monitored by healthcare providers.
  • Palliative Care: Oxycodone may be used off-label in palliative care settings to manage symptoms such as dyspnea (difficulty breathing) or agitation in patients with advanced illnesses, such as cancer or end-stage heart failure.

What special precautions should I follow?

When taking oxycodone, it’s crucial to follow special precautions to ensure safe and effective use of the medication. Here are some important precautions to keep in mind:

  • Follow Prescribing Instructions: Take oxycodone exactly as prescribed by your healthcare provider. Do not take more medication or take it more frequently than prescribed, as this can increase the risk of adverse effects, including overdose.
  • Avoid Alcohol: Alcohol can interact with oxycodone, increasing the risk of side effects such as drowsiness, dizziness, and respiratory depression. Avoid consuming alcohol while taking oxycodone.
  • Avoid Driving and Operating Machinery: Oxycodone can cause drowsiness, dizziness, and impaired judgment, which can affect your ability to drive or operate machinery safely. Avoid engaging in activities that require mental alertness until you know how oxycodone affects you.
  • Be Aware of Potential Interactions: Inform your healthcare provider about all other medications, supplements, and herbal products you are taking, as they may interact with oxycodone. Certain medications, such as benzodiazepines, other opioids, muscle relaxants, and certain antidepressants, can increase the risk of respiratory depression when taken with oxycodone.
  • Prevent Constipation: Opioid medications like oxycodone can cause constipation. To prevent constipation, drink plenty of water, eat a high-fiber diet, and engage in regular physical activity. Your healthcare provider may also recommend stool softeners or laxatives if needed.
  • Monitor for Side Effects: Pay attention to any side effects you experience while taking oxycodone, including drowsiness, dizziness, nausea, vomiting, constipation, and difficulty breathing. Contact your healthcare provider if you experience severe or concerning side effects.
  • Avoid Abrupt Discontinuation: Do not stop taking oxycodone suddenly without consulting your healthcare provider, as this can lead to withdrawal symptoms. Your healthcare provider can provide guidance on how to safely taper off the medication if needed.
  • Store Safely: Keep oxycodone out of reach of children and pets, and store it in a secure location away from heat, moisture, and light.
  • Be Cautious with Concurrent Medical Conditions: Inform your healthcare provider if you have a history of substance use disorder, respiratory conditions, liver or kidney disease, or any other medical conditions, as these may affect the safety and dosage of oxycodone.
  • Attend Regular Follow-Up Visits: Keep all scheduled appointments with your healthcare provider for monitoring and evaluation of your response to oxycodone and any potential adverse effects.

By following these precautions and communicating openly with your healthcare provider, you can help ensure the safe and effective use of oxycodone for pain management.

What special dietary instructions should I follow?

Regarding special dietary instructions for oxycodone, there are no specific dietary restrictions associated with its use. However, it’s essential to maintain a balanced diet and stay hydrated while taking oxycodone to support overall health and wellbeing.

What should I do if I forget a dose?

If you forget to take a dose of oxycodone, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed dose, as this can increase the risk of side effects or overdose. If you have any concerns or questions about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Oxycodone, like other opioid medications, can cause a range of side effects, ranging from mild to severe. It’s essential to be aware of these potential side effects and to discuss any concerns with your healthcare provider. Common side effects of oxycodone may include:

  • Drowsiness: Oxycodone can cause drowsiness or sedation, which may impair your ability to drive or operate machinery safely.
  • Dizziness: Some individuals may experience feelings of dizziness or lightheadedness while taking oxycodone.
  • Nausea and Vomiting: Gastrointestinal side effects such as nausea and vomiting are common with oxycodone use.
  • Constipation: Opioid medications like oxycodone can cause constipation, which may be alleviated with lifestyle modifications or over-the-counter medications.
  • Headache: Headaches are a relatively common side effect of oxycodone use.
  • Dry Mouth: Oxycodone can cause dry mouth, which may be relieved by staying hydrated or using sugar-free lozenges or gum.
  • Sweating: Some individuals may experience excessive sweating while taking oxycodone.
  • Itching: Itching or pruritus can occur as a side effect of oxycodone use.
  • Respiratory Depression: In high doses or when combined with other central nervous system depressants, oxycodone can cause respiratory depression, which is characterized by slow or shallow breathing. This is a potentially serious side effect that requires immediate medical attention.
  • Hypotension: Oxycodone may cause low blood pressure in some individuals.
  • Confusion: Some individuals may experience confusion or cognitive impairment while taking oxycodone.
  • Urinary Retention: Oxycodone can cause difficulty urinating or urinary retention, particularly in older adults or individuals with pre-existing urinary tract issues.
  • Dependence and Addiction: Prolonged use of oxycodone can lead to physical dependence and addiction, especially in individuals with a history of substance abuse or addiction.
  • Withdrawal Symptoms: Abrupt discontinuation of oxycodone can lead to withdrawal symptoms such as restlessness, irritability, anxiety, insomnia, sweating, chills, diarrhea, and flu-like symptoms.

It’s essential to report any side effects to your healthcare provider, especially if they are severe, persistent, or concerning. Your healthcare provider can provide guidance on managing side effects and may adjust your dosage or recommend alternative treatments if needed. Additionally, do not hesitate to seek medical attention if you experience signs of a severe allergic reaction, such as difficulty breathing, swelling of the face or throat, or a rash.

What should I know about storage and disposal of this medication?

Storage and disposal of oxycodone:

  • Storage: Keep oxycodone securely stored in a locked cabinet or other secure location, out of reach of children, pets, and individuals who may misuse it. Store oxycodone at room temperature away from moisture and heat. Do not freeze oxycodone.
  • Disposal: Dispose of unused or expired oxycodone properly to prevent accidental ingestion or misuse. You can dispose of oxycodone by following local guidelines for medication disposal. Many pharmacies and law enforcement agencies offer drug take-back programs for safe disposal. If a take-back program is not available, you can mix the unused medication with an undesirable substance (such as coffee grounds or cat litter) in a sealed plastic bag and throw it in the trash. Remove any personal information from the medication packaging before disposal.

In case of emergency/overdose

  • Call Emergency Services: If you suspect an overdose of oxycodone or someone is experiencing severe symptoms such as difficulty breathing, loss of consciousness, or unresponsiveness, call emergency services immediately (e.g., 911 in the United States).
  • Administer Naloxone: If you have access to naloxone, an opioid overdose reversal medication, administer it according to the instructions provided. Naloxone can temporarily reverse the effects of opioid overdose and is available as an injectable solution, nasal spray, or auto-injector device.
  • Provide Support: Stay with the individual until emergency medical help arrives. If the person is unconscious, place them in the recovery position on their side to help prevent choking on vomit.

What other information should I know?

  • Follow Prescribing Instructions: Take oxycodone exactly as prescribed by your healthcare provider. Do not adjust the dosage or frequency without consulting them first.
  • Avoid Alcohol: Avoid consuming alcohol while taking oxycodone, as it can increase the risk of side effects and overdose.
  • Driving and Operating Machinery: Be cautious when driving or operating machinery, as oxycodone may cause drowsiness, dizziness, or impaired judgment.
  • Medical Alert: Inform healthcare providers, including dentists and emergency responders, that you are taking oxycodone, as it can interact with other medications and affect treatment decisions.
  • Regular Follow-up: Attend regular follow-up appointments with your healthcare provider to monitor the effectiveness and safety of oxycodone therapy. Report any concerns or changes in symptoms promptly.

By following these guidelines and staying informed about oxycodone use, you can help ensure safe and effective pain management while minimizing the risk of adverse events or misuse.

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