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Dutoprol (Generic Hydrochlorothiazide)

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Why is this medication prescribed?

Hydrochlorothiazide is a medication commonly prescribed to treat high blood pressure (hypertension) and edema (fluid retention) associated with various conditions like congestive heart failure, kidney disorders, and liver cirrhosis. It belongs to a class of drugs called diuretics, which work by increasing urine production, thereby reducing excess fluid and lowering blood pressure.

How should this medicine be used?

Here’s how Hydrochlorothiazide is typically used:

  • Dosage: The dosage of Hydrochlorothiazide varies depending on the condition being treated and individual patient response. It’s usually taken orally in the form of tablets or capsules.
  • Frequency: It’s typically taken once daily, usually in the morning to prevent frequent urination during nighttime.
  • Follow doctor’s instructions: Always follow your healthcare provider’s instructions regarding dosage and frequency. Do not change the dosage or stop taking the medication without consulting your doctor, even if you start feeling better.
  • Take with food: It’s generally recommended to take Hydrochlorothiazide with food to minimize stomach upset.
  • Stay hydrated: Since Hydrochlorothiazide increases urine production, it’s important to stay adequately hydrated. Drink plenty of water unless otherwise instructed by your doctor.
  • Regular monitoring: Your doctor may periodically monitor your blood pressure and electrolyte levels while you’re on Hydrochlorothiazide to ensure the medication is working effectively and to prevent any potential side effects.
  • Don’t double dose: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

It’s crucial to use Hydrochlorothiazide exactly as prescribed by your healthcare provider to get the maximum benefit from the medication and minimize the risk of side effects. If you have any questions or concerns about how to use Hydrochlorothiazide, don’t hesitate to consult your doctor or pharmacist for clarification.

Other uses for this medicine

Some off-label uses of Hydrochlorothiazide may include:

  • Diabetes insipidus: a condition characterized by excessive thirst and urination due to kidney problems.
  • Calcium kidney stones: It may help prevent the formation of certain types of kidney stones by reducing the amount of calcium excreted in the urine.
  • Osteoporosis: Some research suggests that hydrochlorothiazide may help prevent bone loss and reduce the risk of fractures in postmenopausal women.

What special precautions should I follow?

Special precautions should be taken when using Hydrochlorothiazide. Here are some important considerations:

  • Electrolyte imbalances: Hydrochlorothiazide can cause electrolyte imbalances, such as low levels of potassium, sodium, and magnesium. Your doctor may recommend periodic blood tests to monitor electrolyte levels and may suggest dietary changes or supplements to address any deficiencies.
  • Dehydration: Since Hydrochlorothiazide increases urine production, it’s essential to stay adequately hydrated. Dehydration can lead to low blood pressure, dizziness, fainting, and electrolyte imbalances. Drink plenty of water unless otherwise instructed by your doctor.
  • Renal function: Hydrochlorothiazide is primarily excreted by the kidneys, so individuals with impaired renal function may require dosage adjustments or close monitoring while taking the medication.
  • Allergies and hypersensitivity: If you have a known allergy to sulfa drugs, you should avoid Hydrochlorothiazide, as it contains a sulfonamide moiety. Inform your doctor about any known allergies or adverse reactions to medications.
  • Pregnancy and breastfeeding: Hydrochlorothiazide should be used with caution during pregnancy, especially during the second and third trimesters, as it may affect fetal development and lead to complications. It may also pass into breast milk, so breastfeeding mothers should consult their healthcare provider before using the medication.
  • Interactions with other medications: Hydrochlorothiazide may interact with other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), lithium, corticosteroids, and certain diabetes medications. Inform your doctor about all prescription, over-the-counter, and herbal medications you are taking to avoid potential drug interactions.

Always follow your doctor’s instructions and discuss any concerns or questions you have about Hydrochlorothiazide or its precautions.

What special dietary instructions should I follow?

  • It’s essential to maintain a balanced diet while taking hydrochlorothiazide. Follow your doctor’s recommendations regarding salt (sodium) intake.
  • Hydrochlorothiazide is a diuretic, so it increases the amount of urine you produce. Ensure you stay adequately hydrated by drinking plenty of water unless advised otherwise by your doctor.
  • Avoid excessive consumption of potassium-rich foods like bananas, oranges, potatoes, and spinach unless your doctor advises otherwise. Hydrochlorothiazide can lead to potassium loss, so your doctor may recommend a diet rich in potassium or supplements.

What should I do if I forget a dose?

  • If you miss a dose of hydrochlorothiazide, take it as soon as you remember. However, if it’s close to your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
  • Do not double the dose to catch up. Taking more medication than prescribed can increase the risk of side effects and complications.
  • If you frequently forget doses, consider setting reminders or alarms on your phone or using a pill organizer to help you remember.

