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Egrifta (Generic Tesamorelin Injection)

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Why is this medication prescribed?

Adults with human immunodeficiency virus (HIV) who have lipodystrophy (increased body fat in specific parts of the body) can use tesamorelin injection to reduce the amount of additional fat in the stomach region. The injection of tesamorelin is not utilised to aid in weight loss. A group of drugs known as human growth hormone-releasing factor (GRF) analogues includes tesamorelin injection. It functions by boosting the synthesis of a particular natural compound that can reduce body fat.

How should this medicine be used?

Tesamorelin injection is available as a powder that must be dissolved in the medication’s accompanying liquid before being administered subcutaneously (under the skin). Typically, it is injected once each day. Use tesamorelin injection every day at roughly the same time. Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. As prescribed, administer the tesamorelin injection. Use it only as directed by your doctor, neither more nor less often.

Read the manufacturer’s information for the patient included with the drug before using tesamorelin injection for the first time. Your medication is packaged in two boxes: one contains injection vials of tesamorelin, and the other includes vials of liquid to mix with the drug, needles, and syringes. You should ask your doctor or chemist to demonstrate how to mix and inject the drug. If you have any concerns regarding how to inject this drug, be sure to consult your doctor or chemist.

Tesamorelin should be injected beneath the navel (belly button) into the skin of the abdomen. Tesamorelin should not be injected into the navel or any other areas of skin that are scarred, reddish, inflamed, infected, or bruised. Tesamorelin should not be injected into any locations that have hard bumps from prior injections. To lessen bruising and irritation, pick a different spot for each injection. Tesamorelin should not be injected again into the same region, therefore keep track of where you administer it.

Tesamorelin injection should be used immediately after mixing. After mixing, do not store tesamorelin injection. Get rid of any tesamorelin injections that have been used as well as any leftover liquid.

Before injecting, always check the tesamorelin injection solution (liquid) after mixing. The remedy must be free of particulates, transparent, and colourless. Tesamorelin injectable solution should not be used if it is coloured, hazy, contains particles, or has passed its expiration date.

Never share needles with another person and never reuse syringes or needles. Even if the needle has been changed, avoid sharing syringes. Sharing syringes and needles can lead to the spread of infections like HIV. Tell the person who was accidentally pricked by a used needle to contact his doctor immediately away. Put any unused tesamorelin injection, additional liquid used to prepare the injection, spent needles, and syringes in a container made of durable plastic or metal that can withstand punctures and has a lid. Never dispose of discarded syringes or needles in the trash. To dispose of the puncture-resistant container and any other discarded materials, consult your doctor or chemist.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using tesamorelin injection,

  • If you have any allergies, including to mannitol (Osmitrol), any medicines, or any of the chemicals in tesamorelin injection, notify your doctor right away. Request a list of the ingredients from your chemist.
  • Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: Corticosteroids or hormonal steroids like cortisone, dexamethasone (Decadron, Dexone), oestrogen (Premarin, Prempro, others), methylprednisolone (Medrol), prednisone (Deltasone), progesterone (Prometrium), and testosterone (Androderm, Androgel, others) are also used to treat seizures. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you are currently experiencing, or have ever experienced, pituitary gland surgery, a pituitary tumour, or any other pituitary gland-related issues. Additionally, let your doctor know if you currently have cancer, a growth, or a tumour. Tesamorelin injection may not be used, according to your doctor.
  • Inform your doctor if you have diabetes, renal disease, or liver illness now or in the past.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor right away if you get pregnant while taking tesamorelin injectable. The foetus could be harmed by tesamorelin. If you have HIV or are using tesamorelin injection, you shouldn’t breastfeed.
  • Inform the surgeon or dentist that you are using tesamorelin injection if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, administer it as soon as you remember. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not provide a second injection.

What side effects can this medication cause?

Tesamorelin injectable adverse effects are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Edoema of the lower legs, ankles, feet, or hands
  • Hands or wrists that hurt or are numb
  • Feeling of tingling, numbness, or prickling
  • At the injection site, look for redness, itching, discomfort, bruising, bleeding, or swelling
  • Itching
  • Joints hurt
  • Ache in the legs or arms
  • Muscle stiffness, pains, or spasms
  • Vomiting
  • Morning sweats
  • Having trouble falling or staying asleep

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Rash
  • Hives
  • Swelling of the throat or face
  • Breathing difficulty
  • Having trouble breathing
  • Dizziness
  • Fainting

Other negative consequences from tesamorelin injection are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online at or by phone at 1-800-332-1088 if you suffer a serious side event.

What should I know about storage and disposal of this medication?

The tesamorelin injection vials and pharmaceutical package should be kept in the fridge. Avoid freezing. Away from light, excessive heat, and moisture (not in the bathroom), keep the package containing the given liquid, needles, and syringes at room temperature. Each box should be securely secured and out of children’s reach.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the ideal approach to get rid of your medicines. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling department in your city. If you do not have access to a take-back programme, visit the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the tesamorelin injection, your doctor will request specific lab tests both before and after your therapy.

Do not share your medication with anybody else. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Egrifta®
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