Why is this medication prescribed?

Encorafenib is a medication primarily prescribed for the treatment of certain types of cancer, particularly melanoma with a specific genetic mutation called BRAF V600E or V600K mutation. It is used in combination with another medication called binimetinib for this purpose.

Encorafenib belongs to a class of medications known as kinase inhibitors. It works by blocking the action of a protein called BRAF, which plays a role in the growth and spread of cancer cells.

How should this medicine be used?

Here are some general guidelines for how Encorafenib is used:

• Dosage: The dosage of Encorafenib can vary depending on factors such as the patient’s weight, overall health, and the specific type and stage of cancer being treated. It is typically taken orally in the form of tablets.
• Administration: Encorafenib is usually taken once daily, with or without food. The tablets should be swallowed whole with a glass of water, and they should not be crushed, chewed, or broken.
• Follow doctor’s instructions: It is important to follow the dosage and administration instructions provided by the doctor or healthcare provider carefully. Do not adjust the dosage or stop taking the medication without consulting your doctor first.
• Regular monitoring: While taking Encorafenib, patients may require regular monitoring of their blood counts, liver function, and other parameters to ensure the medication is working effectively and to monitor for any potential side effects.
• Adverse effects: Like all medications, Encorafenib can cause side effects. Common side effects may include nausea, vomiting, diarrhea, fatigue, headache, and joint pain. It is important to report any persistent or severe side effects to the doctor.
• Drug interactions: Encorafenib may interact with other medications, including over-the-counter drugs and herbal supplements. Patients should inform their doctor about all medications and supplements they are taking before starting Encorafenib.
• Pregnancy and breastfeeding: Encorafenib may harm an unborn baby, so it is important to use effective contraception while taking this medication. It is also not recommended for use during breastfeeding.

As always, it is crucial for patients to discuss any questions or concerns about Encorafenib with their doctor or healthcare provider. They can provide personalized guidance based on the individual’s specific medical history and circumstances.

Other uses for this medicine

Apart from its primary use in the treatment of melanoma, Encorafenib may also be investigated for its efficacy in other types of cancers. However, its primary approval and usage are for melanoma treatment.

What special precautions should I follow?

As for special precautions to follow while taking Encorafenib, here are some important considerations:

• Pregnancy and breastfeeding: Encorafenib can cause harm to an unborn baby, so it is essential to use effective contraception during treatment and for some time afterward. It is not recommended for use during pregnancy. Similarly, breastfeeding should be avoided while taking Encorafenib.
• Liver function: Encorafenib can affect liver function, leading to liver toxicity. Therefore, regular monitoring of liver function tests is necessary during treatment. Patients should promptly report any signs or symptoms of liver problems, such as jaundice (yellowing of the skin or eyes), dark urine, abdominal pain, or unusual fatigue.
• Heart problems: Encorafenib may cause heart problems, including heart rhythm abnormalities (arrhythmias) or decreased heart function (heart failure). Patients with a history of heart disease or risk factors for heart disease should be closely monitored during treatment.
• Eye problems: Some patients may experience vision changes or eye problems while taking Encorafenib, including retinal detachment or retinal vein occlusion. It is essential to report any changes in vision or eye symptoms to the doctor promptly.
• Skin reactions: Encorafenib can cause skin reactions, including rash, dry skin, and photosensitivity (increased sensitivity to sunlight). Patients should protect their skin from sunlight and report any severe or persistent skin reactions to their doctor.
• Interactions with other medications: Encorafenib may interact with other medications, including over-the-counter drugs, herbal supplements, and prescription medications. Patients should inform their doctor about all medications they are taking before starting Encorafenib.
• Dose adjustments: Dose adjustments may be necessary based on factors such as liver function, kidney function, and the presence of other medical conditions. Patients should follow their doctor’s instructions regarding dosing carefully.

It is essential to discuss any questions or concerns about Encorafenib and its potential uses and precautions with your doctor or healthcare provider. They can provide personalized guidance based on your individual medical history and circumstances.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Encorafenib. However, maintaining a healthy and balanced diet is important for overall health and well-being during cancer treatment. It is advisable to consult with a healthcare provider or a registered dietitian for personalized dietary advice.

