Adults with a specific type of endometrial cancer (cancer that starts in the lining of the uterus) that has advanced or returned after receiving treatment with another chemotherapy drug may be given the injectable dostarlimab-gxly (s). Adults who were previously treated unsuccessfully with another chemotherapeutic drug and have no other effective treatment alternatives may also use dostarlimab-gxly injection to treat a specific form of solid tumour that has progressed to other areas of the body. Dostarlimab-gxly injection belongs to the group of drugs known as monoclonal antibodies. It functions by preventing a specific protein in cancer cells from doing its job. This aids in slowing the growth of tumours and aids the immune system’s defence against cancer cells.

A doctor or nurse can administer the dostarlimab-gxly injection intravenously (into a vein) over the course of 30 minutes at a hospital or infusion centre. Typically, it is administered once every three weeks for four cycles, once every six weeks for the remainder of the recommended treatment period from your doctor.

During an infusion, dostarlimab-gxly injection may result in adverse effects that are severe or potentially fatal. When you are receiving the infusion, a doctor or nurse will keep a close eye on you to make sure you are not having a dangerous response to the medication. If you develop any of the symptoms listed below while receiving the infusion, contact your doctor or nurse right away. They include chills, flushing, shaking, dizziness, shortness of breath, wheezing, fever, itching, rash, back or neck discomfort, and feeling dizzy.

Depending on how you react to the drug and any side effects you have, your doctor may reduce the rate of your infusion, cease your dostarlimab-gxly injectable treatment permanently or temporarily, or administer additional medication. Tell your doctor how you are feeling as you receive treatment.

You will receive the manufacturer’s patient information leaflet (Medication Guide) from your physician or chemist when you start receiving dostarlimab-gxly injection and each time you have your prescription filled. If you have any questions, carefully read the information and ask your doctor or chemist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

Before receiving dostarlimab-gxly injection,

• If you have any allergies, including to any inactive substances in dostarlimab-gxly injection, tell your doctor right away. For a list of the ingredients, consult the Medication Guide or speak with your chemist.
• Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Inform your doctor if you have undergone bone marrow or organ transplantation, as well as if you are undergoing or have undergone chest radiation therapy; a disorder that is autoimmune, like Crohn’s disease (condition in which the immune system attacks the lining of the digestive tract causing pain, diarrhea, weight loss, and fever), either lupus, in which the immune system assaults several tissues and organs, including the skin, joints, blood, and kidneys, or ulcerative colitis, a disorder that produces swelling and ulcers in the lining of the colon (large intestine) and rectum; any condition that affects your nervous system, such as myasthenia gravis (a nervous system disorder that results in muscle weakness) or Guillain-Barré syndrome (a condition that causes weakness, tingling, and potentially paralysis due to sudden nerve damage); any form of lung disease or breathing issues; thyroid issues; or liver disease.
• If you are pregnant or plan to become pregnant, let your doctor know. Before receiving dostarlimab-gxly, a pregnancy test will be required of you. Pregnancy should be avoided for at least 4 months following your final dose of dostarlimab-gxly injection as well as while you are getting it. Call your doctor right away if you became pregnant while receiving dostarlimab-gxly injection. The foetus could suffer from the injection of dostarlimab-gxly.
• If you are currently breastfeeding or intend to do so, let your doctor know. While having the dostarlimab-gxly injection and for 4 months following your last dose, you shouldn’t breastfeed.

Keep eating normally unless your doctor instructs you otherwise.

Call your doctor as soon as you can if you are unable to keep a dostarlimab-gxly injection appointment.

Dostarlimab-gxly could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Nausea
• Constipation
• Fatigue
• Joint or muscle ache

Certain adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you have any of these symptoms or those in the HOW section:

• Chest pain, a cough, or breathlessness
• Diarrhoea, more frequent bowel motions, bloody or mucus-filled stools, or stools that are black, tarry, or sticky; or discomfort in the abdominal region
• Dark urine, easy bleeding or bruising, loss of appetite, severe nausea or vomiting, low energy, or pain on the right side of the stomach area are some symptoms to watch out for
• Headaches, particularly ones that are unusual or persistent
• Alterations in behaviour or mood (decreased sex drive, irritability, or forgetfulness)
• Voice getting deeper or sounding hoarse
• Variations in weight (gain or loss)
• Weakness
• Hair fall
• Nausea or fainting
• Vision alterations
• Increased perspiration
• More frequent urination
• Increased light sensitivity
• Rapid heart rate
• Feeling thirstier orhungerier than normal
• Being chilly
• Blood in the urine, ankle edoema, change in urine volume or colour, or appetite loss
• Pale skin or breathing difficulty
• Itching, rash, blisters, sores, or ulcers on the skin; sores or ulcers in the mouth, nose, throat, or genital region; Swollen lymph nodes, flu-like symptoms, or a fever
• Diarrhoea, stomach ache, or a rash
• Lymph nodes that are swollen, a rash or sensitive skin lumps, a cough, shortness of breath, changes in eyesight, or eye pain
• Disorientation, fever, weakened muscles, issues with balance, nausea, vomiting, stiff neck, forgetfulness, or convulsions
• Hallucinations (seeing things or hearing voices that do not exist)

Dostarlimab-gxly could have other negative effects. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Maintain all scheduled times with your physician and the lab. To determine how your body is responding to dostarlimab-gxly, your doctor will request a number of lab tests. To determine whether dostarlimab-gxly can be used to treat your cancer, your doctor will have a lab test done before you start your therapy.

Any inquiries regarding dostarlimab-gxly should be directed to your pharmacist.

You should keep a written record of every drug you take, including prescription and nonprescription (over-the-counter) medications, vitamins, minerals, and other dietary supplements. Every time you see a doctor or are admitted to the hospital, you should carry this list with you. Also, it is crucial to have this knowledge on hand in case of emergency.