PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Enalapril and Hydrochlorothiazide

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Enalapril and hydrochlorothiazide are medications used to treat high blood pressure and other cardiovascular conditions. While they can be effective in managing these conditions, they also carry certain risks:

  • Low Blood Pressure (Hypotension): Both medications can cause a drop in blood pressure, which may lead to symptoms such as dizziness, lightheadedness, or fainting.
  • Electrolyte Imbalance: Hydrochlorothiazide is a diuretic that can cause the body to lose potassium, sodium, and magnesium, leading to electrolyte imbalances. This can result in symptoms like muscle weakness, cramps, and irregular heartbeat.
  • Kidney Function: Enalapril and hydrochlorothiazide can affect kidney function, especially in individuals with pre-existing kidney disease. They may reduce the kidneys’ ability to filter blood, leading to worsening kidney function or even kidney failure in severe cases.
  • Allergic Reactions: Some people may experience allergic reactions to these medications, which can range from mild skin rashes to more severe symptoms like swelling of the face, lips, or throat (angioedema), which can be life-threatening.
  • Hyperkalemia: Enalapril can sometimes lead to an increase in potassium levels in the blood, known as hyperkalemia. High levels of potassium can cause symptoms like weakness, numbness, or an irregular heartbeat.
  • Interaction with Other Medications: Enalapril and hydrochlorothiazide may interact with other medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or potassium supplements, potentially causing adverse effects or reducing the effectiveness of one or both medications.
  • Pregnancy Risks: These medications are not recommended during pregnancy, especially during the second and third trimesters, as they can harm the developing fetus and lead to complications such as birth defects or low blood pressure in the newborn.

It’s essential to take these medications exactly as prescribed by a healthcare professional and to discuss any concerns or potential side effects with them. Additionally, regular monitoring of blood pressure, kidney function, and electrolyte levels may be necessary to ensure the safe and effective use of these medications

Why is this medication prescribed?

Enalapril and hydrochlorothiazide are commonly prescribed together as a combination medication to treat high blood pressure (hypertension).

  • Enalapril: This medication belongs to a class of drugs known as ACE inhibitors (angiotensin-converting enzyme inhibitors). It works by relaxing blood vessels, which helps to lower blood pressure and improve blood flow.
  • Hydrochlorothiazide: Hydrochlorothiazide is a diuretic, also known as a water pill. It helps the body to remove excess salt and water by increasing urine production, which can lower blood pressure.

These two medications work synergistically to lower blood pressure through different mechanisms, making them an effective combination for managing hypertension.

How should this medicine be used?

How to Use Enalapril and Hydrochlorothiazide:

  • These medications are typically taken by mouth, usually once a day.
  • They can be taken with or without food, but it’s essential to take them consistently at the same time each day.
  • The dosage prescribed will depend on factors such as the severity of hypertension, individual response to the medication, and any other medical conditions the person may have.
  • It’s crucial to follow the dosage instructions provided by the healthcare provider and not to exceed the prescribed dose.
  • It may take several weeks for these medications to reach their full effect, so it’s essential to continue taking them even if blood pressure appears to be under control.
  • If a dose is missed, it should be taken as soon as remembered unless it is close to the time for the next dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. Doubling up on doses should be avoided.
  • Regular monitoring of blood pressure, kidney function, and electrolyte levels may be necessary while taking these medications.

As with any prescription medication, it’s essential to follow the healthcare provider’s instructions carefully and to discuss any questions or concerns about the use of Enalapril and Hydrochlorothiazide with them. Additionally, do not stop taking these medications abruptly without consulting a healthcare professional, as it could lead to worsening of hypertension or other complications.

Other uses for this medicine

  • Enalapril and hydrochlorothiazide are primarily used to treat high blood pressure. However, they may also be prescribed for other conditions such as congestive heart failure and to protect the kidneys in patients with diabetes.
  • Enalapril can also be used in the treatment of asymptomatic left ventricular dysfunction to improve symptoms and reduce the risk of heart failure.

What special precautions should I follow?

Special Precautions for Enalapril and Hydrochlorothiazide:

  • Allergies: Inform your healthcare provider if you have allergies to enalapril, hydrochlorothiazide, or any other medications. Allergic reactions to these medications can be serious and potentially life-threatening.
  • Pregnancy and Breastfeeding: Enalapril and hydrochlorothiazide are not recommended during pregnancy, especially during the second and third trimesters, as they can harm the developing fetus. They should also be avoided while breastfeeding, as they may pass into breast milk and harm the infant.
  • Kidney or Liver Disease: Individuals with impaired kidney or liver function may require dosage adjustments or closer monitoring while taking these medications.
  • Electrolyte Imbalance: Regular monitoring of electrolyte levels, particularly potassium, is essential, as hydrochlorothiazide can cause electrolyte imbalances. This is especially important for individuals with conditions such as kidney disease or those taking other medications that affect electrolyte levels.
  • Dehydration: Hydrochlorothiazide can increase urine production, potentially leading to dehydration, especially in hot weather or with vigorous exercise. It’s important to drink plenty of fluids while taking this medication.
  • Blood Pressure Monitoring: Regular monitoring of blood pressure is necessary while taking enalapril and hydrochlorothiazide to ensure that blood pressure is adequately controlled and to detect any potential complications.
  • Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with enalapril and hydrochlorothiazide, potentially affecting their effectiveness or increasing the risk of side effects.

