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Edoxaban

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WARNING

If you are taking edoxaban to help prevent strokes or serious blood clots and have atrial fibrillation (a condition in which the heart beats erratically, increasing the risk of clots forming in the body and potentially causing strokes), you are at an increased risk of having a stroke once you stop taking the drug. Without first seeing your doctor, do not discontinue taking edoxaban. Edoxaban should still be taken even if you feel OK. To avoid missing any edoxaban doses, make sure to replenish your prescription before you run out of medicine. To assist prevent a blood clot from developing and leading to a stroke, your doctor may prescribe another anticoagulant (also known as a “blood thinner”), if you need to stop taking edoxaban.

You run the risk of developing a blood clot in or near your spine if you receive epidural or spinal anaesthesia, or if you undergo a spinal puncture while taking a “blood thinner” like edoxaban. Inform your doctor if you have an epidural catheter still inside your body, have undergone spinal surgery, have had several epidural or puncture wounds, or if you have spinal deformities. Inform your doctor and chemist if you are using aspirin, anagrelide (Agrylin), ibuprofen (Advil, Motrin, and others), indomethacin (Indocin, Tivorbex), ketoprofen, or naproxen (Aleve, Anaprox, and others); heparin, cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine), eptifibatide (Integrilin), ticagrelor (Brilinta), ticlopidine, tirofiban (Aggrastat), and warfarin (Coumadin, Jantoven). Call your doctor right away if you suffer any of the following symptoms: back pain, muscle weakness, numbness or tingling (particularly in your legs), loss of control of your bowels or bladder, or inability to move your legs.

Keep all of your appointments with your physician and the lab. Before starting and at regular intervals throughout your edoxaban medication, your doctor will conduct a test to determine how well your kidneys are functioning.

Each time you refill your prescription for edoxaban, your doctor or chemist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the information and ask your doctor or chemist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

The risk of using edoxaban should be discussed with your doctor.

Why is this medication prescribed?

Edoxaban is used to treat people with atrial fibrillation (a condition in which the heart beats erratically, raising the risk of clots forming in the body and potentially causing strokes) who are not suffering from heart valve disease prevent strokes or blood clots. In patients who have been receiving treatment with an injectable blood thinner for 5 to 10 days, edoxaban is also used to prevent deep vein thrombosis (DVT; a blood clot, typically in the leg) and pulmonary embolism (PE). Edoxaban belongs to the group of drugs known as factor Xa inhibitors. It functions by preventing the action of a certain natural chemical that promotes the formation of blood clots.

How should this medicine be used?

Edoxaban is available as an oral tablet. It is typically taken once day, with or without food. Edoxaban should be taken every day at roughly the same time. Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Edoxaban should be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

The tablets should be crushed and combined with 2 to 3 ounces (60 to 90 mL) of water or applesauce if you are unable to take them whole. Take the concoction right away.

The tablets can be broken up, combined with water, and administered through a stomach tube if you have one. You should take the medication as directed by your doctor or chemist. Take care to adhere to those instructions.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking edoxaban,

  • If you have an allergy to edoxaban, any other medications, or any of the chemicals in edoxaban pills, let your doctor and chemist know right once. For a list of the ingredients, consult the Medication Guide or speak with your chemist.
  • Inform your doctor and chemist about any additional prescription and non-prescription drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention the medications listed in the IMPORTANT WARNING section as well as any of the following: atorvastatin (Lipitor, in Caduet, in Liptruzet), amiodarone (Cordarone, Pacerone), dronedarone (Multaq), erythromycin (E.E.S., E-Mycin, Erythrocin), digoxin (Lanoxin), cyclosporine (Gengraf, Neoral), Quinidine, rifampin (Rifadin, in Rifamate, in Rifater, Rimactane), esomeprazole (Nexium, in Vimovo), ketoconazole (Nizoral), selective serotonin-reuptake inhibitors including citalopram (Celexa), escitalopram (Lexapro), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), fluoxetine (Prozac, Sarafem, Selfemra), and sertraline (Zoloft); SNRIs, or serotonin-norepinephrine reuptake inhibitors, include duloxetine (Cymbalta), desvenlafaxine (Khedezla), effexor, milnacipran (Savella), levomilnacipran (Fetzima), and verapamil (Calan, Covera, Isoptin, Verelan, in Tarka). Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects. It’s important to inform your doctor about all of the medications you are taking, including any that do not appear on this list, as many other drugs may also interact with edoxaban.
  • If you experience persistently excessive bleeding elsewhere in your body, let your doctor know. Most likely, your doctor will advise against taking edoxaban.
  • If you weigh less than 132 pounds (60 kilogrammes), have a mechanical heart valve, antiphospholipid syndrome (an autoimmune disorder that produces blood clots), stomach or intestine cancer, heart, kidney, or liver problems, or if you have any of these conditions, let your doctor know.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking edoxaban.
  • Inform the surgeon or dentist that you are taking edoxaban if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

On the same day, take the missed dose as soon as you remember. If it is the following day, skip the missing dose and carry on with your normal dosing regimen. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Edoxaban could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Rash
  • Unexpected fatigue or weakened state
  • Dizziness
  • Pale skin

Some adverse effects can be very harmful. Call your doctor right away if you have any of the following symptoms or any of those mentioned in the IMPORTANT WARNING section while taking edoxaban:

  • Bluish gums
  • Nosebleeds
  • Significant vaginal bleeding
  • Urine that is brown, pink, or red
  • Tarry, crimson or black stools
  • Vomiting or coughing up blood or what seems to be coffee grounds

Other negative effects of edoxaban are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088 if you suffer a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the ideal approach to get rid of your medicines. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling department in your city. If you do not have access to a take-back programme, visit the FDA’s Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.http://www.upandaway.org

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Uncommon bruising or bleeding
  • Tarry, dark, or bloody stools
  • Urinary blood
  • Vomiting or coughing up blood or what seems to be coffee grounds

What other information should I know?

Inform the lab staff and your doctor that you are taking edoxaban prior to any laboratory test.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Savaysa®
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