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Using antiarrhythmic medications, such as disopyramide, may make death more likely. Inform your physician if you suffer from cardiac problems, such as heart failure or a valve issue (HF; condition in which the heart cannot pump enough blood to other parts of the body). Make a quick call to your doctor if you encounter any of the following signs: chest pain or erratic heartbeat.

Disopyramide concerns should be discussed with your doctor. Disopyramide may make arrhythmias (irregular heartbeats) more likely, and it hasn’t been shown to make it easier for people to live longer who don’t have life-threatening arrhythmias.

Why is this medication prescribed?

Some kinds of irregular heartbeats are treated with disopyramide). Disopyramide belongs to the class of drugs known as antiarrhythmic drugs. It functions by strengthening your heart’s defences against aberrant activity.

How should this medicine be used?

Extended-release (long-acting) capsules and capsules for oral administration of disopyramide are both available. Every 6 or 8 hours, disopyramide capsules can be used. Every 12 hours, the extended-release capsule is typically consumed. Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Follow the disopyramide directions exactly. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not open, chew, or crush the extended-release capsules; simply swallow them.

Disopyramide aids in managing your disease but cannot reverse it. Disopyramide should still be used even if you feel fine. Without consulting your doctor, do not discontinue taking disopyramide.

Other uses for this medicine

Ask your doctor or chemist for more details if you’re interested in using this medication for any other conditions.

What special precautions should I follow?

Before taking disopyramide,

  • If you have any allergies, including to disopyramide, any other medications, or any of the substances in disopyramide capsules, notify your doctor right away. Get a list of the ingredients from your chemist.
  • Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Clarithromycin, erythromycin (E.E.S., Eryc, Erythrocin, others), phenytoin (Dilantin, Phenytek), propranolol (Inderal, Innopran), and verapamil should all be mentioned (Calan, Tarka, Verelan). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have heart block (a disease in which electrical signals from the upper chambers of the heart are not properly transmitted to the lower chambers) or if your QT interval has ever been prolonged (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death). Your physician might advise against taking disopyramide.
  • If you have or have ever had heart disease, diabetes, glaucoma, myasthenia gravis (a nerve system ailment that causes muscle weakness), urinary retention, benign prostatic hypertrophy, kidney, or liver disease, let your doctor know.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking disopyramide.
  • If you are 65 years of age or older, discuss the advantages and disadvantages of taking disopyramide with your doctor. Disopyramide is typically not recommended for usage in older adults since it is less reliable and less efficient than alternative drugs that can be used to treat the same disease.
  • Inform your doctor or dentist that you are taking disopyramide if you are having surgery, including dental surgery.
  • Consult your doctor about whether drinking alcohol is safe while taking disopyramide. Disopyramide side effects can be exacerbated by alcohol.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Side effects from disopyramide are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Feeling unsteady or lightheaded
  • Problematic urination
  • Excessive urination
  • Mouth ache
  • Constipation
  • Fuzzy vision
  • Nausea
  • Fatigue
  • Headache
  • Weakness
  • Belly aches or bloating
  • Fatigue
  • Weakness
  • Headache
  • Rash

Certain adverse effects can be very harmful. Call your doctor right away if you have any of the following symptoms:

  • Chest ache
  • Edoema in the hands or feet
  • Unexpected weight gain
  • Unsteady heartbeat
  • Breathing difficulty
  • Abrupt alterations in mental state

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Sluggish or unpredictable heartbeat
  • Mouth ache
  • Having trouble urinating
  • Constipation
  • Consciousness is lost

What other information should I know?

Keep all of your appointments with your physician and the lab. Your physician needs to ascertain how you react to disopyramide.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Norpace®
  • Norpace® CR
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