PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Endep (Generic Amitriptyline)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Endep, also known as amitriptyline, is a tricyclic antidepressant primarily used to treat depression. Like all medications, it carries potential risks and side effects. Some of the risks associated with taking Endep include:

  • Side Effects: Endep can cause various side effects such as drowsiness, dizziness, dry mouth, blurred vision, constipation, weight gain, and sexual dysfunction.
  • Serotonin Syndrome: There’s a risk of developing serotonin syndrome, a potentially life-threatening condition characterized by agitation, hallucinations, rapid heart rate, elevated body temperature, and possibly coma, when Endep is taken with other drugs that increase serotonin levels.
  • Cardiovascular Effects: Tricyclic antidepressants like Endep can affect the heart, leading to irregular heartbeats, changes in blood pressure, and an increased risk of heart attack or stroke, especially in individuals with preexisting cardiovascular conditions.
  • Suicidal Thoughts: There’s a small risk of increased suicidal thoughts or behaviors, especially in young adults, when starting or adjusting the dosage of Endep. Patients should be closely monitored, especially during the initial stages of treatment.
  • Withdrawal Symptoms: Abruptly stopping Endep can lead to withdrawal symptoms such as nausea, headache, irritability, and flu-like symptoms. It’s important to gradually taper off the medication under medical supervision.
  • Interactions with Other Medications: Endep can interact with other medications, including certain antibiotics, antifungal drugs, and other antidepressants, potentially leading to adverse effects or reduced efficacy of either medication.
  • Risk of Overdose: Taking too much Endep can result in an overdose, which can be fatal. Symptoms of overdose include confusion, hallucinations, seizures, rapid or irregular heartbeat, and coma.

It’s crucial for individuals taking Endep to be monitored closely by their healthcare provider, to report any unusual symptoms or side effects promptly, and to follow their doctor’s instructions regarding dosage and discontinuation to minimize risks.

Why is this medication prescribed?

Endep, also known as amitriptyline, is a tricyclic antidepressant medication that is primarily prescribed to treat depression. However, it is also used off-label to manage other conditions such as chronic pain, migraines, insomnia, and certain anxiety disorders. Here’s a brief overview of its uses:

  • Depression: Endep is commonly prescribed to alleviate symptoms of depression, including persistent sadness, loss of interest or pleasure in activities, changes in appetite or weight, sleep disturbances, fatigue, feelings of worthlessness or guilt, and difficulty concentrating.
  • Chronic Pain: It can be used to manage various types of chronic pain conditions, such as neuropathic pain, fibromyalgia, and certain types of headaches. Endep works by altering the way the brain perceives pain signals.
  • Migraines: Endep is sometimes prescribed as a preventive medication for migraines, helping to reduce the frequency and severity of migraine attacks.
  • Insomnia: Due to its sedative effects, Endep may be prescribed off-label to help individuals with insomnia achieve better sleep quality and duration.
  • Anxiety Disorders: In some cases, Endep may be used to manage certain anxiety disorders, particularly when other medications have been ineffective.

How should this medicine be used?

Regarding how Endep should be used, it’s essential to follow your doctor’s instructions and the prescription label carefully. Here are some general guidelines:

  • Dosage: The dosage of Endep can vary depending on the condition being treated, the individual’s age, medical history, and response to the medication. It’s typically started at a low dose and gradually increased to achieve the desired therapeutic effect while minimizing side effects.
  • Administration: Endep is usually taken orally, either with or without food. It’s important to take it exactly as prescribed by your doctor and to not adjust the dosage or stop taking it without consulting your healthcare provider.
  • Duration of Treatment: The duration of Endep treatment can vary depending on the condition being treated and individual response. It’s essential to continue taking the medication as directed, even if you start to feel better, unless otherwise instructed by your doctor.
  • Monitoring: Your doctor may periodically monitor your progress and adjust the dosage accordingly. It’s essential to attend all follow-up appointments and to report any concerns or side effects to your healthcare provider promptly.
  • Discontinuation: If you need to stop taking Endep, your doctor will typically recommend gradually tapering off the medication to minimize the risk of withdrawal symptoms.

It’s important to note that Endep may interact with other medications and substances, so it’s essential to inform your doctor about all medications, supplements, and herbal products you are taking before starting Endep treatment.

Other uses for this medicine

In addition to depression, Endep may also be prescribed for other conditions such as:

  • Chronic pain: Endep can be effective in managing certain types of chronic pain conditions, such as neuropathic pain, migraines, and tension headaches.
  • Sleep disorders: Due to its sedative effects, Endep may be prescribed off-label for the treatment of insomnia or other sleep disorders.
  • Anxiety disorders: Endep may be used off-label in the treatment of certain anxiety disorders, although selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) are typically preferred for this indication.

What special precautions should I follow?

Regarding special precautions for taking Endep, it’s essential to follow your doctor’s instructions and take certain precautions to ensure safe and effective use. Here are some key considerations:

