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DOR/3TC/TDF (Generic Doravirine, Lamivudine, and Tenofovir)

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Doravirine, Lamivudine, and Tenofovir are commonly used antiretroviral drugs for the treatment of HIV infection. While they are generally safe and effective, like all medications, they carry some risks:

  • Drug Interactions: These drugs can interact with other medications, including over-the-counter drugs and supplements. It’s important to consult with a healthcare provider to avoid potential interactions that could reduce their effectiveness or cause harmful side effects.
  • Side Effects: Common side effects of these medications may include nausea, diarrhea, headache, fatigue, and dizziness. Some individuals may experience more severe side effects such as liver problems or allergic reactions. Monitoring by a healthcare provider is crucial to detect and manage any adverse effects.
  • Resistance: If these medications are not taken consistently or as prescribed, there is a risk of developing drug resistance, which can limit future treatment options. It’s essential to adhere to the prescribed regimen and attend regular medical appointments for monitoring.
  • Bone and Kidney Health: Tenofovir, in particular, has been associated with decreased bone mineral density and kidney problems in some individuals. Regular monitoring of bone and kidney health is recommended for those taking these medications long-term.
  • Liver Function: These drugs can affect liver function, especially in individuals with pre-existing liver disease. Monitoring liver function tests is important to detect any abnormalities early on.
  • Pregnancy Considerations: Pregnant individuals or those planning to become pregnant should discuss the risks and benefits of these medications with their healthcare provider. Some antiretroviral drugs may have implications for pregnancy and fetal health.
  • Lipid Levels: Doravirine may affect lipid levels, leading to increases in cholesterol and triglycerides. Regular monitoring of lipid levels is recommended, especially in individuals with existing cardiovascular risk factors.

Overall, while these medications are effective in managing HIV infection, careful monitoring and adherence to treatment guidelines are essential to minimize risks and optimize outcomes.

Why is this medication prescribed?

The combination of doravirine, lamivudine, and tenofovir is used to treat human immunodeficiency virus (HIV) infection in adults and children weighing more than 77 pounds (35 kg) who have not been treated with other HIV medications. For some adults and children over the age of 77 pounds (35 kg) who are already receiving HIV medicine, the combination can also be administered in place of their current therapy. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a group of drugs that includes doravirine. Within the class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs) is lamivudine and tenofovir. The way that doravirine, lamivudine, and tenofovir function together is by reducing the body’s level of HIV. While doravirine, lamivudine, and tenofovir alone cannot cure HIV, they can lower your risk of contracting HIV-related diseases like cancer and severe infections as well as other HIV-related disorders. The risk of HIV transmission to others may be reduced by taking these drugs, engaging in safer sexual behavior, and adopting other lifestyle modifications.

How should this medicine be used?

As for how they should be used:

  • Dosage: The specific dosage of Doravirine, Lamivudine, and Tenofovir can vary depending on factors such as the individual’s weight, renal function, and other medications they may be taking. It’s crucial to follow the dosage instructions provided by the healthcare provider.
  • Administration: These medications are usually taken orally, with or without food, as directed by the healthcare provider. They are often taken once daily for ease of adherence.
  • Adherence: It’s essential to take these medications consistently and as prescribed to achieve the best treatment outcomes. Missing doses or not following the prescribed regimen can lead to treatment failure and the development of drug-resistant HIV strains.
  • Monitoring: Individuals taking Doravirine, Lamivudine, and Tenofovir will typically undergo regular monitoring, including blood tests to assess HIV viral load, CD4 cell count, kidney function, and liver function. This helps healthcare providers evaluate the effectiveness of the treatment and detect any potential side effects early.

Overall, adherence to the prescribed treatment regimen and regular monitoring are crucial for the successful management of HIV infection with Doravirine, Lamivudine, and Tenofovir.

Other uses for this medicine

Ask your doctor or pharmacist for more information if you think this medicine could be recommended for something else.

What special precautions should I follow?

