WARNING

Elitek (rasburicase) is a medication used to prevent high levels of uric acid in the blood, which can occur as a result of chemotherapy treatment for certain types of cancer. While Elitek can be effective in reducing uric acid levels, there are potential risks associated with its use:

• Allergic reactions: Some individuals may experience allergic reactions to Elitek, which can range from mild to severe. Symptoms may include rash, itching, swelling, difficulty breathing, or anaphylaxis.
• Hemolysis: Elitek can cause the breakdown of red blood cells, a condition known as hemolysis. This can lead to anemia (low red blood cell count), jaundice (yellowing of the skin and eyes), and other complications.
• Methemoglobinemia: Elitek may cause an increase in methemoglobin levels in the blood, which can reduce the blood’s ability to carry oxygen to tissues and organs. This can lead to symptoms such as shortness of breath, headache, dizziness, and fatigue.
• Gout flares: In some cases, Elitek may trigger gout flares, particularly in individuals with a history of gout or elevated uric acid levels.
• Renal impairment: Elitek can cause kidney damage or worsen existing kidney problems. Patients with pre-existing kidney disease or those at risk for kidney impairment should be monitored closely while taking Elitek.

It’s important for patients to discuss the potential risks and benefits of Elitek with their healthcare provider before starting treatment. Healthcare providers should closely monitor patients receiving Elitek for any signs of adverse reactions and adjust treatment as necessary.

Why is this medication prescribed?

Elitek (rasburicase) is prescribed primarily to prevent and treat high levels of uric acid in the blood, a condition known as hyperuricemia. This elevation in uric acid levels can occur as a result of chemotherapy treatment for certain types of cancer, such as leukemia, lymphoma, or solid tumor malignancies. When cancer cells break down rapidly during chemotherapy, they release large amounts of uric acid into the bloodstream, which can lead to serious complications such as kidney damage, kidney stones, or gout.

Elitek works by rapidly converting uric acid into a more soluble form called allantoin, which is then easily excreted from the body through urine, preventing the buildup of uric acid in the blood.

How should this medicine be used?

How Elitek should be used:

• Administration: Elitek is typically administered intravenously (IV) by a healthcare professional in a clinical setting such as a hospital or infusion center.
• Dosage: The dosage of Elitek depends on factors such as the patient’s weight, kidney function, and the specific chemotherapy regimen being used. It is important to follow the dosage instructions provided by the healthcare provider.
• Timing: Elitek is usually given once daily for up to 5 days, starting either before or on the first day of chemotherapy treatment.
• Hydration: Patients receiving Elitek may be advised to drink plenty of fluids to help flush out the uric acid from their system and prevent kidney damage.
• Monitoring: Patients undergoing treatment with Elitek should be closely monitored for signs of allergic reactions, hemolysis, methemoglobinemia, or other adverse effects. Blood tests may be performed to monitor uric acid levels and kidney function during treatment.

It’s important for patients to discuss any questions or concerns about Elitek with their healthcare provider before starting treatment.

Other uses for this medicine

While Elitek is primarily indicated for managing hyperuricemia associated with TLS in cancer patients, it may also have other potential uses or applications:

• Off-label Use: In some cases, Elitek may be used off-label for conditions associated with hyperuricemia, such as gout or certain metabolic disorders.
• Investigational Use: Ongoing research may explore potential uses of rasburicase in other conditions where reducing uric acid levels is beneficial.

What special precautions should I follow?

Special precautions should be taken when using Elitek, and it’s essential to follow the guidance of your healthcare provider closely. Here are some specific precautions to consider:

• Allergy: Inform your healthcare provider if you have a history of allergies, particularly to rasburicase or other medications. Allergic reactions to Elitek can be severe and may require immediate medical attention.
• G6PD deficiency: Elitek can cause hemolysis, a condition where red blood cells are destroyed, particularly in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Inform your healthcare provider if you have this condition, as special precautions may be necessary.
• Methemoglobinemia: Elitek can cause an increase in methemoglobin levels in the blood, which can impair oxygen delivery to tissues. Patients with pre-existing methemoglobinemia or conditions that increase the risk of methemoglobinemia should be closely monitored during treatment.
• Renal impairment: Elitek can cause kidney damage or worsen existing kidney problems. Patients with pre-existing kidney disease or those at risk for kidney impairment should be closely monitored while taking Elitek, and dosage adjustments may be necessary.
• Other medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Elitek and affect its effectiveness or increase the risk of side effects.

