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There is a higher risk of developing severe liver damage if you take eltrombopag along with hepatitis C medications such as interferon (Peginterferon, Pegintron, and others) and ribavirin (Copegus, Rebetol, Ribasphere, and others) and you have chronic hepatitis C (an ongoing viral infection that may damage the liver). Call your doctor right away if you have any of the following symptoms: the skin or eyes turning yellow, having dark urine, being overly exhausted, having discomfort in the upper right region of the stomach, having stomach enlargement, or being confused.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to eltrombopag, your doctor will prescribe a number of laboratory tests both before and during your therapy.

Each time you refill your prescription for eltrombopag, your doctor or pharmacist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

Eltrombopag dangers should be discussed with your doctor.

Why is this medication prescribed?

Eltrombopag is used to treat chronic immune thrombocytopenia (ITP), an ongoing condition that can result in unusual bruising or bleeding due to an abnormally low number of platelets in the blood, in adults and children 1 year of age and older who have not responded to other treatments or are unable to receive them, such as medication or spleen removal surgery, by increasing the number of platelets (cells that help the blood clot). Eltrombopag is also used to boost platelet counts in hepatitis C patients so they can start and complete therapy with interferon (Peginterferon, Pegintron, and other types) and ribavirin (Rebetol), a viral infection that may harm the liver. Eltrombopag is also used to treat aplastic anemia in adults and children 2 years of age and older. Aplastic anemia is a disorder in which the body does not produce enough new blood cells. Adults with aplastic anemia who have not responded to other drugs can also receive it for treatment. Eltrombopag is used to boost platelet counts sufficiently to lower bleeding risks in patients with ITP or aplastic anemia, or to enable interferon and ribavirin treatment in patients with hepatitis C. To bring the quantity of platelets to a normal level, however, it is not employed. People who have low platelet counts due to illnesses other than ITP, hepatitis C, or aplastic anemia shouldn’t be treated with eltrombopag. Eltrombopag belongs to the group of drugs known as thrombopoietin receptor agonists. It works by increasing the number of platelets made by bone marrow cells.

How should this medicine be used?

Both a tablet and a powder for oral suspension (liquid) are available for eltrombopag. On an empty stomach, at least one hour before or two hours after eating, it is typically taken once daily. Eltrombopag should be taken at roughly the same time each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Eltrombopag should be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Eltrombopag should be taken at least two hours prior to or four hours following the consumption of high-calcium meals and beverages, such as dairy goods, calcium-fortified juices, cereals, oats, and breads; fish; clams; leafy green vegetables like spinach and collard greens; tofu and other soy products. If you are unsure whether a food includes a lot of calcium, consult your doctor. To be able to eat these items throughout the majority of your awake hours, you might find it helpful to take eltrombopag near to the start or finish of your day.

Completely swallow the tablets. Avoid breaking, chewing, or crushing them before adding them to meals or liquids.

Read the manufacturer’s directions for use that are included with the medication carefully if you are taking the powder for oral suspension. How to prepare and measure your dose is explained in these directions. Before using, combine the powder with cool or cold water. Keep the powder and boiling water separate. Swallow the dose immediately after preparation. Do not dump the combination down the sink if it is not consumed within 30 minutes or if there is still liquid. Instead, discard it in the garbage.

Do not let the powder come in contact with your skin. If the powder accidentally gets on your skin, wash it off right away with soap and water. If you experience a skin response or have any concerns, call your doctor.

Eltrombopag will likely be prescribed to you at a low starting dose by your doctor, who will then adjust it based on how you react to the drug. Your doctor will prescribe a blood test to check your platelet count once a week when you first start treatment. If your platelet level is too low, your doctor could raise your dose. Your doctor might lower your dose or temporarily stop giving you eltrombopag if your platelet count is too high. Your platelet level will be monitored less frequently once your therapy has been going on for a while and your doctor has established the dosage of eltrombopag that is effective for you. After stopping eltrombopag, your platelet level will also be monitored every week for at least 4 weeks.

If you have chronic ITP, in addition to eltrombopag, you can also be prescribed other drugs to treat your illness. If eltrombopag is effective for you, your doctor may lower the dosage of these drugs.

Not everyone responds well to eltrombopag. Your doctor may advise you to stop taking eltrombopag if your platelet count does not rise sufficiently after taking it for a while.

