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Enalapril and Hydrochlorothiazide

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If you are pregnant, avoid using enalapril with hydrochlorothiazide. Call your doctor right away if you fall pregnant while taking enalapril and hydrochlorothiazide. The foetus could be harmed by enalapril and hydrochlorothiazide.

Why is this medication prescribed?

Enalapril and hydrochlorothiazide are taken together to treat high blood pressure. Enalapril belongs to the angiotensin-converting enzyme (ACE) inhibitors drug class. It functions by lowering specific molecules that stiffen blood arteries, allowing blood to flow more freely. Diuretics, also known as “water pills,” are a class of drugs that includes hydrochlorothiazide. It functions by causing the kidneys to excrete salt and water from the body through the urine.

High blood pressure is a common illness that, if left untreated, can harm the kidneys, brain, heart, blood vessels, and other organs. Heart disease, a heart attack, heart failure, a stroke, renal failure, eyesight loss, and other issues may result from damage to these organs. Making lifestyle modifications will help you control your blood pressure in addition to taking medication. These adjustments include quitting smoking, drinking alcohol in moderation, eating a diet low in fat and salt, keeping a healthy weight, and exercising for at least 30 minutes most days.

How should this medicine be used?

Enalapril and hydrochlorothiazide are packaged as a tablet for oral consumption. Once or twice a day, it is often taken with or without meals. Take enalapril with hydrochlorothiazide at roughly the same time(s) every day to help you remember to take them. Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Take hydrochlorothiazide and enalapril precisely as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

High blood pressure is not cured but is managed by enalapril and hydrochlorothiazide. Even if you feel good, you should still take hydrochlorothiazide and enalapril. Without consulting your doctor, do not discontinue taking hydrochlorothiazide and enalapril.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking enalapril and hydrochlorothiazide,

  • If you have an allergy to any of the following drugs: enalapril (Vasotec, in Vaseretic); hydrochlorothiazide (HCTZ, Microzide, Oretic); angiotensin-converting enzyme (ACE) inhibitors include benazepril (Lotensin, in Lotrel), captopril, fosinopril, lisinopril (in Prinzide, in Zestoretic), and fosinopril (Monopril), quinapril (Accupril, in Accuretic, in Quinaretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), ramipril (Altace), and trandolapril (Mavik, in Tarka); any other pharmaceuticals, sulfa medications, or any component of the tablets containing enalapril and hydrochlorothiazide. Request a list of the ingredients from your chemist.
  • If you are using valsartan and sacubitril (Entresto), or if you have stopped taking it within the last 36 hours, let your doctor or chemist know. If you are also on valsartan and sacubitril, your doctor generally won’t let you take enalapril and hydrochlorothiazide. Additionally, let your physician know if you have diabetes and are taking aliskiren (Tekturna, in Amturnide, Tekamlo, Tekturna HCT). If you have diabetes and also take aliskiren, your doctor will likely advise you to avoid mixing enalapril with hydrochlorothiazide.
  • Inform your doctor and chemist about any vitamins, nutritional supplements, herbal items, and prescription and over-the-counter drugs you are using. Any of the following should be mentioned: NSAIDs like indomethacin (Indocin, Tivorbex), aspirin, and other non-steroidal anti-inflammatory drugs (NSAIDs); colestipol (Colestid), cholestyramine (Prevalite), diuretics (water pills), insulin, or other diabetes drugs; other treatments for high blood pressure; lithium (Lithobid); oral steroids such dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); phenobarbital (Luminal), painkillers, and potassium supplements. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have or have ever had heart, parathyroid, liver, renal, lupus, diabetes, allergies, asthma, gout, or angioedema (a condition that causes hives, breathing difficulties, and severe swelling of the face, lips, neck, tongue, hands, or feet), let your doctor know.
  • Inform your doctor if you are nursing a baby.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking enalapril and hydrochlorothiazide.
  • Inquire with your doctor if drinking alcohol is okay for you to do so while taking enalapril and hydrochlorothiazide. Enalapril and hydrochlorothiazide adverse effects can be exacerbated by alcohol.
  • You should be aware that a reduction in blood pressure might result from diarrhoea, vomiting, dehydration, and excessive perspiration, which can make you feel faint and dizzy.

What special dietary instructions should I follow?

Before using salt substitutes containing potassium, consult your doctor. Follow these instructions closely if your doctor advises a low-salt or low-sodium diet.

What should I do if I forget a dose?

As soon as you recall, take the missed dose. Skip the missed dose and carry on with your regular dosing plan, nevertheless, if it is almost time for the subsequent dose. Never take two doses at once to make up for missing ones.

What side effects can this medication cause?

Hydrochlorothiazide and enalapril may have potential adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Cough
  • Dizziness
  • Headache
  • Extreme fatigue
  • Muscular pain
  • Reduction in sexual capacity

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Lightheadedness
  • Edema of the hands, feet, ankles, lower legs, cheeks, neck, tongue, lips, and eyes
  • Hoarseness
  • Breathing or swallowing challenges
  • Infection symptoms such a fever, sore throat, chills, and others
  • Eyes or skin that have a yellow tint
  • Mouth ache
  • Thirst
  • Weakness
  • Sporadic urination
  • Uneasy stomach
  • Vomiting
  • Fainting
  • Chest ache
  • Rapid or erratic heartbeat

Hydrochlorothiazide with enalapril may also have other adverse effects. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilizing a medicine take-back program is the easiest approach to get rid of your medication. To find out about take-back programs in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. You should have your blood pressure monitored frequently to monitor how enalapril and hydrochlorothiazide are working for you. To determine how your body is responding to enalapril with hydrochlorothiazide, your doctor may request specific lab tests.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Vaseretic®
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