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Why is this medication prescribed?

When some varieties of melanoma (a type of skin cancer) have spread to other parts of the body or cannot be surgically removed, encorafenib and binimetinib (Mektovi) are used to treat the condition. It’s also used in conjunction with cetuximab (Erbitux) to treat a specific type of colon cancer in individuals that has progressed to other body areas after receiving another treatment or treatments. Kinase inhibitors, which include encorafenib, are a group of drugs. By preventing the aberrant protein from signaling the growth of cancer cells, it prevents cancer cells from spreading. The spread of cancer cells is slowed or stopped as a result.

How should this medicine be used?

Encorafenib is available as a pill to swallow. It is typically taken once day, with or without food. Encorafenib should be taken every day at at the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Exactly as prescribed, take encorafenib. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not take another dose of the drug if you vomit after taking it. Continue taking your medication as usual.

If you encounter any side effects, your doctor may reduce or temporarily or permanently discontinue your therapy. Throughout your encorafenib treatment, be careful to let your doctor know how you are feeling.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking encorafenib,

  • If you have any allergies, including to encorafenib, any other medications, or any of the chemicals in encorafenib capsules, notify your doctor right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
  • Inform your doctor if you have or have ever had liver illness, low blood potassium or magnesium levels, heart failure, or a QT prolongation (an abnormal heart rhythm that can cause fainting, loss of consciousness, seizures, or sudden death).
  • If you are pregnant or plan to become pregnant, let your doctor know. Before beginning treatment, you must take a pregnancy test. Throughout your encorafenib treatment and for two weeks after your last dose, you should take a nonhormonal birth control to avoid getting pregnant. It is especially crucial to utilize a nonhormonal method of birth control since encorafenib may reduce the effectiveness of oral contraceptives (birth control tablets). Consult your doctor about birth control options that are right for you. Call your doctor right away if you become pregnant while taking encorafenib. The fetus could suffer from encorafenib.
  • If you are breastfeeding, let your doctor know. Encorafenib should not be taken for two weeks after your last dose and while you are breastfeeding.
  • You should be aware that this drug can make males less fertile. The dangers of using encorafenib should be discussed with your doctor.

What special dietary instructions should I follow?

While using this medication, avoid grapefruit and grapefruit juice.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If your next dose is less than 12 hours away, skip the missed dose and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Side effects are possible with encorafenib. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Fatigue
  • Fever
  • Nausea
  • Vomiting
  • Abdominal pain
  • Constipation
  • Reduction in appetite
  • Headache
  • Dizziness
  • Thinning of the skin
  • Rash
  • Irritation or dry skin
  • Hair fall
  • Muscular or joint ache
  • Shift in preference
  • Leg, arm, or back pain
  • Acne
  • Arm, hand, foot, or leg numbness, burning, or tingling
  • Having trouble falling or staying asleep

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Sense of faintness or dizziness
  • Vision alterations
  • Skin modifications such a new wart, an infected or persistently reddish lump, or a change in the size or color of a mole
  • Uncommon bruising or bleeding
  • Bloody, dark, or tarry stools
  • Spitting blood
  • A nosebleed
  • Hands and feet’s soles may exhibit skin peeling, numbness, edema, and redness

The chance of getting cancer, including skin cancer, may increase when taking encorafenib. Your doctor will examine your skin for symptoms of skin cancer before treatment, every 2 months while you are receiving encorafenib, and for up to 6 months after your last dosage. Discuss the dangers of using this drug with your doctor.

Other adverse effects of encorafenib could exist. If you have any strange side effects while taking this medicine, call your doctor right away.

The Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program is available online at or by phone at 1-800-332-1088 if you or your doctor notice a serious side effect.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. Removing the desiccant (drying agent) from the bottle is not advised.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilizing a medicine take-back program is the easiest approach to get rid of your medication. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with the lab, your physician, and your eye doctor. Before you start your therapy, your doctor will run a lab test to determine whether encorafenib can treat your cancer. To monitor your body’s reaction to encorafenib, your doctor may request specific blood tests, such as eye checks.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every drug you take, including prescription and nonprescription (over-the-counter) medications, vitamins, minerals, and other dietary supplements. Every time you see a doctor or are admitted to the hospital, you should carry this list with you. Additionally, it is crucial to have this knowledge on hand in case of emergency.

Brand names

  • Braftovi®
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