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Diflucan (Generic Fluconazole)

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Why is this medication prescribed?

Fungal infections, such as yeast infections of the vagina, mouth, throat, oesophagus (tube connecting the mouth to the stomach), abdomen (region between the chest and waist), lungs, blood, and other organs, are treated with fluconazole. Meningitis, a fungal infection of the membranes lining the brain and spine, is another condition that is treated with fluconazole. Fluconazole is also used to treat patients at risk for developing yeast infections due to chemotherapy or radiation therapy they are receiving prior to a bone marrow transplant (replacement of unhealthy spongy tissue inside the bones with healthy tissue). The antifungal triazole class includes fluconazole. It functions by inhibiting the development of infection-causing fungus.

How should this medicine be used?

Fluconazole is available as a tablet and a liquid suspension for oral use. Typically, one dose per day is given, either with or without food. Fluconazole may only need to be taken once, or it may need to be taken for a few weeks or longer. Your health and how well you respond to fluconazole will determine how long you need to receive treatment. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Fluconazole should be used as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

On the first day of your therapy, your doctor might advise you to take two doses of fluconazole. Pay close attention to these guidelines.

Before each usage, give the beverage a good shake to evenly distribute the medication.

Within the first few days of fluconazole therapy, you should start to feel better. Call your doctor if your symptoms don’t go away or get worse.

Even if you feel better, keep taking fluconazole until your doctor instructs you to stop. Without consulting your doctor, do not discontinue taking fluconazole. When you abruptly stop taking fluconazole, your infection can quickly return.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

Fluconazole is also occasionally used to treat dangerous fungal infections of the eye, skin, and nails, as well as infections of the lungs that have the potential to spread throughout the body. Fluconazole is also occasionally used to prevent fungal infections in persons who are susceptible to contracting them due to having HIV, cancer, or having undergone a transplant procedure (surgery to remove an organ and replace it with a donor or artificial organ). Discuss the potential dangers of using this medicine for your illness with your doctor.

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking fluconazole,

  • If you have an allergy to fluconazole, any other antifungal drugs like itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), or voriconazole (Vfend), any other drugs, or any of the ingredients in fluconazole tablets or suspension, let your doctor and pharmacist know right once. Get a list of the components from your pharmacist.
  • Inform your doctor if you are using erythromycin (E.E.S., E-Mycin, Erythrocin), astemizole (Hismanal), cisapride (Propulsid), pimozide (Orap), quinidine (Quinidex), or terfenadine (Seldane), which are not available in the US (not available in the US). Fluconazole shouldn’t be taken if you are on any of these medications, your doctor will likely advise you.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, herbal items, and nutritional supplements you are now taking or intend to use. Moreover, within 7 days of having fluconazole, you should inform your doctor before starting any additional prescriptions. Incorporate any of the following: Amitriptyline, Amphotericin B (Abelcet, AmBisome), Warfarin (Coumadin, Jantoven), and other anticoagulants (sometimes known as “blood thinners”); calcium channel blockers such carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), amlodipine (Norvasc, in Caduet, in Lotrel, and others), felodipine, isradipine, and nifedipine (Adalat, Afeditab, Procardia); cyclophosphamide; cyclosporine (Gengraf, Neoral, Sandimmune); celecoxib (Celebrex, in Consensi); cholesterol-lowering drugs (statins), such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), and simvastatin (Zocor, in Vytorin); celecoxib (Celebrex, in Consensi); diuretics (also known as “water pills”) include hydrochlorothiazide (Microzide, in Diovan HCT, in Tribenzor, among other medications); fentanyl (Actiq, Duragesic, Fentora, Sublimaze, Subsys, among other medications); isoniazid (Laniazid, in Rifamate, in Rifater); losartan (Cozaar, in Hyzaar); nevirapine (Viramune), methadone (Methadose), midazolam (Seizalam), and nonsteroidal anti-inflammatory medicines (NSAIDS) such ibuprofen (Advil, Motrin, and others) and naproxen (Aleve, Anaprox, Naprelan, in Treximet, in Vimovo) are examples of NSAIDS; birth control pills; oral diabetes medications like glipizide (Glucotrol), glyburide (Diabeta, Glynase), and tolbutamide; nortriptyline (Pamelor); phenytoin (Dilantin, Phenytek); prednisone (Rayos); theophylline (Elixophyllin, Theo-24, Theochron), tofacitinib (Xeljanz), triazolam (Halcion), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), saquinavir (Invirase), tacrolimus (Astagraf, Prograf), sirolimus (Rapamune); zidovudine, vinblastine, vincristine (Marqibo), vitamin A, valproic acid (Depakene, Depakote), and valproic acid (Retrovir, in Combivir, in Trizivir). Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects. Fluconazole may interact with a wide variety of medications, so be sure to let your doctor know about all of the ones you are taking, even if they are not on this list.
  • If you have or have had had cancer, AIDS, an irregular heartbeat, low blood levels of calcium, salt, magnesium, or potassium, a rare genetic disorder where the body cannot accept lactose or sucrose, heart, kidney, or liver illness, or any of these conditions, let your doctor know.
  • In particular, if you are in the first three months of your pregnancy, intend to get pregnant, or are breastfeeding, let your doctor know if you are expecting. Your doctor might advise you to use birth control to avoid getting pregnant while receiving therapy and for a week following the last dose. Call your doctor if you become pregnant while taking fluconazole. The foetus could suffer from fluconazole.
  • Be sure to inform your doctor or dentist that you are taking fluconazole if you are undergoing surgery, including dental surgery.
  • Fluconazole may trigger seizures or make you feel lightheaded, so be aware of this. Prior to understanding how this drug affects you, avoid using machinery or driving a car.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

There may be negative effects from fluconazole. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Dizziness
  • Diarrhea
  • Abdominal pain
  • Heartburn
  • Alterations in food taste

Certain adverse effects can be very harmful. Call your doctor right away or seek emergency care if you see any of the following symptoms:

  • Nausea
  • Vomiting
  • Extreme fatigue
  • Significant bruising or bleeding
  • Not enough energy
  • Reduced appetite
  • Stomach ache in the top right corner
  • Eyes or skin that have a yellow tint
  • Flu-like signs
  • Dark faeces
  • Light stools
  • Seizures
  • Rash
  • Skin that is swollen or peeling
  • Hives
  • Itching
  • Edoema of the hands, feet, ankles, lower legs, cheeks, neck, tongue, lips, and eyes
  • Breathing or swallowing challenges

Further side effects of fluconazole are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom). After 14 days, dispose of any unused liquid medication.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Hallucinations (seeing things or hearing voices that do not exist)
  • Strong concern that someone is attempting to harm you

What other information should I know?

Keep all of your appointments with your physician and the lab. To determine how you are responding to fluconazole, your doctor may request specific lab tests.

Do not share your medication with anybody else. If you have any inquiries regarding refilling your prescription, speak with your pharmacist. Call your doctor if you continue to experience infection symptoms after stopping the fluconazole.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Diflucan®
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