As for special precautions to follow when taking Doravirine, Lamivudine, and Tenofovir:

  • Adherence to Treatment: It’s crucial to take these medications exactly as prescribed by the healthcare provider to ensure optimal effectiveness and minimize the risk of developing drug resistance.
  • Regular Monitoring: Individuals taking these medications should undergo regular monitoring, including blood tests to assess HIV viral load, CD4 cell count, kidney function, and liver function. This helps healthcare providers evaluate the effectiveness of the treatment and detect any potential side effects early.
  • Drug Interactions: Inform your healthcare provider about all other medications, supplements, and over-the-counter drugs you are taking to avoid potential interactions that could affect the effectiveness or safety of Doravirine, Lamivudine, and Tenofovir.
  • Kidney and Bone Health: Tenofovir, particularly the tenofovir disoproxil fumarate (TDF) form, has been associated with kidney toxicity and bone density loss in some individuals. Regular monitoring of kidney function and bone health is essential, especially with long-term use.
  • Liver Function: Lamivudine and Tenofovir may affect liver function in some individuals. Regular liver function tests are necessary to monitor for any signs of liver problems.
  • Pregnancy and Breastfeeding: Discuss with your healthcare provider the risks and benefits of using these medications during pregnancy or while breastfeeding. Some antiretroviral drugs may be used during pregnancy to prevent mother-to-child transmission of HIV, but the specific regimen may need to be adjusted based on individual circumstances.

By following these precautions and staying in close communication with your healthcare provider, you can maximize the benefits of Doravirine, Lamivudine, and Tenofovir while minimizing the risks.

What special dietary instructions should I follow?

  • Food: These medications can usually be taken with or without food. Follow the instructions provided by your healthcare provider or pharmacist regarding food intake with these medications.
  • Hydration: It’s essential to maintain adequate hydration, especially when taking Tenofovir, to help support kidney function and minimize the risk of kidney toxicity.

What should I do if I forget a dose?

  • Take the missed dose as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and take your next dose at the regular time.
  • Do not take a double dose to make up for a missed one.
  • If you’re unsure about what to do, or if you’ve missed multiple doses, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Doravirine, Lamivudine, and Tenofovir, like any medication, can cause side effects. Common side effects of Doravirine, Lamivudine, and Tenofovir may include:

  • Dizziness
  • Nausea
  • Abnormal dreams
  • Difficulty falling asleep or staying asleep
  • Drowsiness
  • Diarrhea
  • Headache

In addition to the common side effects, Doravirine, Lamivudine, and Tenofovir may also cause more serious side effects, although these are less common. These can include:

  • Decreased urination or swelling of legs
  • Bone pain; pain in arms or legs; muscle pain or weakness; or bone fracture

Doravirine, lamivudine, and tenofovir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What should I know about storage and disposal of this medication?

Storage and disposal of Doravirine, Lamivudine, and Tenofov:


  • Store these medications at room temperature away from moisture and heat.
  • Keep them in their original packaging or container to protect them from light.
  • Do not store them in the bathroom or near the kitchen sink, where they may be exposed to moisture.
  • Keep them out of reach of children and pets.


  • Dispose of any unused or expired medications properly according to local guidelines or recommendations.
  • Do not flush medications down the toilet or pour them down the drain unless instructed to do so.
  • Consult your pharmacist or healthcare provider for guidance on how to safely dispose of these medications.

In case of emergency/overdose

  • In case of an overdose or emergency, contact your local poison control center or emergency room immediately.
  • If possible, bring the medication container or packaging with you to the emergency room to help healthcare providers assess the situation and provide appropriate treatment.
  • Symptoms of overdose may include nausea, vomiting, dizziness, fatigue, and other side effects. Prompt medical attention is crucial in cases of overdose.

What other information should I know?

  • Inform all healthcare providers involved in your care, including dentists and pharmacists, that you are taking Doravirine, Lamivudine, and Tenofovir.
  • Attend all scheduled appointments for monitoring and follow-up with your healthcare provider.
  • Do not share these medications with others, even if they have similar symptoms or conditions.
  • Keep a list of all medications you are taking, including prescription drugs, over-the-counter medications, and supplements, and share it with your healthcare provider.
  • Follow your healthcare provider’s instructions closely, including dosing schedule, dietary recommendations, and any special precautions.
  • Report any new or worsening symptoms to your healthcare provider promptly.
  • Seek medical advice before starting any new medications or supplements while taking Doravirine, Lamivudine, and Tenofovir.

By following these guidelines and staying informed about the proper storage, disposal, emergency management, and other important information, you can safely and effectively manage your treatment with Doravirine, Lamivudine, and Tenofovir.

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