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Dipivefrin Ophthalmic

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Why is this medication prescribed?

Dipivefrin ophthalmic is prescribed to treat certain eye conditions, primarily glaucoma and ocular hypertension. Glaucoma is a condition characterized by increased pressure within the eye, which can damage the optic nerve and lead to vision loss if left untreated. Dipivefrin works by reducing intraocular pressure (IOP) by increasing the drainage of aqueous humor from the eye.

How should this medicine be used?

Dipivefrin ophthalmic, commonly known by its brand name Propine, is used to treat high pressure inside the eye due to glaucoma or other eye diseases. It belongs to a class of drugs called alpha-adrenergic agonists.

Here’s how dipivefrin ophthalmic should typically be used:

  • Wash Your Hands: Before using the eye drops, wash your hands thoroughly with soap and water.
  • Prepare the Eye Drops: Shake the bottle well before using it to ensure that the medication is evenly mixed.
  • Tilt Your Head Back: Either lie down or tilt your head back and look upward toward the ceiling.
  • Create a Pocket: Gently pull down your lower eyelid with one hand to create a small pocket between your eyelid and your eye.
  • Administer the Drops: Hold the dropper tip directly over your eye, making sure not to touch the tip to your eye or any other surface to avoid contamination. Squeeze the prescribed number of drops into the pocket formed by your lower eyelid. Be careful not to blink or squeeze your eye while administering the drops.
  • Close Your Eye: Close your eye gently and apply light pressure to the inner corner of your eye with your finger for about 1 to 2 minutes. This helps to prevent the medication from draining out of your eye and being absorbed systemically.
  • Wipe Away Excess: If there is any excess medication around your eye, gently wipe it away with a clean tissue.
  • Repeat if Necessary: If you need to administer drops to both eyes, repeat the process for the other eye.
  • Wait Between Medications: If you are using other eye medications, wait at least 5 minutes before applying them after using dipivefrin ophthalmic. This helps to prevent dilution of the medication and ensures proper absorption.
  • Close the Bottle: After using the eye drops, securely close the bottle to prevent contamination.
  • Wash Your Hands Again: After administering the eye drops, wash your hands again to remove any residual medication.

It’s important to use dipivefrin ophthalmic exactly as prescribed by your doctor. Do not use more or less of it or use it more often than prescribed, as this can increase the risk of side effects or may not effectively control your condition. If you have any questions or concerns about how to use the medication, be sure to consult your doctor or pharmacist for guidance.

Other uses for this medicine

While dipivefrin is primarily indicated for glaucoma and ocular hypertension, some studies suggest potential off-label uses, including the treatment of retinal vein occlusion and diabetic retinopathy. However, the efficacy and safety of dipivefrin for these conditions are not well-established and should only be considered under the guidance of a healthcare professional.

What special precautions should I follow?

As for special precautions when using dipivefrin ophthalmic:

  • Use as Directed: Use the medication exactly as prescribed by your doctor. Do not use more or less of it or use it more often than prescribed.
  • Eye Examinations: Regular eye examinations are important to monitor the effectiveness of the medication and to check for any side effects or complications.
  • Contact Lenses: If you wear contact lenses, remove them before applying dipivefrin eye drops. You can reinsert them 15 minutes after applying the drops.
  • Potential Side Effects: Be aware of potential side effects such as eye irritation, burning, stinging, redness, or blurred vision. If any of these symptoms persist or worsen, contact your doctor promptly.
  • Medical Conditions: Inform your doctor of any medical conditions you have, especially cardiovascular diseases like high blood pressure or heart disease, as well as any allergies you may have.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using dipivefrin with your doctor.
  • Other Medications: Inform your doctor of any other medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements, as they may interact with dipivefrin.

Following these precautions and discussing any concerns with your doctor will help ensure the safe and effective use of dipivefrin ophthalmic for your specific condition.

What special dietary instructions should I follow?

Regarding special dietary instructions for Dipivefrin Ophthalmic, there are typically no specific dietary restrictions associated with its use. However, maintaining a healthy diet that supports overall eye health, such as consuming foods rich in antioxidants, vitamins, and minerals, can complement the treatment of eye conditions like glaucoma.

What should I do if I forget a dose?

If you forget to use a dose of Dipivefrin Ophthalmic, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. If you are unsure about what to do, consult your doctor or pharmacist for guidance.

What side effects can this medication cause?

Dipivefrin ophthalmic, like any medication, can cause side effects, although not everyone will experience them. Some common side effects of dipivefrin ophthalmic may include:

  • Eye Irritation: This can manifest as stinging, burning, itching, or redness in the eyes.
  • Blurred Vision: Some individuals may experience temporary blurred vision after using dipivefrin eye drops.
  • Increased Sensitivity to Light: Some people may become more sensitive to light (photophobia) while using this medication.
  • Eye Discomfort: This can include feelings of discomfort or foreign body sensation in the eye.
  • Eye Redness: The whites of the eyes may appear red or bloodshot.
  • Tearing: Increased tearing or watery eyes can occur as a side effect.
  • Headache: Some individuals may experience headaches after using dipivefrin eye drops.
  • Changes in Eyelash Growth: Long-term use of dipivefrin may cause changes in eyelash growth, such as increased length, thickness, or number of eyelashes.
  • Systemic Effects: Although less common, systemic side effects such as high blood pressure, rapid heart rate (tachycardia), or allergic reactions may occur.
  • Other: In rare cases, dipivefrin ophthalmic can lead to more serious side effects such as eye pain, swelling of the eyelids, or changes in vision.

If you experience any of these side effects and they persist or worsen, or if you notice any other unusual symptoms, it’s important to contact your doctor or healthcare provider promptly. They can provide guidance on how to manage these side effects and determine if any further action is needed.

It’s worth noting that this list may not include all possible side effects of dipivefrin ophthalmic. Some individuals may experience side effects not listed here. If you have any concerns about the side effects of this medication, talk to your doctor or pharmacist.

What should I know about storage and disposal of this medication?

Storage and disposal of Dipivefrin Ophthalmic:


  • Store Dipivefrin Ophthalmic eye drops at room temperature, away from moisture and heat.
  • Keep the bottle tightly closed when not in use.
  • Do not freeze the medication.
  • Keep it out of reach of children and pets.


  • Dispose of any unused or expired Dipivefrin Ophthalmic eye drops according to local regulations or guidelines.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
  • You can check with your pharmacist or local waste disposal company for proper disposal methods.

In case of emergency/overdose

  • In case of accidental ingestion of Dipivefrin Ophthalmic or if you suspect an overdose, seek emergency medical attention or contact your local poison control center immediately.
  • Overdose symptoms may include increased blood pressure, rapid heart rate, headache, sweating, and tremors.

What other information should I know?

  • Always keep your scheduled appointments with your eye doctor for regular check-ups and monitoring of your eye condition.
  • Inform your doctor about all medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements, as they may interact with Dipivefrin Ophthalmic.
  • If you experience any changes in your vision, eye pain, or other concerning symptoms while using Dipivefrin Ophthalmic, contact your doctor promptly.
  • Do not share your medication with others, even if they have similar symptoms, as it may not be suitable for their condition.

By following these guidelines for storage, disposal, and managing emergencies or overdoses, you can ensure the safe and effective use of Dipivefrin Ophthalmic for your eye condition. If you have any further questions or concerns, don’t hesitate to consult your doctor or pharmacist for guidance.

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