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Durezol (Generic Difluprednate Ophthalmic)

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Why is this medication prescribed?

Difluprednate ophthalmic, marketed under the brand name Durezol, is a potent corticosteroid used to reduce inflammation and pain in the eyes following surgery. As a corticosteroid, difluprednate works by inhibiting the release of specific natural substances in the body, such as prostaglandins and leukotrienes, which are involved in the inflammatory response. This suppression of the inflammatory pathway helps to alleviate symptoms like swelling, redness, and pain.

How should this medicine be used?

Difluprednate ophthalmic is used topically as a liquid emulsion. It is often given four times a day to the injured eye or eyes, starting the day after surgery and continuing for two weeks, then twice a day for one week. Your health and the way you respond to treatment will likely determine how gradually your doctor will reduce your dose. Apply difluprednate eye drops daily at roughly the same times. Pay close attention to the instructions on the label of your prescription and ask your pharmacist or doctor to explain anything you do not understand. As recommended, use difluprednate ophthalmic precisely. Use it exactly as advised by your doctor; do not take less or more of it.

Make sure the tip of the container of difluprednate eye drops stays away from your face, fingers, eyes, or any other surface when using it. Bacteria could enter the eye drops if the tip does come into contact with another surface. Using bacterially contaminated eye drops might result in severe eye damage or blindness. Get in touch with your pharmacist or physician if you believe your eye drops are contaminated.

Other uses for this medicine

Ask your doctor or pharmacist for more information if you think this medicine could be recommended for something else.

What special precautions should I follow?

Regarding special precautions for Difluprednate ophthalmic, here are some key points to consider:

  • If you have an allergy to any of the ingredients in difluprednate eye drops, other steroid drugs, or any other medication, let your doctor and pharmacist know. Get an ingredient list from your pharmacist.
  • Inform your physician and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal remedies you now take or intend to use. Your doctor might need to carefully monitor you for any negative effects or adjust the dosages of your medications.
  • Use the eye medicines at least ten minutes apart if you are also using another eyedrop.
  • If you have an eye infection of any kind at the moment, let your doctor know. It’s likely that your doctor will advise against using difluprednate eye drops.
  • Inform your physician if you currently have or have ever had herpes simplex virus (which can lead to eye infections and cause sores on the face, lips, genitalia, and rectum) or glaucoma (a condition in which increasing pressure in the eye can cause a gradual loss of vision).
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Contact your physician if you become pregnant while using difluprednate eye drops.
  • If you wear contact lenses, let your doctor know. It’s possible that your doctor will advise you not to wear contact lenses while using difluprednate eye drops.
  • Difluprednate eye drops can raise the risk of some complications following cataract surgery, slow down the healing process following surgery, and increase the likelihood of developing an infection or making an existing one worse. If your discomfort and swelling don’t go down, or if you experience any of the following symptoms, such as red, swollen, or crusty eyelids; floating specks in your vision; feeling like something is in your eye; or eye redness, itching, tearing, or discharge, call your doctor immediately once.

Always follow your healthcare provider’s instructions and take Difluprednate ophthalmic exactly as prescribed to maximize its effectiveness and minimize the risk of side effects and antibiotic resistance.

What special dietary instructions should I follow?

Maintain your regular diet unless advised otherwise by your physician.

What should I do if I forget a dose?

Utilize the overlooked dosage as soon as you recall it. On the other hand, if the next dose is almost here, skip the one you missed and stick to your usual dosage plan. Never administer more eye drops to compensate for a dose that was missed.

What side effects can this medication cause?

Difluprednate ophthalmic is generally well-tolerated, but like any medication, it can cause side effects in some people. Common side effects of Difluprednate ophthalmic may include:

  • Blurred vision
  • Decrease in vision
  • Seeing a glare from lights or sun

Long-term usage of difluprednate eye drops may raise the risk of glaucoma development. Your doctor will most likely keep an eye on the pressure in your eyes if you use difluprednate eye drops for ten days or more. Discuss the potential hazards of using this drug with your physician.

Additional adverse effects are possible with difluprednate eye drops. If you have any odd side effects while taking this medicine, contact your doctor.

It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects not listed here. If you have concerns about any side effects while taking difluprednate, contact your healthcare provider for guidance. They can provide personalized advice and may adjust your treatment as needed.

What should I know about storage and disposal of this medication?

Storage and Disposal of Difluprednate ophthalmic:


  • Store Difluprednate ophthalmic at room temperature, typically between 15°C to 25°C (59°F to 77°F).
  • Keep the bottle tightly closed when not in use.
  • Protect it from light and moisture.
  • Do not freeze the medication.


  • Do not use Difluprednate ophthalmic beyond its expiration date.
  • Dispose of any unused medication properly, following local regulations for disposal of prescription medications.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so.

In case of emergency/overdose

Signs of Overdose:

  • While an overdose of Difluprednate ophthalmic when used as prescribed in the eyes is unlikely to be life-threatening, improper use (such as ingestion or excessive application) could lead to complications.
  • Symptoms of an overdose might include severe irritation, increased intraocular pressure, or systemic corticosteroid effects like Cushing’s syndrome if used excessively over a prolonged period.

Emergency Steps:

  • If Difluprednate ophthalmic is accidentally ingested, seek immediate medical attention or contact a Poison Control Center.
  • For excessive application, rinse the eyes with plenty of water and seek medical advice if you experience significant discomfort or other symptoms.

What other information should I know?

Usage Instructions:

  • Use Difluprednate ophthalmic exactly as prescribed by your healthcare provider.
  • Shake the bottle well before each use.
  • Do not touch the dropper tip or let it come into contact with your eye or any other surface to avoid contamination.
  • Apply the drops while tilting your head back and pulling down the lower eyelid to create a small pocket.


  • Inform your doctor if you have any allergies, medical conditions, or are taking other medications.
  • Do not use Difluprednate ophthalmic if you have a fungal, viral, or bacterial infection in your eye unless prescribed by your doctor.
  • Long-term use of Difluprednate ophthalmic can increase the risk of glaucoma, cataracts, and secondary eye infections. Regular eye check-ups are recommended.


  • Inform your healthcare provider of all the medications and supplements you are taking, as Difluprednate ophthalmic may interact with other drugs.

Side Effects:

  • Common side effects include eye pain, headache, and increased intraocular pressure.
  • Severe side effects may include vision changes, eye infection, or severe eye irritation. Seek medical attention if you experience any severe or persistent side effects.

By adhering to these guidelines, you can ensure the safe and effective use of Difluprednate ophthalmic, minimize the risk of complications, and know how to respond in case of an emergency or overdose. Always consult your healthcare provider for personalized advice and information.

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