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Why is this medication prescribed?

Dolasetron is primarily prescribed to prevent nausea and vomiting caused by chemotherapy or radiation therapy. It belongs to a class of medications called serotonin 5-HT3 receptor antagonists, which work by blocking the action of serotonin, a natural substance in the body that can trigger nausea and vomiting.

How should this medicine be used?

Dolasetron is usually taken by mouth as a tablet. It can also be administered intravenously in certain medical settings. The dosage and frequency of administration depend on various factors such as the type of chemotherapy or radiation therapy, the individual’s medical condition, and their response to treatment.

Typically, it’s taken about an hour before chemotherapy or radiation therapy, and sometimes additional doses may be recommended to prevent nausea and vomiting in the days following treatment. It’s crucial to follow your doctor’s instructions regarding the dosage and schedule of dolasetron to ensure its effectiveness in managing nausea and vomiting.

Other uses for this medicine

Dolasetron is primarily used to prevent nausea and vomiting associated with chemotherapy or radiation therapy, but it may also be prescribed for other off-label uses, such as:

  • Postoperative nausea and vomiting (PONV): Dolasetron may be used to prevent nausea and vomiting after surgical procedures.
  • Nausea and vomiting associated with other medical conditions: In some cases, doctors may prescribe dolasetron to manage nausea and vomiting related to conditions other than chemotherapy or radiation therapy, though this usage would be considered off-label.

What special precautions should I follow?

As for special precautions, it’s essential to follow your doctor’s instructions and adhere to the following guidelines when taking dolasetron:

  • Inform your doctor about any allergies you have, especially if you are allergic to dolasetron or any other medications.
  • Disclose your medical history, including any heart rhythm problems (such as QT prolongation), liver disease, or electrolyte imbalances.
  • Inform your doctor about all the medications you are currently taking, including prescription and over-the-counter drugs, as well as any herbal supplements, to avoid potential interactions.
  • Avoid consuming alcohol while taking dolasetron, as it can increase the risk of side effects such as dizziness and drowsiness.
  • Take dolasetron exactly as prescribed by your doctor. Do not take more or less than the recommended dosage, and do not stop taking it without consulting your doctor first.
  • If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using dolasetron with your doctor.
  • Be cautious when driving or operating machinery, as dolasetron may cause dizziness or drowsiness.

By following these precautions and your doctor’s guidance, you can help ensure the safe and effective use of dolasetron for your specific medical needs.

What special dietary instructions should I follow?

As for special dietary instructions, there are no specific dietary restrictions associated with dolasetron. However, it’s always a good idea to maintain a balanced diet and stay hydrated, especially if you are undergoing chemotherapy or radiation therapy.

What should I do if I forget a dose?

If you forget to take a dose of dolasetron, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure about what to do, consult your doctor or pharmacist for guidance.

What side effects can this medication cause?

Dolasetron, like any medication, can cause side effects, although not everyone will experience them. Common side effects of dolasetron may include:

  • Headache
  • Dizziness
  • Drowsiness
  • Fatigue
  • Constipation
  • Diarrhea
  • Stomach pain
  • Flushing (reddening of the skin)
  • Injection site reactions (if administered intravenously)

Less common but more serious side effects may include:

  • Irregular heartbeat or heart rhythm problems (QT prolongation)
  • Allergic reactions, including rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing
  • Serotonin syndrome, which can cause symptoms such as agitation, hallucinations, fast heart rate, fever, sweating, shivering, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea
  • Neuroleptic malignant syndrome (NMS), a potentially life-threatening condition characterized by high fever, muscle rigidity, altered mental status, irregular pulse or blood pressure, rapid heart rate, excessive sweating, and rapid breathing

If you experience any severe or persistent side effects while taking dolasetron, contact your doctor immediately. Additionally, it’s essential to report any new or worsening symptoms to your healthcare provider to ensure proper management and treatment.

What should I know about storage and disposal of this medication?

When it comes to the storage and disposal of dolasetron, here are some important points to keep in mind:


  • Store dolasetron tablets or oral solution at room temperature away from light and moisture.
  • Keep it out of reach of children and pets.
  • Do not store dolasetron in the bathroom or near the kitchen sink, as moisture and heat can degrade the medication.


  • Dispose of any unused or expired dolasetron medication properly according to local regulations or guidelines.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Instead, consult your pharmacist or local waste disposal company for guidance on how to dispose of medications safely.

In case of emergency/overdose

In case of emergency or overdose of dolasetron, seek immediate medical attention or contact your local poison control center. Overdose symptoms may include severe dizziness, fainting, irregular heartbeat, or difficulty breathing.

What other information should I know?

  • Follow your doctor’s instructions regarding dosage, schedule, and duration of treatment.
  • Keep all appointments with your healthcare provider for monitoring and evaluation of your response to treatment.
  • Do not share dolasetron with others, even if they have similar symptoms or conditions, as it may not be suitable or safe for them.
  • Notify your healthcare provider of any new or worsening symptoms, as well as any side effects or concerns you may have while taking dolasetron.
  • Carry a list of all your medications, including dolasetron, and show it to any healthcare provider who treats you, such as doctors, dentists, or emergency room staff.

By adhering to these guidelines and staying informed about your medication, you can help ensure the safe and effective use of dolasetron for your medical condition.

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