PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Emsam (Generic Selegiline Transdermal Patch)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!


If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


During clinical investigations, a tiny number of kids, teenagers, and young adults (up to 24 years old) who took antidepressants (also known as “mood elevators”) such transdermal selegiline developed suicide thoughts, plans, or attempts. Children, teenagers, and young adults who take antidepressants to treat depression or other mental diseases may have a higher risk of committing suicide than those who do not take these medications. However, experts disagree on how significant this risk is and how much it has to be taken into account when determining whether or not a kid or adolescent should take an antidepressant. Transdermal selegiline is often not recommended for use in children under the age of 18, although in some circumstances, a doctor may determine that it is the best treatment option for a child’s illness.

Even if you are an adult above the age of 24, you should be aware that taking transdermal selegiline or other antidepressants may cause your mental health to shift in unexpected ways. Suicidal thoughts may come to mind, especially at the start of treatment and whenever your dose is changed. Any of the following symptoms should prompt you, your family, or your caregiver to call your doctor immediately away: Depression that is either new or getting worse, thoughts of self-harm or suicide, plans or attempts to do so, excessive worry, agitation, panic attacks, trouble falling or staying asleep, aggressive behavior, irritability, acting without thinking, extreme restlessness, and frenzied abnormal excitement. When you are unable to seek treatment on your own, make sure your family or caregiver knows which symptoms may be serious so they can call the doctor.

While you are on transdermal selegiline, your doctor will want to visit you frequently, especially at the start of your treatment. Be sure to show up for all of your doctor’s appointment times.

When you start transdermal selegiline therapy, your doctor or pharmacist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. The FDA website also offers the Medication Guide.

No of your age, you, your parent, or your caregiver should discuss the advantages and disadvantages of treating your disease with an antidepressant or with alternative treatments with your doctor before starting an antidepressant. The dangers and advantages of not treating your ailment should also be discussed. You should be aware that your chance of committing suicide is significantly increased if you suffer from depression or any mental disorder. This risk is increased if you or a family member currently has, or previously had, bipolar disorder (depression followed by periods of extreme excitement) or mania (frenzied, abnormally excited mood), or if you have ever considered or tried suicide. Discuss your ailment, symptoms, and personal and family medical history with your doctor. You and your doctor will decide on the best course of action for you.

Why is this medication prescribed?

Selegiline is administered transdermally to treat depression. The group of drugs known as monoamine oxidase (MAO) inhibitors includes selegiline. It functions by boosting the levels of specific organic compounds required to preserve mental equilibrium.

How should this medicine be used?

Selegiline for transdermal use is available as a skin-applying patch. Typically, it is applied once daily and left on for 24 hours. Apply a fresh patch of selegiline at roughly the same time each day after removing the previous one. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Use selegiline transdermally exactly as instructed. Applying patches more frequently than advised by your doctor is not recommended.

Transdermal selegiline may be administered by your doctor at first at a low dose and subsequently increased, but no more frequently than once every two weeks.

Selegiline applied topically manages depression but does not treat it. After a week or more of transdermal selegiline treatment, your condition may start to get better. Even if you feel good, you should keep using transdermal selegiline. Transdermal selegiline should not be stopped without consulting your doctor.

Anywhere on your upper chest, back (between your neck and your waist), upper thigh, or outer surface of your upper arm, apply selegiline patches to dry, smooth skin. Select a location where clothing that is too tight won’t rub the patch. On skin that is hairy, greasy, inflamed, broken, scarred, or calloused, selegiline patches should not be used.

Once a selegiline patch has been applied, it should be worn continuously until you are ready to take it off and apply a new patch. Try pressing the patch back into place with your fingertips if it becomes loose or comes off before it needs to be replaced. Apply a fresh patch to a different spot if the patch cannot be pressed back on. At your regularly scheduled patch change time, replace the new patch.

Keep selegiline patches intact.

Avoid direct heat sources including heating pads, electric blankets, heat lamps, saunas, hot tubs, and heated water beds when wearing a selegiline patch. Don’t leave the patch in the sun for too long.

Follow these steps to apply the patches:

  1. Pick the location where the patch will be applied. Use soap and warm water to clean the area. Remove all of the soap with water, then pat the area dry with a fresh towel.
  2. The patch should be taken out of the protective pouch.
  3. On the sticky side of the patch, peel back the first sheet of lining. The patch should still have a second liner strip attached to it.
  4. With the adhesive side down, firmly press the patch onto your skin. Avoid letting your fingers touch the sticky side.
  5. Press the remaining portion of the patch’s sticky side firmly against your skin after removing the second piece of protective liner. Make sure the patch is properly fastened and that it is pressed flat against the skin without any lumps or wrinkles.
  6. To get any medication off your hands that may have gotten on them, wash them with soap and water. After washing your hands, refrain from touching your eyes.
  7. Peel the patch off softly and gently after 24 hours. The patch should be carefully disposed of out of the reach of children and animals by folding it in half with the sticky sides together. If kids or animals chew, play with, or wear old patches, they could get hurt.
  8. To get rid of any residue, wash the area that was underneath the patch with warm water and mild soap. If necessary, you can remove residue that won’t wash off with soap and water by using baby oil or a medical adhesive remover pad. Avoid using solvents like nail polish remover or alcohol.
  9. Immediately apply a fresh patch to a different location by performing steps 1 through 6.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using transdermal selegiline,