  • Medical History: Before starting Endep, inform your doctor about your complete medical history, including any preexisting conditions such as heart disease, liver or kidney problems, thyroid disorders, glaucoma, urinary retention, seizures, or a history of suicidal thoughts or behaviors.
  • Medication Interactions: Endep can interact with other medications, including monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), certain antibiotics, antifungal medications, antipsychotics, and medications that affect heart rhythm. Inform your doctor about all medications, supplements, and herbal products you are taking to avoid potentially harmful interactions.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of taking Endep with your doctor. Some studies suggest that Endep may be associated with certain risks during pregnancy, such as low birth weight and preterm birth, so your doctor will weigh the potential risks to the fetus against the benefits of treatment.
  • Suicidal Thoughts: Like many antidepressants, Endep carries a risk of increased suicidal thoughts or behaviors, especially in young adults. Be vigilant for any changes in mood or behavior, especially during the initial stages of treatment or when adjusting the dosage. Contact your doctor immediately if you experience worsening depression, agitation, irritability, or thoughts of self-harm.
  • Alcohol and Sedatives: Avoid consuming alcohol or using sedatives while taking Endep, as these substances can increase drowsiness and impair coordination, potentially leading to accidents or falls.
  • Driving and Operating Machinery: Endep may cause drowsiness, dizziness, or blurred vision, which can impair your ability to drive or operate machinery safely. Exercise caution when engaging in activities that require alertness until you know how Endep affects you.
  • Regular Monitoring: Your doctor may periodically monitor your progress and adjust the dosage as needed. Attend all follow-up appointments and report any concerns or side effects to your healthcare provider promptly.

By following these precautions and working closely with your healthcare provider, you can help ensure safe and effective use of Endep for your specific condition.

What special dietary instructions should I follow?

Special dietary instructions for Endep are generally not necessary. However, it’s essential to maintain a balanced diet and stay hydrated while taking this medication, as certain side effects such as constipation and dry mouth may occur. Avoid excessive caffeine intake, as it can worsen anxiety and sleep disturbances.

What should I do if I forget a dose?

If you forget to take a dose of Endep, take it as soon as you remember, unless it’s close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If you are unsure about what to do, consult your doctor or pharmacist for guidance. It’s important to try to take Endep consistently at the same time each day to maintain stable blood levels of the medication.

What side effects can this medication cause?

Endep (amitriptyline) can cause various side effects, ranging from mild to severe. It’s essential to be aware of these potential side effects and to discuss any concerns with your healthcare provider. Some common side effects of Endep include:

  • Drowsiness: One of the most common side effects of Endep is drowsiness or sedation, which can affect your ability to concentrate or perform tasks requiring alertness.
  • Dry Mouth: Endep can cause dry mouth, which may increase the risk of dental problems such as cavities or gum disease. Drinking water frequently and practicing good oral hygiene can help alleviate this side effect.
  • Blurred Vision: Endep may cause blurred vision or difficulty focusing, which can affect activities such as driving or reading.
  • Constipation: Endep can slow down bowel movements, leading to constipation. Increasing fiber intake, staying hydrated, and being physically active can help alleviate constipation.
  • Urinary Retention: Endep can affect bladder function, leading to difficulty urinating or urinary retention, especially in individuals with preexisting urinary issues.
  • Weight Gain: Some individuals may experience weight gain while taking Endep, although not everyone will experience this side effect.
  • Dizziness: Endep can cause dizziness or lightheadedness, especially when standing up quickly. Taking precautions such as rising slowly from a seated or lying position can help prevent falls.
  • Increased Heart Rate: Endep may cause tachycardia or increased heart rate, particularly at higher doses.
  • Orthostatic Hypotension: Endep can cause a drop in blood pressure upon standing, leading to dizziness or fainting. Taking precautions such as standing up slowly can help minimize this side effect.
  • Sexual Dysfunction: Endep may affect sexual function, leading to decreased libido, erectile dysfunction, or difficulty achieving orgasm.
  • Sweating: Some individuals may experience increased sweating while taking Endep.
  • Nausea and Vomiting: Endep can cause gastrointestinal symptoms such as nausea and vomiting, particularly when first starting the medication.
  • Headache: Headaches are a potential side effect of Endep, although they typically improve over time as your body adjusts to the medication.

It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects not listed here. If you experience any persistent or severe side effects while taking Endep, contact your healthcare provider for further evaluation and guidance. Additionally, if you experience any signs of allergic reaction (such as rash, itching, swelling, severe dizziness, or trouble breathing), seek immediate medical attention.

What should I know about storage and disposal of this medication?


  • Store Endep at room temperature away from light and moisture.
  • Keep Endep out of reach of children and pets.
  • Do not store Endep in the bathroom, as moisture and heat can degrade the medication.
  • Keep Endep in its original packaging or container to ensure proper identification.


  • Dispose of expired or unused Endep properly according to local guidelines or by consulting your pharmacist.
  • Do not flush Endep down the toilet or pour it down the drain unless instructed to do so by your pharmacist or local waste disposal company.

In case of emergency/overdose

  • In case of emergency or suspected overdose, contact your local poison control center or emergency room immediately.
  • Symptoms of Endep overdose may include extreme drowsiness, confusion, hallucinations, rapid heartbeat, seizures, and coma.
  • If possible, provide emergency personnel with information about the amount of Endep ingested, as well as any other medications or substances taken.

What other information should I know?

  • Inform all healthcare providers involved in your care that you are taking Endep, including doctors, dentists, and pharmacists.
  • Avoid abrupt discontinuation of Endep, as it may lead to withdrawal symptoms such as nausea, headache, irritability, and flu-like symptoms. Consult your doctor for guidance on tapering off the medication if necessary.
  • Attend all scheduled appointments with your doctor for monitoring of your condition and response to Endep therapy.
  • Be aware of potential interactions between Endep and other medications, supplements, or herbal products. Consult your doctor or pharmacist if you have any concerns.
  • Do not drive or operate machinery until you know how Endep affects you, as it may cause drowsiness, dizziness, or blurred vision.
  • Keep a list of all medications you are taking and carry it with you in case of emergency.
  • If you have any questions or concerns about Endep, consult your doctor or pharmacist for guidance.

By following these guidelines and staying informed about Endep, you can ensure safe and effective use of the medication for your specific condition.

Copyright © 2023