What side effects can this medication cause?

Hydrochlorothiazide, like any medication, can cause side effects, although not everyone experiences them. Common side effects of Hydrochlorothiazide include:

  • Electrolyte imbalances: This medication can lead to low levels of potassium (hypokalemia), sodium (hyponatremia), and magnesium (hypomagnesemia), which may cause symptoms such as muscle weakness, fatigue, irregular heartbeat, and muscle cramps.
  • Dehydration: Increased urination can lead to dehydration, characterized by symptoms such as dry mouth, excessive thirst, weakness, dizziness, and dark-colored urine.
  • Orthostatic hypotension: Hydrochlorothiazide can cause a sudden drop in blood pressure when standing up from a sitting or lying position, leading to dizziness, lightheadedness, or fainting.
  • Increased uric acid levels: Hydrochlorothiazide can raise uric acid levels in the blood, which may worsen gout symptoms or increase the risk of developing gout.
  • Photosensitivity: Some individuals may experience increased sensitivity to sunlight while taking Hydrochlorothiazide, leading to sunburn or rash with sun exposure.
  • Skin reactions: Rarely, Hydrochlorothiazide can cause allergic skin reactions, such as rash, itching, hives, or photosensitivity.
  • Gastrointestinal effects: Nausea, vomiting, diarrhea, or abdominal pain may occur, although these side effects are relatively uncommon.
  • Kidney function: In rare cases, Hydrochlorothiazide may impair kidney function, leading to changes in urine output, blood urea nitrogen (BUN), or serum creatinine levels.
  • Glucose metabolism: Hydrochlorothiazide can affect glucose metabolism and may worsen glycemic control in individuals with diabetes mellitus.
  • Erectile dysfunction: Some men may experience erectile dysfunction or decreased libido while taking Hydrochlorothiazide.

It’s important to note that these side effects are not exhaustive, and some individuals may experience other adverse reactions. If you experience any unusual or persistent side effects while taking Hydrochlorothiazide, inform your healthcare provider promptly. They can assess the severity of the side effects and recommend appropriate measures, such as adjusting the dosage or switching to an alternative medication.

What should I know about storage and disposal of this medication?

Regarding the storage and disposal of Hydrochlorothiazide:


  • Room temperature: Store Hydrochlorothiazide at room temperature, away from moisture and heat.
  • Keep away from light: Store the medication in its original container or packaging, away from direct light.
  • Child-proof container: Keep Hydrochlorothiazide out of reach of children and pets, preferably in a child-proof container.
  • Avoid bathroom storage: Do not store Hydrochlorothiazide in the bathroom, as moisture and humidity can degrade the medication.
  • Proper closure: Ensure that the container is tightly closed when not in use to prevent moisture and contamination.


  • Follow guidelines: Dispose of expired or unused Hydrochlorothiazide following local regulations or guidelines. Do not flush medications down the toilet unless instructed to do so.
  • Medication take-back programs: Check if there are any medication take-back programs in your area where you can safely dispose of unused medications.
  • Mix with undesirable substance: If no take-back programs are available, mix the unused medication with an undesirable substance (e.g., coffee grounds, cat litter) in a sealable bag before disposing of it in the trash.

In case of emergency/overdose

  • Seek medical attention: In case of overdose or emergency, such as severe dizziness, fainting, difficulty breathing, or irregular heartbeat, seek immediate medical attention or contact a poison control center (in the US, call 1-800-222-1222).
  • Provide information: Provide as much information as possible about the amount of Hydrochlorothiazide ingested, the time of ingestion, and any symptoms experienced.

What other information should I know?

  • Regular monitoring: Attend all scheduled appointments with your healthcare provider for regular monitoring of blood pressure, electrolyte levels, and kidney function while taking Hydrochlorothiazide.
  • Lab tests: Your doctor may recommend periodic blood tests to monitor electrolyte levels, kidney function, and other parameters to ensure the safe and effective use of Hydrochlorothiazide.
  • Avoid alcohol: Limit or avoid alcohol consumption while taking Hydrochlorothiazide, as alcohol can worsen certain side effects such as dizziness and dehydration.
  • Avoid driving or operating machinery: Hydrochlorothiazide may cause dizziness or drowsiness in some individuals. Avoid driving or operating machinery until you know how the medication affects you.
  • Inform healthcare providers: Inform all healthcare providers involved in your care, including dentists and pharmacists, about all medications you are taking, including prescription, over-the-counter, and herbal supplements, to avoid potential drug interactions.

By following these guidelines, you can ensure the safe storage, disposal, and use of Hydrochlorothiazide, as well as know what to do in case of emergency or overdose. Always consult your healthcare provider if you have any questions or concerns about your medication regimen.

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