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Doxylamine and Pyridoxine

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Why is this medication prescribed?

Doxylamine and pyridoxine are often prescribed together as a treatment for nausea and vomiting during pregnancy, a condition commonly known as morning sickness.

Doxylamine is an antihistamine that works by blocking the action of histamine, a substance in the body that can cause nausea and vomiting. Pyridoxine, also known as vitamin B6, is thought to help alleviate nausea by regulating neurotransmitters in the brain.

How should this medicine be used?

Doxylamine and pyridoxine are typically prescribed together in the form of a combination tablet or medication specifically designed for the treatment of nausea and vomiting during pregnancy. The dosage and frequency of use will depend on your individual circumstances and the instructions provided by your healthcare provider. However, here are some general guidelines:

  • Follow your doctor’s or pharmacist’s instructions carefully. They will provide you with specific guidance tailored to your condition.
  • Typically, the recommended dosage for most individuals is one tablet at bedtime, and if necessary, one tablet in the morning or early afternoon.
  • Take the medication orally with a full glass of water unless directed otherwise by your healthcare provider.
  • It’s essential to take the medication as prescribed, even if you start feeling better. Do not exceed the recommended dosage unless instructed by your healthcare provider.
  • If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.
  • Store the medication according to the instructions provided on the packaging or by your pharmacist. Keep it out of reach of children and away from moisture and heat.
  • If you experience any unusual or severe side effects while taking doxylamine and pyridoxine, contact your healthcare provider immediately.

Always consult your healthcare provider if you have any questions or concerns about how to use doxylamine and pyridoxine properly, especially during pregnancy. They can provide personalized guidance based on your medical history and current condition.

Other uses for this medicine

While doxylamine and pyridoxine are primarily prescribed for the treatment of nausea and vomiting during pregnancy, they may also be used off-label for other conditions. Some healthcare providers might prescribe them for certain cases of nausea and vomiting unrelated to pregnancy, but this usage should be guided by a healthcare professional’s advice.

What special precautions should I follow?

As for special precautions:

  • Pregnancy and breastfeeding: While doxylamine and pyridoxine are commonly used during pregnancy for nausea and vomiting, it’s essential to discuss the risks and benefits with your healthcare provider. They can provide guidance based on your individual situation. If you’re breastfeeding, consult your doctor before using these medications, as small amounts of the drugs may pass into breast milk.
  • Allergies: Inform your healthcare provider if you have any allergies to doxylamine, pyridoxine, or any other medications. This information is crucial to prevent adverse reactions.
  • Medical conditions: Disclose any medical conditions you have, such as asthma, glaucoma, urinary retention, liver disease, or kidney disease. These conditions may affect the safety and effectiveness of doxylamine and pyridoxine.
  • Interactions: Inform your doctor about all the medications, supplements, and vitamins you’re currently taking, as they may interact with doxylamine and pyridoxine. This includes prescription and over-the-counter medications.
  • Driving and operating machinery: Doxylamine may cause drowsiness and impair your ability to drive or operate machinery. Avoid activities that require alertness until you know how the medication affects you.
  • Alcohol: Avoid consuming alcohol while taking doxylamine and pyridoxine, as it can increase the risk of drowsiness and other side effects.
  • Overdose: Taking more than the recommended dosage of doxylamine and pyridoxine can lead to overdose, which may cause serious symptoms. Seek immediate medical attention if you suspect an overdose.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about using doxylamine and pyridoxine safely. They can provide personalized advice based on your medical history and current medications.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are no specific dietary restrictions associated with the use of doxylamine and pyridoxine. However, maintaining a healthy and balanced diet is generally recommended during pregnancy and in general for overall well-being. You can continue with your regular diet unless your healthcare provider advises otherwise.

What should I do if I forget a dose?

If you forget a dose of doxylamine and pyridoxine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Doxylamine and pyridoxine, like any medication, can cause side effects. Common side effects may include:

  • Drowsiness or sedation: Doxylamine is an antihistamine with sedative properties, so drowsiness is a common side effect. This can impair your ability to perform tasks that require alertness, such as driving or operating machinery.
  • Dry mouth: Antihistamines like doxylamine can cause dry mouth, which may increase the risk of dental issues such as tooth decay or gum disease.
  • Dizziness: Some individuals may experience dizziness or lightheadedness while taking doxylamine and pyridoxine.
  • Headache: Headaches are a possible side effect of these medications.
  • Blurred vision: Doxylamine can cause temporary changes in vision, such as blurred vision.
  • Gastrointestinal upset: Nausea, vomiting, or stomach discomfort may occur in some individuals.
  • Constipation: Doxylamine can slow down bowel movements, leading to constipation in some people.
  • Increased heart rate: In rare cases, individuals may experience palpitations or an increased heart rate while taking doxylamine.
  • Allergic reactions: While uncommon, allergic reactions to doxylamine and pyridoxine can occur. Seek medical attention immediately if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s essential to discuss any side effects you experience with your healthcare provider, especially if they are severe or persistent. They can provide guidance on managing side effects or adjusting your treatment plan if necessary. Additionally, if you have any concerns about potential side effects, discuss them with your doctor before starting the medication.

What should I know about storage and disposal of this medication?

Here’s what you should know about the storage and disposal information regarding doxylamine and pyridoxine:


  • Store doxylamine and pyridoxine tablets at room temperature away from moisture and heat.
  • Keep the medication out of reach of children and pets to prevent accidental ingestion.
  • Follow any specific storage instructions provided by your pharmacist or on the medication packaging.


  • Dispose of expired or unused doxylamine and pyridoxine tablets properly according to local regulations.
  • Do not flush medications down the toilet unless instructed to do so. Instead, consult your pharmacist or local waste disposal authority for guidance on proper disposal methods.

In case of emergency/overdose

  • If you suspect an overdose of doxylamine and pyridoxine, seek immediate medical attention or contact your local poison control center.
  • Symptoms of overdose may include extreme drowsiness, confusion, hallucinations, seizures, rapid heart rate, and difficulty breathing.
  • Be prepared to provide information about the medication and the amount ingested to healthcare professionals.

What other information should I know?

  • Inform your healthcare provider if you experience any new or worsening symptoms while taking doxylamine and pyridoxine.
  • Attend all scheduled appointments with your doctor for monitoring and evaluation of your condition.
  • Avoid consuming alcohol while taking doxylamine and pyridoxine, as it can increase the risk of drowsiness and other side effects.
  • Follow your doctor’s instructions carefully regarding dosage and timing of the medication.
  • Inform any other healthcare providers, including dentists and pharmacists, that you are taking doxylamine and pyridoxine.
  • Do not share your medication with others, even if they have similar symptoms.

By following these guidelines, you can ensure the safe and effective use of doxylamine and pyridoxine for the treatment of nausea and vomiting during pregnancy or other conditions as prescribed by your healthcare provider.

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