It’s essential to discuss any questions or concerns about Elitek and its potential risks and benefits with your healthcare provider before starting treatment.

What special dietary instructions should I follow?

Regarding special dietary instructions for Elitek, there are no specific dietary restrictions associated with its use. However, it’s essential to stay well-hydrated during treatment with Elitek to help flush out uric acid from the body. Your healthcare provider may recommend increasing fluid intake or following a balanced diet to support overall health and hydration.

What should I do if I forget a dose?

If you forget a dose of Elitek, it’s important to contact your healthcare provider or infusion center as soon as possible for guidance. Depending on the circumstances, your healthcare provider may recommend rescheduling the missed dose or adjusting your treatment plan accordingly. It’s crucial not to try to make up for a missed dose by taking extra medication unless instructed to do so by your healthcare provider.

What side effects can this medication cause?

Elitek (rasburicase) can cause side effects, although not everyone will experience them. Common side effects of Elitek may include:

• Allergic reactions: Some individuals may experience allergic reactions to Elitek, which can range from mild symptoms such as rash or itching to more severe reactions including swelling, difficulty breathing, or anaphylaxis.
• Hemolysis: Elitek can cause the breakdown of red blood cells, leading to anemia (low red blood cell count), jaundice (yellowing of the skin and eyes), and other complications associated with hemolytic anemia.
• Methemoglobinemia: Elitek may cause an increase in methemoglobin levels in the blood, which can reduce the blood’s ability to carry oxygen to tissues and organs. Symptoms of methemoglobinemia may include shortness of breath, headache, dizziness, and fatigue.
• Gout flares: In some cases, Elitek may trigger gout flares, particularly in individuals with a history of gout or elevated uric acid levels.
• Renal impairment: Elitek can cause kidney damage or worsen existing kidney problems. Symptoms of kidney impairment may include changes in urine output, swelling, fatigue, or confusion.
• Other side effects: Other less common side effects of Elitek may include nausea, vomiting, abdominal pain, fever, chills, or injection site reactions.

It’s important to inform your healthcare provider if you experience any side effects while receiving Elitek. Your healthcare provider can provide guidance on managing side effects and may adjust your treatment plan if necessary. Additionally, seek medical attention immediately if you experience severe allergic reactions or symptoms of serious side effects such as difficulty breathing, chest pain, or severe abdominal pain.

What should I know about storage and disposal of this medication?

Storage and disposal of Elitek:

• Storage: Elitek should be stored in its original packaging at room temperature, away from moisture, heat, and light. Do not freeze Elitek. Follow the storage instructions provided by your healthcare provider or pharmacist.
• Disposal: Dispose of any unused Elitek solution properly according to local regulations or guidelines. Do not flush Elitek down the toilet or pour it down the drain unless instructed to do so. Consult with your pharmacist or healthcare provider on the proper disposal method.

In case of emergency/overdose

• If you suspect an overdose or experience severe side effects after receiving Elitek, seek emergency medical attention or contact your local poison control center immediately.
• Be prepared to provide information such as the amount of Elitek received, the time of administration, and any symptoms experienced.
• If possible, bring the Elitek packaging or container with you to the emergency room to assist healthcare providers in providing appropriate treatment.

What other information should I know?

• Keep all appointments for follow-up visits with your healthcare provider while receiving Elitek to monitor your progress and response to treatment.
• Inform all healthcare providers involved in your care, including dentists and pharmacists, that you are receiving Elitek. This will help prevent any potential interactions with other medications or treatments.
• It’s essential to stay well-hydrated during treatment with Elitek to help flush out uric acid from the body. Drink plenty of fluids unless otherwise instructed by your healthcare provider.
• Do not change the dosage or stop taking Elitek without consulting your healthcare provider, even if you start to feel better. Stopping treatment prematurely may allow uric acid levels to rise again, increasing the risk of complications.
• If you have any questions or concerns about Elitek or its use, do not hesitate to discuss them with your healthcare provider or pharmacist for clarification and guidance.