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Elotuzumab Injection

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Why is this medication prescribed?

Elotuzumab injection is used in conjunction with lenalidomide (Revlimid), dexamethasone, or pomalidomide (Pomalyst), as well as dexamethasone, to treat multiple myeloma, a type of bone marrow cancer, when other treatments have failed or when the condition has improved but later returned. The drug elotuzumab injection belongs to the monoclonal antibody drug class. It functions by assisting the body in reducing or halting the growth of cancer cells.

How should this medicine be used?

In a medical environment, a doctor or nurse will administer elotuzumab intravenously (into a vein) after mixing the powder with sterile water. It is typically administered once every week for the first two cycles (each cycle is a 28-day treatment period) when used in conjunction with lenalidomide and dexamethasone, and once every two weeks after that. It is often administered once weekly for the first two cycles (each cycle is a 28-day treatment period) when combined with pomalidomide and dexamethasone, and then once every four weeks after that.

In order to ensure that you are not having a severe reaction to the medication, a doctor or nurse will keep a close eye on you both during and after the infusion. To assist stop elotuzumab responses, other drugs will be administered to you. If any of the following symptoms liked fever, chills, rash, dizziness, lightheadedness, slowed heartbeat, chest pain, difficulty breathing, or shortness of breath, occur during the infusion or for up to 24 hours after you get it, let your doctor or nurse know right away.

Your doctor may lower your elotuzumab dosage or temporarily or permanently cease your treatment. The effectiveness of the drug and any negative side effects you encounter will determine this. As you receive elotuzumab treatment, be sure to discuss your feelings with your doctor.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving elotuzumab injection,

  • If you have an allergy to elotuzumab, any other medications, or any of the chemicals in elotuzumab injection, let your doctor and chemist know right once. For a list of the chemicals, consult your chemist or the manufacturer’s patient information.
  • Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have an infection or have ever had liver illness, let your doctor know.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you get pregnant while receiving an injection of elotuzumab.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

The injection of elotuzumab may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Diarrhea
  • Constipation
  • Headache
  • Vomiting
  • Mood shifts
  • Slim down
  • Morning sweats
  • Reduced or numbed sensation of touch
  • Bone ache
  • Muscles cramping
  • Your arms or legs swelling

Some adverse effects can be very harmful. Call your doctor right away if you suffer any of these symptoms or those detailed in the HOW section:

  • Shortness of breath, chills, a sore throat, a fever, or a cough; discomfort or burning when urinating; a severe rash; or other indicators of infection
  • Your arms or legs feeling numb, weak, tingly, or in pain
  • Chest ache
  • Nausea, severe fatigue, a lack of energy, appetite loss, yellowing of the skin or eyes, dark urine, pale faeces, confusion, and pain in the upper right side of the stomach are some of the symptoms that may be present
  • Vision alterations

Your chance of developing some malignancies may increase if you receive an injection of elotuzumab. You should discuss the dangers of using this drug with your doctor.

Other negative effects from elotuzumab injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor how your body reacts to the elotuzumab injection, your doctor will request a few lab tests.

Inform the lab staff and your doctor that you are receiving an elotuzumab injection prior to any laboratory test.

Ask your pharmacist any inquiries you may have regarding the injection of elotuzumab.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Empliciti®
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