Adults with human immunodeficiency virus (HIV) infections who have not received other HIV medications are treated with doravirine in combination with other drugs. Moreover, it is used to replace ongoing drug therapy in some HIV-positive individuals. Doravirine belongs to a group of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). It functions by lowering the blood’s HIV concentration. Doravirine may lower your risk of getting HIV, AIDS, and HIV-related diseases such severe infections or cancer even though it does not treat HIV. It is possible to reduce the risk of spreading the HIV virus to other people by taking these medications, engaging in safer sexual behaviour, and changing other aspects of one’s lifestyle.

The oral tablet form of doravirine is available. Typically, it is taken once daily with or without food. Doravirine should be taken every day at around the same time. Ask your doctor or chemist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Just as prescribed, take doravirine. Never take it in quantities or frequencies other than those recommended by your doctor.

Although it does not treat HIV infection, doravirine aids in its control. Even if you feel good, keep taking doravirine. Without consulting your doctor, do not discontinue taking doravirine. It can be more challenging to treat your disease if you stop taking doravirine or miss doses. Ask your doctor or chemist for more doravirine when you start to run low on it.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

Before taking doravirine,

• If you have an allergy to doravirine, any other medications, or any of the substances in doravirine tablets, let your doctor and chemist know right once. Get an ingredient list from your chemist.
• Inform your doctor if you’re taking any of the following medications: phenobarbital, oxcarbazepine (Trileptal), mitotane (Lysodren), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), rifapentine (Priftin), or St. John’s wort. If you are presently taking any of these drugs or have recently taken one of them within the last four weeks, your doctor will probably advise you not to take doravirine.
• Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. efavirenz (Sustiva, in Atripla), etravirine (Intelence), or nevirapine should be mentioned (Viramune). Moreover, let your doctor know whether you are currently taking or just stopped taking rifabutin (Mycobutin). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all of the medications you are taking, even any not on this list, since many other drugs may also interact with doravirine.
• Inform your doctor if you have or have ever had a recurring or intermittent illness, such as cytomegalovirus (CMV; a viral infection that may cause symptoms in patients with weak immune systems),pneumonia, tuberculosis, mycobacterium avium complex disease (MAC), or an autoimmune disease (conditions that arise when the immune system mistakenly attacks healthy cells in the body), such as Graves’ disease (condition where the body attacks the thyroid gland causing it to be overactive), polymyositis, could all result in serious symptoms in people with AIDS (condition that causes muscle weakness but not skin rash), Guillain-Barré syndrome, autoimmune hepatitis, and weakness, tingling, and perhaps paralysis as a result of abrupt nerve injury (condition in which the cells of the immune system attack the liver).
• If you are pregnant or plan to become pregnant, let your doctor know. Call your doctor if you become pregnant while taking doravirine. Inform your doctor if you are nursing a child. If you have an HIV infection or are taking doravirine, you should not breastfeed.
• You should be aware that while you use medications to treat your HIV infection, your immune system could become stronger and start to fight other infections you previously have in your body or trigger the development of other illnesses. You might start to exhibit signs of certain illnesses as a result of this. During your doravirine treatment, be sure to let your doctor know if you experience any new or worsening symptoms.

Keep eating normally unless your doctor instructs you otherwise.

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

Doravirine might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Headache
• Tiredness
• Abdominal pain
• Strange dreams
• Having trouble falling or staying asleep
• Dizziness

Further negative effects of doravirine could exist. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom). The tablets should not be kept in a pillbox or a pill organiser. Removing the desiccant (drying agent) from the bottle is not advised.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to doravirine, your doctor will request specific lab tests.

Doravirine should always be available. Do not wait until you are out of medication before ordering more.

Never allow someone else to take your medication. If you have any queries regarding getting a prescription renewed, ask your chemist.

You should keep a written record of every drug you take, including prescription and nonprescription (over-the-counter) medications, vitamins, minerals, and other dietary supplements. Every time you see a doctor or are admitted to the hospital, you should carry this list with you. Also, it is crucial to have this knowledge on hand in case of emergency.