What should I do if I forget a dose?

If you miss a dose of Encorafenib, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, consult your doctor or healthcare provider for guidance.

What side effects can this medication cause?

Encorafenib, like many medications, can cause side effects. Some common side effects of Encorafenib may include:

• Nausea and vomiting: Mild to moderate nausea and vomiting are common side effects of Encorafenib. These symptoms can often be managed with anti-nausea medications.
• Diarrhea: Encorafenib may cause diarrhea, which can range from mild to severe. It is important to stay hydrated and report any persistent or severe diarrhea to your doctor.
• Fatigue: Feeling tired or fatigued is a common side effect of Encorafenib. It is essential to get enough rest and conserve energy while undergoing treatment.
• Skin changes: Encorafenib can cause skin reactions, such as rash, dry skin, and photosensitivity (increased sensitivity to sunlight). Protecting your skin from sunlight and using moisturizers may help alleviate these symptoms.
• Joint pain: Some patients may experience joint pain or discomfort while taking Encorafenib. Over-the-counter pain relievers or anti-inflammatory medications may help manage this symptom.
• Fever: Fever is a possible side effect of Encorafenib. Contact your doctor if you experience a persistent or high fever.
• Headache: Headaches are another common side effect of Encorafenib. Drinking plenty of fluids and getting adequate rest may help alleviate this symptom.
• Changes in liver function: Encorafenib can affect liver function, leading to elevated liver enzymes. Regular monitoring of liver function tests is necessary during treatment.
• Eye problems: Some patients may experience vision changes or eye problems while taking Encorafenib, such as blurred vision or dry eyes. Report any changes in vision or eye symptoms to your doctor.
• Cardiac events: Encorafenib may cause heart problems, including heart rhythm abnormalities or decreased heart function. Patients with a history of heart disease or risk factors should be closely monitored during treatment.

It is important to discuss any concerns or questions about side effects with your doctor or healthcare provider. They can provide guidance on managing side effects and may adjust your treatment regimen if necessary.

What should I know about storage and disposal of this medication?

Here’s what you should know about storage and disposal of Encorafenib:

• Storage: Store Encorafenib tablets at room temperature, away from moisture, heat, and light. Keep the medication in its original container, and ensure it is tightly closed when not in use. Do not store Encorafenib in the bathroom or kitchen, where moisture and heat can affect its stability.
• Disposal: Dispose of any unused or expired Encorafenib tablets properly according to local regulations or guidelines. Do not flush medications down the toilet or pour them down the drain unless instructed to do so. Instead, consult your pharmacist or local waste disposal facility for guidance on how to safely dispose of medications.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms such as severe nausea or vomiting, severe diarrhea, fainting, or difficulty breathing, seek immediate medical attention or contact your local poison control center.

What other information should I know?

• Follow-up appointments: Keep all scheduled appointments with your doctor for regular check-ups and monitoring while taking Encorafenib. Your doctor may need to adjust your dosage or monitor for side effects during treatment.
• Lab tests: You may need to undergo regular blood tests, liver function tests, and other laboratory tests while taking Encorafenib to monitor your body’s response to the medication and detect any potential side effects.
• Avoid grapefruit: Grapefruit and grapefruit juice can interact with Encorafenib and increase the risk of side effects. Avoid consuming grapefruit or grapefruit products while taking this medication.
• Inform healthcare providers: Make sure to inform all healthcare providers involved in your care, including doctors, dentists, and pharmacists, that you are taking Encorafenib. This includes any new medications or supplements you may start during treatment.
• Pregnancy and breastfeeding: Encorafenib can harm an unborn baby, so it is important to use effective contraception during treatment and avoid becoming pregnant. It is also not recommended for use during breastfeeding.
• Driving and operating machinery: Encorafenib may cause dizziness or fatigue, which can impair your ability to drive or operate machinery safely. Avoid driving or engaging in activities that require mental alertness until you know how this medication affects you.

Always follow your doctor’s instructions and ask any questions you may have about taking Encorafenib safely and effectively.