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Eligard (Generic Leuprolide Injection)

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Why is this medication prescribed?

Advanced prostate cancer symptoms are treated with leuprolide injection (Eligard, Lupron Depot). Central precocious puberty (CPP) is a condition that causes girls and boys to enter puberty too early, resulting in faster than normal bone growth and the development of sexual characteristics. Children 2 years of age and older can receive leuprolide injection (Lupron Depot-PED, Fensolvi) to treat CPP. Endometriosis is a disorder in which the tissue that lines the uterus (womb) grows in other parts of the body and causes discomfort, heavy or irregular menstruation [periods], and other symptoms. Leuprolide injection (Lupron Depot), a drug taken alone or in combination with norethindrone, is used to treat endometriosis. Uterine fibroids, which are benign growths of the uterus, can also induce anaemia, which is treated with leuprolide injection (Lupron Depot) in combination with other medications. Leuprolide injection belongs to a group of drugs known as GnRH (gonadotropin-releasing hormone) agonists. It functions by lowering the body’s levels of specific hormones.

How should this medicine be used?

A physician or nurse will typically administer leuprolide injection intramuscularly (into a muscle) once a month (Lupron Depot, Lupron Depot-PED), or every 3, 4, or 6 months (Lupron Depot-3 month, Lupron Depot-PED-3 month, Lupron Depot-4 month, Lupron Depot-6 Month). Leuprolide injection is available as a long-acting suspension (Lupron). Leuprolide injection is also available as a long-acting suspension (Eligard), which is administered by a physician or nurse in a hospital or clinic on a regular basis (every 1, 3, or 6 months). The injection of leuprolide is also available as a long-acting suspension (Fensolvi), which is administered by a physician or nurse in a hospital or clinic subcutaneously (just under the skin) and typically once every six months. How long your leuprolide injectable treatment will last will be determined by your doctor. Your child’s doctor will probably discontinue leuprolide injection (Lupron Depot-PED, Lupron Depot-PED-3 month, Fensolvi) before the age of 11 for girls and the age of 12 for boys when used in children with precocious puberty.

When you initially get leuprolide long-acting suspension (Eligard) by subcutaneous injection, you can experience a little bump where the injection was administered. This hump ought go disappear gradually.

In the first few weeks following injection, leuprolide may boost levels of several hormones. Throughout this period, your doctor will keep a close eye on you for any new or worsening symptoms.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving leuprolide injection,

  • If you have an allergy to leuprolide, goserelin (Zoladex), histrelin (Supprelin LA, Vantas), nafarelin (Synarel), triptorelin (Triptodur, Trelstar), any other medications, or any of the chemicals in leuprolide injection, let your doctor and chemist know right away. Request an ingredient list from your chemist.
  • Inform your doctor and chemist about any additional prescription and over-the-counter medications, vitamins, herbal items, nutritional supplements, and other drugs you are now taking or intend to take. Any of the following should be mentioned: such as amiodarone (Cordarone), disopyramide (Norpace), procainamide (Procanbid), quinidine, and sotalol (Betapace, Betapace AF, Sorine); oral steroids like dexamethasone (Hemady), methylprednisolone (Medrol), and prednisone (Rayos); medicines for seizures; buproprion (Aplenzin, Forfivo, Wellbutrin, and Contrave); fluoxetine (Prozac, Sarafem, in Symbyax), citalopram (Celexa), escitalopram (Lexapro), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil), and sertraline (Zoloft) are examples of selective serotonin reuptake inhibitors (SSRIs). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Leuprolide may interact with a wide range of other drugs, so be sure to let your doctor know about everything you’re taking even anything not on this list.
  • If you experience unusual vaginal bleeding, let your doctor know. Leuprolide injection may not be used, according to your doctor.
  • Inform your doctor if you or any family members have ever experienced osteoporosis (a condition in which the bones are brittle and more prone to breaking); if you’ve previously used tobacco or alcohol over an extended period of time; or if you now have or have ever had diabetes, brain tumours, seizures, cancer of the spine, brain tumours, or urinary obstruction (a blockage that makes it difficult to urinate), blood in the urine, a protracted QT interval, cerebrovascular disease, heart disease, low potassium, calcium, or magnesium levels in the blood, which is a rare heart condition that can result in irregular heartbeat, fainting, or sudden death.
  • You should be aware that leuprolide should not be used by women who are nursing or who are pregnant or who may become pregnant. Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. When you start receiving leuprolide injection, your doctor may run a pregnancy test to make sure you are not pregnant. To avoid getting pregnant while using leuprolide injection, you must utilise an effective nonhormonal birth control method. Even if you shouldn’t experience regular menstrual cycles while receiving treatment, discuss the best birth control methods with your doctor and keep using it. Call your doctor right away if you suspect that you become pregnant while having leuprolide injection. The foetus may suffer from leuprolide injection.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