Eltrombopag might help you manage your disease, but it won’t make it go away. Eltrombopag should be taken even if you feel fine. Without consulting your doctor, never stop taking eltrombopag.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking eltrombopag,

  • If you have an allergy to eltrombopag, any other medications, or any of the substances in eltrombopag tablets, inform your doctor right away. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about any vitamins, nutritional supplements, herbal items, and prescription and over-the-counter medicines you are now taking or intend to take. Any of the following should be mentioned: Bosentan (Tracleer), warfarin (Coumadin, Jantoven), and statins (anti-cholesterol drugs) like atorvastatin (Lipitor, in Caduet) are examples of anticoagulants (blood thinners), rosuvastatin (Crestor), fluvastatin (Lescol), pitavastatin (Livalo, Zypitamag), pravastatin (Pravachol), and simvastatin (Zocor, Flolopid, in Vytorin); irinotecan (Camptosar, Onivyde); ezetimibe (Zetia, in Vytorin); glyburide (Diabeta, Glynase); imatinib (Gleevec); olmesartan (Benicar, in Azor, in Tribenzor); lapatinib (Tykerb); mitoxantrone, repaglinide (Prandin), rifampin (Rimactane, Rifadin, in Rifamate, Rifater), sulfasalazine (Azulfidine), topotecan (Hycamtin), and valsartan (Diovan, in Byvalson, in Entresto, in Exforge) are examples of medications that contain methotrexate. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Eltrombopag may also interact with a variety of other drugs, so be sure to let your doctor know about all the drugs you are taking, even those not on this list.
  • Take eltrombopag 2 hours before or 4 hours after taking Maalox, Mylanta, or Tums or any antacids containing calcium, aluminum, or magnesium, as well as any vitamin or mineral supplements containing calcium, iron, zinc, or selenium.
  • Inform your doctor if you have or have ever had a blood clot, a cataract (clouding of the lens of the eye that may cause vision problems), bleeding issues, myelodysplastic syndrome (MDS), a blood disorder that can result in cancer, or liver disease, and if you are of East Asian (Chinese, Japanese, Taiwanese, or Korean) descent. Additionally, let your doctor know if you’ve had your spleen removed during surgery.
  • If you are pregnant or plan to become pregnant, inform your doctor right away. During your eltrombopag treatment, you shouldn’t get pregnant. While you are getting treatment and for seven days following your final dose, use an effective form of birth control. Call your doctor if you become pregnant while taking eltrombopag.
  • Describe to your doctor if you are nursing a baby. Eltrombopag should not be taken while nursing a baby.
  • Throughout your eltrombopag therapy, continue to refrain from any activity that could lead to bleeding or harm. Eltrombopag is used to lessen the possibility of serious bleeding, but bleeding is still a possibility.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Ignore the missed dose and carry on with my normal dosing routine. To make up for a missing dose, do not take a second one. Eltrombopag should only be used once each day.

What side effects can this medication cause?

Eltrombopag could have unwanted effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Back ache
  • Muscular pain or spasms
  • Headache
  • Flu-related symptoms such body pains, chills, fatigue, sore throat, and fever
  • Weakness
  • Extreme fatigue
  • Reduction in appetite
  • Intense discomfort or throat or mouth swelling
  • Hair fall
  • Rash
  • Skin tone varies
  • Tingling, stinging, or burning of the skin
  • Edema in the lower legs, foot, or ankles
  • Dental pain in young people

Some adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you develop any of these signs or any of the ones detailed in the IMPORTANT WARNING section:

  • One leg may experience edema, pain, stiffness, warmth, or redness.
  • Breathlessness, blood in the cough, a rapid heartbeat, rapid breathing, and pain with deep breathing
  • Cold sweats, pain in the chest, arms, back, neck, jaw, or stomach, and dizziness
  • Speech that is slurred or difficult, sudden numbness or weakness in the face, arm, or leg, a headache, or trouble seeing are all signs of unexpected difficulties walking.
  • Nausea, vomiting, diarrhea, and stomach pain
  • Vision that is clouded, hazy, or has other visual alterations

There may be more negative effects from eltrombopag. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. Keep the desiccant packet in the bottle if your medication came with one (a tiny packet containing an ingredient that absorbs moisture to keep the drug dry), but take cautious not to consume it.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilizing a medicine take-back program is the easiest approach to get rid of your medication. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Rash
  • Reduced heart rate
  • Extreme fatigue

What other information should I know?

Both before and after your eltrombopag treatment, your doctor will prescribe an eye exam.

Never allow someone else to take your medication. If you have any queries regarding getting a prescription renewed, ask your pharmacist.

You should keep a written record of every drug you take, including prescription and nonprescription (over-the-counter) medications, vitamins, minerals, and other dietary supplements. Every time you see a doctor or are admitted to the hospital, you should carry this list with you. Additionally, it is crucial to have this knowledge on hand in case of emergency.

Brand names

  • Promacta®
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