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DTIC-Dome (Generic Dacarbazine)

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Dacarbazine injection must be administered in a hospital or other healthcare institution under the direction of a physician with training in administering chemotherapy drugs for cancer.

Your bone marrow’s ability to produce blood cells may be severely affected by dacarbazine. This could result in specific symptoms and raise your risk of getting a major infection or bleeding. Your doctor may decide to halt or postpone your therapy if your blood cell count is low. Call your doctor right away if you have any of the following symptoms: Unusual bleeding or bruises; fever, sore throat, persistent cough, and congestion, among other infection-related symptoms.

Dacarbazine may seriously harm or endanger the liver. Those who are receiving dacarbazine treatment in addition to other cancer chemotherapy medications may experience liver damage more frequently. Call your doctor right away if you have any of the following symptoms: nausea, excessive fatigue, unusual bruising or bleeding, low energy, appetite loss, pain in the upper right portion of the stomach, or yellowing of the skin or eyes.

Animals that received dacarbazine injections experienced birth abnormalities. Although pregnant women have not been examined for this medicine, it is likely that babies born to moms who had dacarbazine injection during pregnancy may also be born with birth abnormalities. Unless your doctor determines that dacarbazine injection is the best treatment for your disease, you shouldn’t use it while you are pregnant or want to get pregnant.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to dacarbazine, your doctor will prescribe a number of tests.

Discuss the dangers of using dacarbazine injection with your doctor.

Why is this medication prescribed?

Dacarbazine is used to treat melanoma, a kind of skin cancer, once it has spread to other body regions. Dacarbazine is also used to treat Hodgkin’s lymphoma, a type of cancer that originates in the white blood cells that normally fight infection (Hodgkin’s disease), either alone or in combination with other medications. Dacarbazine belongs to the group of medications known as purine analogues. It works by slowing down or stopping the growth of cancer cells in your body.

How should this medicine be used?

A doctor or nurse will mix powder and liquid to administer dacarbazine injection intravenously (into a vein) over a period of one minute or intravenously (over a period of 15 to 30 minutes) in a medical setting. While treating melanoma, dacarbazine may be injected once daily for 10 consecutive days every 4 weeks or once daily for 5 consecutive days every 3 weeks. While treating Hodgkin’s lymphoma, dacarbazine may be administered intravenously once every four weeks for five consecutive days, or once every fifteen days.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving dacarbazine,

  • If you have an allergy to dacarbazine, any other drugs, or any of the ingredients in dacarbazine injection, let your doctor and pharmacist know right away. Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use.
  • Tell your doctor if you are breast-feeding.
  • Have a plan to limit your time spent in the sun and to use sunscreen, sunglasses, and protective clothes. Your skin could become photosensitive when using dacarbazine.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

There may be negative effects from dacarbazine. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Reduced appetite
  • Diarrhoea
  • Mouth- and throat-related sores
  • Hair fall
  • Tingling or scorching sensation on the face
  • Flushing
  • Flu-like signs

Some adverse effects may be severe. Call your doctor right away if you have any of the following symptoms or any of the ones detailed in the IMPORTANT CAUTION section:

  • Redness, discomfort, swelling, or burning at the injection site
  • Hives
  • Body rash
  • Itching
  • Breathing or swallowing challenges
  • Fever, muscle soreness, and a generalised sense of agony and exhaustion

Further negative effects of dacarbazine are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • DTIC-Dome®
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