You should contact your doctor as soon as possible to reschedule your visit if you need to have a leuprolide injection.

What side effects can this medication cause?

The injection of leuprolide may have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Tiredness
  • Sweating, clamminess, or hot flashes (a sudden surge of mild to extreme body heat)
  • Breast sensitivity, discomfort, or enlargement in both men and women
  • Women’s vaginal discharge, dryness, or itching
  • Light vaginal bleeding, often known as spotting, or periods
  • Testicular size reduction
  • Decline in sexual prowess or inclination
  • Hands, feet, ankles, or lower legs swelling
  • Hands or feet with ache, burning, or tingling
  • At the site of the injection, there may be discomfort, burning, bruising, redness, or hardness
  • Weight fluctuation
  • Joint or muscle discomfort
  • The flu-like symptoms of a runny nose, cough, sore throat, or both
  • Fever
  • Abdominal pain
  • Constipation
  • Headache
  • Acne
  • Depression
  • Lack of emotional control and frequent mood swings
  • Nervousness
  • Broad sense of unease or discomfort
  • Problem with memory

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Hives, rash, or itching
  • Breathing or swallowing challenges
  • Arm, back, chest, neck, or jaw discomfort
  • Slow or challenging speech
  • Nausea or fainting
  • Lack of strength, numbness, or immobility in an arm or leg
  • Bone ache
  • Unpleasant, frequent, or challenging urinating
  • Urinary blood
  • Severe thirst
  • Weakness
  • Mouth ache
  • Nausea
  • Vomiting
  • Fruity-smelling breath
  • Diminished awareness
  • Abrupt headache
  • Fuzzy vision
  • Vision alterations
  • Eyes have difficulty moving
  • Slack eyelids
  • Confusion
  • Seizures

Your bone density may decrease as a result of receiving leuprolide injections, increasing your risk of breaking a bone. Consult your doctor to learn more about the dangers associated with taking this drug and what you may do to reduce them.

During the first few weeks of treatment, children getting leuprolide injection (Lupron Depot-PED, Fensolvi) for precocious puberty may have new or worsened signs of sexual development. Menstruation or spotting (light vaginal bleeding) may start in girls getting leuprolide injection (Lupron Depot-PED) for precocious puberty during the first two months of treatment. Call your doctor if bleeding lasts through the second month.

Other negative effects from leuprolide injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online at or by phone at 1-800-332-1088 if you suffer a serious side event.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. In order to monitor your body’s reaction to the leuprolide injection, your doctor will conduct specific lab tests and take specific measures. Regular blood tests for your blood sugar and HbA1c (glycosylated haemoglobin) may also be performed.

Any queries you may have regarding the injection of leuprolide, ask your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Eligard®
  • Fensolvi®
  • Lupron®
  • Lupron Depot®
  • Lupron Depot-PED®
  • Lupaneta Pack® (as a combination product containing Leurprolide, Norethindrone)
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