  • If you have an allergy to selegiline or any other drug, let your doctor and pharmacist know right away.
  • Inform your doctor if you are now taking, recently have taken, or intend to take any of the following prescription and over-the-counter drugs, herbal remedies, or dietary supplements: amphetamines (stimulants, “uppers”) like methamphetamine (Desoxyn), benzphetamine (Didrex), dextroamphetamine (Dexedrine, Dextrostat), amphetamine (in Adderall), antidepressants like amitriptyline (Elavil), imipramine (Tofranil), buproprion (Wellbutrin, Zyban), and buspirone (BuSpar); medication for cold and flu symptoms or for weight reduction, such as carbamazepine (Tegretol), cyclobenzaprine (Flexeril), dextromethorphan (Robitussin), meperidine (Demerol), and methadone (Dolophine); other monoamine oxidase inhibitors include phenelzine (Nardil), isocarboxazid (Marplan), and mirtazapine (Remeron), oral tranylcypromine (Parnate), oxcarbazepine (Trileptal), and selegiline (Eldepryl, Zelapar), as well as pentazocine (Talwin); selective serotonin reuptake medications like fluoxetine (Prozac), citalopram (Celexa), escitalopram (Lexapro), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); propoxyphene (Darvon); tramadol (Ultram, in Ultracet), St. John’s wort, and selective serotonin and norepinephrine reuptake inhibitors (SSNRIs), such as duloxetine (Cymbalta) and venlafaxine (Effexor); supplements for tyramine, etc. Your physician might advise against using transdermal selegiline until one or more weeks have passed since your previous dose of one of these drugs. Your doctor will likely advise against using any of these medications for at least two weeks after you stop using transdermal selegiline if you stop using it.
  • Inform your doctor and pharmacist about any additional prescription drugs, over-the-counter remedies, and vitamins you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • You should be aware that selegiline may linger in your body for a number of weeks after you stop taking it. Tell your doctor and pharmacist that you recently finished using selegiline during the first few weeks after your treatment is over before you begin taking any new medications.
  • If you have or have previously had a pheochromocytoma (a tumor on a tiny gland near the kidneys), let your doctor know. You could be advised by your doctor not to use transdermal selegiline.
  • Inform your doctor if you frequently feel lightheaded or faint, have seizures, have had a heart attack, or have heart problems.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you get pregnant while using transdermal selegiline.
  • Inform the surgeon or dentist that you are using transdermal selegiline if you are undergoing surgery, including dental surgery.
  • You need to be aware that transdermal selegiline may cause you to feel sleepy. Prior to understanding how this drug affects you, avoid using machinery or driving a car.
  • Consult your doctor about whether drinking alcohol is safe while using transdermal selegiline.
  • You should be aware that if you stand up too rapidly from a laying position while using transdermal selegiline, you could experience dizziness, lightheadedness, and fainting. When you initially start using transdermal selegiline, this happens more frequently. Get out of bed gradually, resting your feet on the floor for a few minutes before standing up, to avoid this issue.

What special dietary instructions should I follow?

Throughout your transdermal selegiline treatment, you might need to adhere to a specific diet. This is based on how powerful the fixes you’re applying are. You can keep eating the same way as usual if you’re using the 6 mg/24-hour patch.

If you consume tyramine-rich meals while undergoing treatment for the 9 mg/24 hour patch or the 12 mg/24 hour patch, you risk having a severe reaction. Tyramine can be found in a variety of foods, including aged, smoked, inadequately stored, or rotten meat, poultry, fish, or cheese as well as some fruits, vegetables, beans, alcoholic beverages, and fermented yeast products. You’ll learn from your doctor or dietician which foods you must absolutely avoid and which ones you can consume in moderation. Pay close attention to these guidelines. If you have any inquiries regarding what you may eat and drink while undergoing treatment, speak with your doctor or nutritionist.

What should I do if I forget a dose?

Remove the old patch, apply a new one as soon as you recall, and carry on with your regular dosage schedule if you fail to change your patch after 24 hours. Don’t use an additional patch to make up for a forgotten dose.

What side effects can this medication cause?

Selegiline transdermal may have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • The color of the patched-up region is red
  • Diarrhea
  • Heartburn
  • Mouth ache
  • Slim down
  • Rash

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT WARNING section:

  • Terrible headache
  • Hammering, rapid, or irregular pulse
  • Chest ache
  • Neck pain or stiffness
  • Nausea
  • Vomiting
  • Sweating
  • Confusion
  • Widened pupils (black circles in the middle of the eyes)
  • Sensitivity to light in the eyes

Other negative effects from selegiline transdermal may occur. If you experience any strange issues while taking this medicine, contact your doctor right away.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. Do not remove a patch from its protective pouch until you are prepared to apply it. Store the patches in their pouches.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilizing a medicine take-back program is the easiest approach to get rid of your medication. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Drowsiness
  • Dizziness
  • Faintness
  • Irritability
  • Hyperactivity
  • Agitation
  • Terrible headache
  • Hallucinations (seeing or hearing things or sounds that are not there)
  • Jaw clenching
  • Rigidity, as well as back arching
  • Seizures
  • Coma (a temporary loss of consciousness)
  • Rapid and erratic heartbeat
  • Chest ache
  • Decreased breathing
  • Sweating
  • Fever
  • Cold, clammy skin

What other information should I know?

Keep all of your doctor’s appointments.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Emsam®
Copyright © 2023