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Doptelet (Generic Avatrombopag)

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Why is this medication prescribed?

Doptelet is a medication primarily prescribed to increase platelet production in individuals with chronic liver disease who are preparing for a medical or dental procedure. Chronic liver disease can often lead to a decrease in platelet count, which may result in a higher risk of bleeding during surgical procedures or other medical interventions. Doptelet works by stimulating the production of platelets in the bone marrow, helping to increase platelet levels and reduce the risk of bleeding.

How should this medicine be used?

Doptelet (avatrombopag) is typically prescribed to increase platelet production in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. Here’s a general overview of how Doptelet is used:

  • Dosage: Your doctor will determine the appropriate dosage of Doptelet for you based on your individual medical condition, platelet count, and other factors. The usual starting dose is 60 mg once daily.
  • Administration: Doptelet is available as tablets for oral administration. It can be taken with or without food.
  • Timing: Doptelet is usually started 10 to 13 days before the scheduled procedure and continued until the day of the procedure. This timeframe allows for an increase in platelet count, reducing the risk of bleeding during the procedure.
  • Follow-up: Your doctor may monitor your platelet count regularly during treatment with Doptelet to assess its effectiveness and adjust the dosage if necessary.
  • Precautions: It’s essential to follow your doctor’s instructions carefully when taking Doptelet. Avoid taking any other medications, including over-the-counter supplements, without consulting your doctor first, as they may interact with Doptelet.
  • Side Effects: Like any medication, Doptelet can cause side effects. Common side effects may include headache, fatigue, swelling in the legs or arms, and nausea. If you experience any severe or persistent side effects, contact your doctor immediately.

Always consult your healthcare provider for specific instructions tailored to your individual needs and medical condition. They can provide guidance on the appropriate dosage, timing, and duration of treatment with Doptelet.

Other uses for this medicine

Some of these potential uses include:

  • Thrombocytopenia: Doptelet may be used in the treatment of thrombocytopenia (low platelet count) in conditions other than chronic liver disease, such as immune thrombocytopenia (ITP) or chemotherapy-induced thrombocytopenia.
  • Bone Marrow Disorders: It may also be considered in certain bone marrow disorders where there’s inadequate platelet production.
  • Surgical Procedures: Doptelet might be utilized in patients with other conditions associated with low platelet counts who are preparing for surgical or invasive procedures.

What special precautions should I follow?

Regarding special precautions for Doptelet, here are some key points to consider:

  • Liver Function: Since Doptelet is primarily metabolized by the liver, special caution is needed in patients with hepatic impairment. Dosage adjustments may be necessary in these individuals.
  • Thrombotic Events: Doptelet may increase the risk of thrombotic events (blood clots), particularly in patients with known risk factors for thrombosis. It’s essential to monitor patients for signs and symptoms of thrombosis during treatment.
  • Interactions: Doptelet may interact with certain medications, including anticoagulants and drugs that are metabolized by or affect liver enzymes. Your healthcare provider should be aware of all medications you are taking to minimize the risk of interactions.
  • Pregnancy and Breastfeeding: The safety of Doptelet during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Doptelet with your doctor.
  • Side Effects: Like any medication, Doptelet can cause side effects. It’s essential to report any adverse reactions to your healthcare provider promptly.

Always follow your doctor’s instructions carefully and communicate any concerns or questions you may have about Doptelet or its use in your treatment plan.

What special dietary instructions should I follow?

Regarding special dietary instructions for Doptelet, there are no specific dietary restrictions associated with its use. However, maintaining a healthy, balanced diet is always advisable for overall well-being.

What should I do if I forget a dose?

If you forget to take a dose of Doptelet, take it as soon as you remember on the same day. However, if it’s already close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Doptelet (avatrombopag) may cause side effects in some individuals, although not everyone will experience them. Common side effects of Doptelet include:

  • Headache: Mild to moderate headaches are commonly reported by some individuals taking Doptelet.
  • Fatigue: Feelings of tiredness or fatigue may occur during treatment with Doptelet.
  • Nausea: Some people may experience nausea or an upset stomach as a side effect of Doptelet.
  • Upper Respiratory Tract Infection: Symptoms such as a cough, sore throat, or nasal congestion may occur.
  • Muscle or Joint Pain: Some individuals may experience muscle aches or joint pain while taking Doptelet.
  • Swelling: Swelling in the legs, ankles, or feet may occur as a side effect of Doptelet.
  • Abnormal Liver Function Tests: Doptelet may cause changes in liver function tests, although these are typically mild and reversible.
  • Cataracts: In clinical studies, some patients treated with Doptelet developed cataracts.
  • Thrombotic Events: Although less common, Doptelet may increase the risk of thrombotic events, such as blood clots. Symptoms of a thrombotic event may include chest pain, shortness of breath, leg swelling, or sudden numbness or weakness.

It’s essential to report any side effects or unusual symptoms to your healthcare provider promptly. They can help determine whether any side effects you’re experiencing are related to Doptelet and provide guidance on managing them. Additionally, if you experience any severe or persistent side effects, seek medical attention immediately. Your healthcare provider may need to adjust your dosage or recommend alternative treatments if side effects are bothersome or concerning.

What should I know about storage and disposal of this medication?

When it comes to the storage and disposal of Doptelet (avatrombopag), here’s what you should know:


  • Store Doptelet tablets at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep the medication in its original container, tightly closed, and away from moisture and light.
  • Avoid storing Doptelet in the bathroom or kitchen, where humidity and temperature fluctuations may affect its stability.
  • Keep Doptelet out of reach of children and pets.


  • Dispose of any unused or expired Doptelet tablets properly.
  • Do not flush medications down the toilet or pour them down the drain unless instructed to do so by a healthcare professional or local waste disposal guidelines.
  • Consult your pharmacist or local waste disposal company for guidance on how to dispose of Doptelet safely and responsibly.

In case of emergency/overdose

In case of an emergency or suspected overdose of Doptelet, contact your local poison control center (1-800-222-1222 in the United States) or seek emergency medical attention immediately. Overdose symptoms may include nausea, vomiting, headache, fatigue, and increased risk of thrombotic events.

What other information should I know?

  • Inform all healthcare providers involved in your care that you are taking Doptelet, including dentists and surgeons, as it may affect certain medical procedures.
  • Attend all scheduled appointments with your doctor for monitoring of platelet count and overall health while taking Doptelet.
  • Keep a list of all medications you are taking, including Doptelet, and share it with your healthcare providers to avoid potential drug interactions.
  • Follow your doctor’s instructions carefully regarding dosage, administration, and any special precautions associated with Doptelet.

As always, if you have any questions or concerns about Doptelet or its use, consult your healthcare provider or pharmacist for guidance.

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