Following these precautions and guidelines can help ensure the safe and effective use of enalapril and hydrochlorothiazide for the intended purpose under the supervision of a healthcare professional.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with taking enalapril and hydrochlorothiazide. However, it’s generally recommended to follow a healthy, balanced diet low in sodium and high in fruits, vegetables, and whole grains to help manage blood pressure.

What should I do if I forget a dose?

If you forget to take a dose of enalapril and hydrochlorothiazide, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance. It’s important to maintain a consistent dosing schedule to ensure the effectiveness of the medication in controlling blood pressure.

What side effects can this medication cause?

Enalapril and hydrochlorothiazide, like any medications, can cause side effects. It’s important to note that not everyone will experience these side effects, and some may experience them to varying degrees of severity. Common side effects of enalapril and hydrochlorothiazide may include:

  • Dizziness or lightheadedness: This can occur due to a drop in blood pressure, especially when standing up quickly from a sitting or lying position.
  • Fatigue or weakness: Some individuals may feel tired or weak, particularly when starting the medication or with changes in dosage.
  • Dry cough: Enalapril can sometimes cause a persistent dry cough, which may be bothersome for some individuals.
  • Increased urination: Hydrochlorothiazide is a diuretic, which increases urine production. This may lead to more frequent urination.
  • Electrolyte imbalances: Hydrochlorothiazide can cause imbalances in electrolytes such as potassium, sodium, and magnesium, which may result in symptoms like muscle weakness, cramps, or irregular heartbeat.
  • Headache: Some individuals may experience headaches while taking these medications.
  • Nausea or vomiting: These gastrointestinal symptoms can occur, especially when first starting the medication.
  • Skin rash or itching: Allergic reactions to enalapril and hydrochlorothiazide can manifest as skin rashes or itching.
  • Changes in blood glucose levels: Enalapril and hydrochlorothiazide may affect blood sugar levels, particularly in individuals with diabetes.
  • Kidney function: In some cases, these medications can affect kidney function, particularly in individuals with pre-existing kidney disease.
  • Photosensitivity: Some individuals may become more sensitive to sunlight while taking hydrochlorothiazide, leading to sunburn or skin reactions.
  • Changes in blood lipid levels: These medications may cause changes in blood cholesterol and triglyceride levels in some individuals.

It’s important to report any persistent or bothersome side effects to your healthcare provider. Additionally, seek immediate medical attention if you experience symptoms of a severe allergic reaction, such as swelling of the face, lips, tongue, or throat; difficulty breathing; or severe dizziness. Your healthcare provider can provide guidance on managing side effects and may adjust your treatment regimen if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Enalapril and Hydrochlorothiazide:

  • Store enalapril and hydrochlorothiazide at room temperature away from light and moisture.
  • Keep the medications in their original packaging or container to protect them from moisture and contamination.
  • Keep them out of reach of children and pets.
  • Do not store enalapril and hydrochlorothiazide in the bathroom or near the kitchen sink, where they may be exposed to moisture or heat.
  • Follow any specific storage instructions provided by your pharmacist or healthcare provider.
  • When it comes to disposal, follow local regulations or guidelines for the safe disposal of medications. Do not flush medications down the toilet unless instructed to do so. Instead, consult with your pharmacist or local waste disposal facility for proper disposal methods.

In case of emergency/overdose

  • If you suspect an overdose of enalapril and hydrochlorothiazide or experience severe symptoms such as fainting, extreme dizziness, difficulty breathing, or irregular heartbeat, seek emergency medical attention immediately.
  • Contact your local poison control center or emergency room for guidance on what to do next.
  • Be prepared to provide information about the dosage of medication taken and when it was ingested.

What other information should I know?

  • Inform all healthcare providers involved in your care, including dentists and pharmacists, that you are taking enalapril and hydrochlorothiazide. This helps to prevent potential drug interactions or complications.
  • Attend regular follow-up appointments with your healthcare provider to monitor your blood pressure, kidney function, and electrolyte levels while taking these medications.
  • Do not share your medications with others, even if they have similar symptoms, as it may be harmful to them.
  • Keep a list of all medications you are taking, including prescription drugs, over-the-counter medications, and supplements, and review it with your healthcare provider regularly.
  • If you have any questions or concerns about enalapril and hydrochlorothiazide or your treatment regimen, do not hesitate to discuss them with your healthcare provider or pharmacist.

By following these guidelines and staying informed about your medication, you can help ensure the safe and effective use of enalapril and hydrochlorothiazide for managing your condition.

Copyright © 2023