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Difluprednate Ophthalmic

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Why is this medication prescribed?

After eye surgery, difluprednate ophthalmic is used to relieve pain and edoema in the eyes. The drug difluprednate ophthalmic belongs to the corticosteroid drug class. It functions by preventing the release of specific organic compounds that induce pain and edoema.

How should this medicine be used?

Difluprednate ophthalmic is available as a liquid emulsion that is applied to the eye. Typically, it is given to the injured eye(s) twice daily during the first week following surgery, then four times daily for the next two weeks. Depending on your health and how you react to treatment, your doctor may gradually reduce your dose. Use difluprednate eye drops daily at roughly the same times. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Difluprednate ophthalmic should only be used as prescribed. Use it only as directed by your doctor, neither more nor less often.

Be careful not to let the bottle tip touch your eyes, fingers, face, or any other surface while using difluprednate eye drops. Bacteria might enter the eye drops if the tip does come into contact with another surface. Using bacterially contaminated eye drops can seriously harm the eye and even result in blindness. Call your doctor or pharmacist if you believe your eye drops are tainted.

Use the eye drops as directed by these steps:

  • Use soap and water to thoroughly wash your hands.
  • Make sure the dropper tip is not broken or chipped by inspecting it.
  • Eyedrops and dropper must be kept clean; avoid contacting the dropper tip to your eye or anything else.
  • Pull your lower eyelid down to create a pocket with your index finger while cocking your head back.
  • Using your other hand, place the dropper as near to your eye as you can without touching it, tip down.
  • Place the hand’s remaining fingers to your face.
  • While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.
  • Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.
  • Place a finger on the tear duct and apply gentle pressure.
  • Wipe any excess liquid from your face with a tissue.
  • If you are to use more than one drop in the same eye, wait at least 5 minutes before instilling the next drop.
  • Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.
  • To get any medication off your hands, wash them.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using difluprednate eye drops,

  • If you have any allergies to difluprednate, other steroid medications, other drugs, or any of the ingredients in difluprednate eye drops, let your doctor and pharmacist know right away. Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Use the eyedrop medications at least 10 minutes apart if you are also using another eyedrop treatment.
  • If you currently have any kind of eye infection, let your doctor know. Very likely, your doctor will advise against using difluprednate eye drops.
  • Inform your doctor if you have the herpes simplex virus or have ever had glaucoma, a condition in which an increase in eye pressure can cause a gradual loss of vision (a virus that causes sores to form on the face, lips, genitals, and rectum and can also cause eye infections.)
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while using difluprednate eye drops.
  • If you wear contact lenses, let your doctor know. Contact lenses should not be worn while using difluprednate eye drops, according to your doctor.
  • You should be aware that using difluprednate eye drops may postpone your recovery from surgery, raise your risk of experiencing specific complications following cataract surgery, increase your risk of developing an eye infection, or exacerbate an existing infection. If your discomfort and swelling don’t go down, or if you experience any of the following signs or symptoms, you should visit a doctor very away: red, swollen, or crusty eyelids; eye redness, itching, tearing, or discharge; feeling like something is in your eye; seeing floating specks; sensitivity to light.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

As soon as you realise you missed a dose, administer it. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. Using extra eye drops to make up for a forgotten dose is not advised.

What side effects can this medication cause?

Some adverse effects may be severe. Call your doctor right away if you notice any of the following symptoms or any of those detailed in the SPECIAL PRECAUTIONS section:

  • Fuzzy vision
  • Reduction in vision
  • Observing a light or sun glare

When taken for a longer duration, difluprednate eye drops may raise the chance of getting glaucoma. Your doctor will likely check your eye pressure if you use difluprednate eye drops for more than 10 days. Discuss the dangers of using this drug with your doctor.

Further adverse effects of difluprednate eye drops are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed, in the original bottle within the protective carton, and away from children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom). Avoid freezing.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Dial 1-800-222-1222 to reach your local poison control centre if someone has ingested difluprednate eye drops. Dial 911 to reach the nearest emergency services if the sufferer has collapsed or has stopped breathing.

What other information should I know?

Keep all of your doctor’s appointments. Before and during your treatment, your doctor will likely have your eyes put through a number of examinations.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Durezol®
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