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Edurant (Generic Rilpivirine)

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Why is this medication prescribed?

Edurant is a brand name for the medication Rilpivirine, which is an antiretroviral medication used in the treatment of HIV-1 infection. It belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Here’s why Edurant (Rilpivirine) is prescribed:

  • HIV-1 Infection: It is used in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 35 kg (77 lbs).
  • Suppressing HIV Replication: Edurant works by inhibiting the reverse transcriptase enzyme, thus interfering with the replication of HIV within the body. This helps to reduce the viral load, improve the immune system, and slow down the progression of HIV-related illnesses.

How should this medicine be used?

As for how Edurant should be used:

  • Dosage: The recommended dosage of Edurant is usually one tablet (25 mg) taken orally once daily with a meal.
  • Compliance: It’s important to take Edurant regularly and exactly as prescribed by your healthcare provider. Missing doses or not taking it consistently can lead to the development of drug resistance and reduce its effectiveness.
  • Food Intake: Edurant should be taken with a meal. This helps increase the absorption of the medication into the bloodstream and improves its effectiveness.
  • Interaction with Antacids or Acid-Reducing Agents: It’s important to avoid taking Edurant with certain antacids or acid-reducing agents, as they can decrease the absorption of the medication. If you need to take these medications, consult your healthcare provider for guidance on timing.
  • Consultation: Always consult your healthcare provider or pharmacist if you have any questions or concerns about how to take Edurant properly.

Remember, while Edurant is an effective medication for managing HIV-1 infection, it’s just one part of a comprehensive treatment plan. It’s crucial to follow your healthcare provider’s instructions, take all prescribed medications consistently, and attend regular check-ups to monitor your HIV status and overall health.

Other uses for this medicine

Edurant (Rilpivirine) is primarily used for the treatment of HIV-1 infection, as mentioned earlier. However, there aren’t any other widely accepted medical uses for Edurant outside of its antiretroviral effects in managing HIV-1.

What special precautions should I follow?

As for special precautions to follow when taking Edurant:

  • HIV Testing and Monitoring: Before starting Edurant or any antiretroviral therapy, it’s essential to confirm the diagnosis of HIV infection through appropriate testing. Additionally, regular monitoring of HIV viral load, CD4 cell count, and other laboratory parameters is necessary to assess treatment effectiveness and disease progression.
  • Drug Interactions: Edurant can interact with other medications, including over-the-counter drugs, supplements, and herbal products. Some drugs may decrease the effectiveness of Edurant, while others can increase the risk of adverse effects. Inform your healthcare provider about all the medications and supplements you are taking to avoid potential interactions.
  • Liver Function: Edurant can affect liver function. Your healthcare provider may perform liver function tests before initiating treatment and periodically during therapy to monitor for any signs of liver damage or dysfunction.
  • Pregnancy and Breastfeeding: If you are pregnant or planning to become pregnant, or if you are breastfeeding, discuss the risks and benefits of Edurant with your healthcare provider. It’s essential to weigh the potential benefits of treatment for the mother against the potential risks to the fetus or infant.
  • Central Nervous System Effects: Some individuals may experience central nervous system side effects such as dizziness, insomnia, abnormal dreams, and difficulty concentrating while taking Edurant. If you experience these symptoms, discuss them with your healthcare provider.
  • Resistance: Like other antiretroviral medications, resistance to Edurant can develop if it is not taken consistently as prescribed. It’s crucial to take Edurant exactly as directed to maintain its effectiveness in controlling HIV infection.
  • Allergic Reactions: Seek immediate medical attention if you experience signs of an allergic reaction to Edurant, such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

Always follow your healthcare provider’s instructions and guidance regarding the use of Edurant, and do not hesitate to ask questions or seek clarification about any concerns you may have regarding its use and potential side effects.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with taking Edurant. However, it’s recommended to take Edurant with a meal to enhance absorption. Avoid taking Edurant with certain antacids or acid-reducing agents, as they may decrease its absorption.

What should I do if I forget a dose?

If you miss a dose of Edurant, take it as soon as you remember, but only if it is within 12 hours of your usual dosing time. If more than 12 hours have passed since your missed dose, skip the missed dose and take your next dose at the regular time. Do not take a double dose to make up for a missed one. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance. It’s important to maintain a consistent dosing schedule to ensure the effectiveness of Edurant in controlling HIV infection.

What side effects can this medication cause?

Edurant (Rilpivirine) can cause side effects, although not everyone will experience them. Some common side effects of Edurant include:

  • Dizziness: Feeling lightheaded or dizzy is a common side effect of Edurant. It may occur especially when standing up quickly from a sitting or lying position.
  • Headache: Headaches are another common side effect that some individuals may experience while taking Edurant.
  • Insomnia: Difficulty falling asleep or staying asleep (insomnia) can occur in some people taking Edurant.
  • Abnormal Dreams: Some individuals may experience vivid or abnormal dreams while taking Edurant.
  • Nausea: Nausea, or feeling like you may vomit, can occur as a side effect of Edurant.
  • Rash: Skin rash is a possible side effect of Edurant. If you develop a rash while taking Edurant, contact your healthcare provider.
  • Depression: Some people may experience symptoms of depression while taking Edurant. It’s essential to discuss any mood changes or symptoms of depression with your healthcare provider.
  • Liver Problems: Edurant can affect liver function, and in some cases, it may cause liver problems. Signs of liver problems include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or unusual fatigue. Contact your healthcare provider immediately if you experience any of these symptoms.
  • Allergic Reactions: Serious allergic reactions to Edurant are rare but possible. Seek immediate medical attention if you experience symptoms such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

It’s important to note that this list may not include all possible side effects of Edurant. Some individuals may experience other side effects not listed here. If you experience any new or worsening symptoms while taking Edurant, contact your healthcare provider for further evaluation and guidance.

What should I know about storage and disposal of this medication?

Storage and Disposal of Edurant:


  • Keep Edurant tablets in their original packaging and store them at room temperature, away from moisture and heat.
  • Do not store Edurant in the bathroom or kitchen where it could be exposed to moisture or humidity.
  • Keep Edurant out of reach of children and pets.
  • Store Edurant away from direct sunlight and extreme temperatures.
  • Do not use Edurant if the packaging is damaged or if the tablets appear discolored or show signs of deterioration.


  • Dispose of any unused or expired Edurant tablets properly according to local regulations or guidelines.
  • Do not flush Edurant tablets down the toilet or pour them down the drain unless instructed to do so by local waste disposal authorities.
  • Consult your healthcare provider or pharmacist for guidance on the proper disposal of Edurant tablets.

In case of emergency/overdose

  • If you suspect an overdose of Edurant or experience severe symptoms such as severe dizziness, fainting, difficulty breathing, or loss of consciousness, seek immediate medical attention or call your local emergency services.
  • If possible, have the packaging or container of Edurant with you to provide information about the medication to healthcare professionals.

What other information should I know?

  • Always take Edurant exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting your healthcare provider first.
  • Inform all healthcare providers involved in your care about all medications, supplements, and herbal products you are taking, including Edurant, to prevent potential drug interactions.
  • Attend all scheduled appointments with your healthcare provider for monitoring of your HIV infection and response to treatment.
  • If you have any questions or concerns about Edurant or its use, do not hesitate to discuss them with your healthcare provider or pharmacist for clarification and guidance.
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