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Doxil (Generic Doxorubicin Lipid Complex Injection)

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WARNING

Any time during your treatment or months to years after it has stopped, doxorubicin lipid complex may result in significant or life-threatening heart issues. Before and during your treatment, your doctor will request tests to see whether your heart is healthy enough for you to safely take doxorubicin lipid complex. These tests could involve an electrocardiogram (ECG), which records the electrical activity of the heart, and an echocardiogram, which gauges the heart’s capacity to pump blood using sound waves. If tests reveal that your heart’s capacity to pump blood has deteriorated, your doctor could advise against taking this drug. If you have or have previously had a form of heart illness or radiation (x-ray) therapy to the chest area, let your doctor know. Inform your doctor and pharmacist if you are currently taking or have ever taken any of the following cancer chemotherapy drugs: paclitaxel (Abraxane, Onxol), cyclophosphamide (Cytoxan), daunorubicin (Cerubidine, DaunoXome), epirubicin (Ellence), idarubicin (Idamycin), mitoxantrone (Novantrone), trastuzumab (Her (Calan, Isoptin). Call your doctor right away if you have any of the following symptoms: breathing difficulties, hand, foot, ankle, or lower leg edoema, or a rapid, erratic, or pounding heartbeat.

Upon receiving a dose of doxorubicin lipid complex injection, you run the risk of having a significant allergic response. If you suffer any of these symptoms while receiving doxorubicin lipid complex, speak with your doctor or nurse right away. Hives, rash, itching, face, eye, mouth, throat, tongue, or lip swelling; flushing; fever; chills; backache; headache; difficulty breathing; shortness of breath; or tightness in the chest.

The amount of blood cells in your bone marrow may drastically decline as a result of doxorubicin treatment. Before to and throughout your treatment, your doctor will frequently order laboratory testing. A reduction in blood cell count in your body may result in certain symptoms and raise your risk of bleeding or serious infection. Inform your physician and pharmacist if you are currently taking or have recently taken progesterone, methotrexate (Rheumatrex), azathioprine (Imuran), or cyclosporine (Neoral, Sandimmune) (Provera, Depo-Provera). Call your doctor right away if you experience any of the following symptoms: fever, sore throat, persistent cough, congestion, or other infection-related symptoms; unusual bleeding or bruising; bloody or black, tarry stools; bloody vomit; or vomiting blood or brown material that resembles coffee grounds.

If you have liver illness now or ever had it, let your doctor know. If you have liver illness, your doctor might need to adjust your dosage.

Why is this medication prescribed?

Ovarian cancer that has not improved or that has gotten worse after treatment with other drugs is treated with doxorubicin lipid complex. Doxorubicin lipid complex is also used to treat Kaposi’s sarcoma, an AIDS-related disease that causes abnormal tissue to form on many parts of the body and that has not improved or gotten worse after treatment with other drugs. Multiple myeloma, a kind of bone marrow cancer, is also treated with doxorubicin lipid complex in combination with another chemotherapeutic agent when it has not improved or has gotten worse after treatment with other drugs. Anthracyclines are a group of drugs that include doxorubicin lipid complex. It functions by reducing or halting the development of cancer cells within your body.

How should this medicine be used?

A doctor or nurse will administer the doxorubicin lipid complex intravenously (into a vein) over the course of an hour in a medical setting. Doxorubicin lipid complex is administered once every four weeks while treating ovarian cancer. Doxorubicin lipid complex is administered once every three weeks while treating Kaposi’s sarcoma. Doxorubicin lipid complex is administered on particular days every three weeks for treating multiple myeloma.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving doxorubicin lipid complex,

  • If you have an allergy to doxorubicin, any other drugs, or any of the ingredients in doxorubicin lipid complex injection, let your doctor and pharmacist know right once. Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention any of the following medications as well as those in the IMPORTANT WARNING section if applicable: phenobarbital (Luminal Sodium), phenytoin, or some chemotherapy drugs such cytarabine (DepoCyt), dexrazoxane (Zinecard), mercaptopurine (Purinethol), and streptozocin (Zanosar) (Dilantin). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Do not forget to inform your doctor about any medications you are taking, even ones that are not on this list, as they can interact with doxorubicin lipid complex.
  • If you have or have ever had any additional medical conditions, let your doctor know.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. While getting doxorubicin lipid complex, you shouldn’t get pregnant or breastfeed. Call your doctor if you conceive while taking doxorubicin lipid complex. The foetus could suffer from doxorubicin lipid complex.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Side effects from doxorubicin lipid complex are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Reduced appetite (or weight loss)
  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Constipation
  • Unexpected fatigue or weakened state
  • Dizziness
  • Hair fall
  • Nosebleed
  • Urine that is coloured red or orange

Certain adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT CAUTION section:

  • Mouth- and throat-related sores
  • In the palms of the hands or soles of the feet, there may be tingling, burning, redness, swelling, peeling or flaking, blisters, or sores
  • Where the drug was injected, any discomfort, tingling, itching, redness, swelling, blisters, or sores

Further negative consequences from doxorubicin lipid complex are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Mouth- and throat-related sores
  • Fever, chills, a sore throat, or other symptoms of infection
  • Uncommon bruising or bleeding
  • Stool that is dark and tarry
  • Bench with a reddish tint
  • Tainted vomit
  • Vomited substance that resembles coffee grounds

What other information should I know?

Keep all of your appointments with your physician and the lab. To determine how your body is reacting to the doxorubicin lipid complex, your doctor will prescribe a number of tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Doxil®
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