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Diflucan (Generic Fluconazole Injection)

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Why is this medication prescribed?

Fungal infections, such as yeast infections of the mouth, throat, oesophagus (tube leading from the mouth to the stomach), abdomen (region between the chest and waist), lungs, blood, and other organs, are treated with fluconazole injection. Meningitis, a fungal infection of the membranes lining the brain and spine, is another condition that is treated with fluconazole. Fluconazole is also used to treat patients at risk for developing yeast infections due to chemotherapy or radiation therapy they are receiving prior to a bone marrow transplant (replacement of unhealthy spongy tissue inside the bones with healthy tissue). The antifungal triazole class includes fluconazole. It functions by inhibiting the development of infection-causing fungus.

How should this medicine be used?

A needle or catheter must be inserted into your vein to administer the liquid fluconazole injection. It is often intravenously (slowly injected into a vein) given once day for up to 14 days, typically over a period of 1 to 2 hours. Depending on your illness and how well you respond to fluconazole injection, the time of your treatment will vary. How long to take fluconazole injectable is something your doctor will advise you on.

On the first day of your treatment, your doctor can advise you to provide fluconazole injection at a larger dosage. Carefully follow these instructions.

Fluconazole injections are available both in hospitals and for use at home. Do your fluconazole injection at roughly the same time each day if you are doing so at home. Ask your doctor or another healthcare professional to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Fluconazole injection should only be used as prescribed. It should not be infused more quickly than instructed, nor should you use more or less of it or more frequently than your doctor has advised.

Your doctor will demonstrate how to administer the fluconazole injection if you plan to use it at home. Be sure you comprehend these instructions, and if you have any questions, consult your health care professional. If you experience any difficulties administering fluconazole injection, consult your healthcare practitioner for advice.

Examine the solution carefully before giving the fluconazole. It should be crystal clear and devoid of any floating debris. To check for leaks, gently squeeze the bag or look at the solution container. If the solution is cloudy, includes particles, or spills from the bag or container, do not use it. Show your healthcare practitioner the broken solution while using the new one.

After the first several days of treatment with fluconazole injection, you should start to feel better. Call your doctor if your symptoms don’t go away or get worse.

Even if you feel better, keep using fluconazole injectable until your doctor instructs you to stop. Your infection can recur quickly if you stop using fluconazole injection too soon.

Other uses for this medicine

Fluconazole injection is also occasionally used to treat eye, prostate (a male reproductive organ), skin, and nail fungal infections as well as dangerous fungal infections that start in the lungs and can spread throughout the body. Moreover, fluconazole injection is occasionally used to prevent fungal infections in persons who are susceptible to contracting them due to having HIV, cancer, or having undergone a transplant procedure (surgery to remove an organ and replace it with a donor or artificial organ). The dangers of using this drug for your illness should be discussed with your doctor.

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving fluconazole injection,

  • If you have an allergy to fluconazole, any other antifungal drugs like itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), or voriconazole (Vfend), any other drugs, or any of the chemicals in fluconazole injection, let your doctor and chemist know right away. Get a list of the components from your pharmacist.
  • Inform your doctor if you are taking any of the following medications: erythromycin (E.E.S., E-Mycin, Erythrocin); astemizole (Hismanal) (not available in the US); cisapride (Propulsid) (not available in the US); pimozide (Orap), quinidine (Quinidex), or terfenadine (Seldane) (not available in the US). If you are on any of these medications, your doctor probably won’t let you have fluconazole injection.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, herbal items, and nutritional supplements you are now taking or intend to use. Moreover, within seven days of getting fluconazole, you should see your doctor before starting any additional medications. Incorporate any of the following: Amitriptyline, amphotericin B (Abelcet, AmBisome, Amphotec, Fungizone), warfarin (Coumadin, Jantoven), and anticoagulants (sometimes known as “blood thinners”); midazolam (Versed), a benzodiazepine; amlodipine (Norvasc, in Caduet, in Lotrel); felodipine (Plendil, in Lexxel); isradipine (DynaCirc); and nifedipine (Adalat, Procardia), calcium channel blockers; celecoxib (Celebrex), carbamazepine (Carbatrol, Epitol, Tegretol), statins like atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), and simvastatin (Zocor, in Simcor, in Vytorin), which decrease cholesterol; cyclosporine (Gengraf, Neoral, Sandimmune), clopidogrel (Plavix), cyclophosphamide (Cytoxan), diuretics (often known as “water pills”) such hydrochlorothiazide (HydroDIURIL, Microzide), and others; fentanyl (Actiq, Duragesic, Fentora, Sublimaze), isoniazid (INH, Nydrazid), losartan (Cozaar, in Hyzaar), methadone (Methadose), nevirapine (Viramune), non-steroidal anti-inflammatory medicines (NSAIDS) such ibuprofen (Advil, Motrin, and other brands) and naproxen (Aleve, Anaprox, Naprelan); oral contraceptives (birth control pills), oral diabetes medications such glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glycron, and others), and tolbutamide (Orinase), nortriptyline (Pamelor), and phenytoin (Dilantin, Phenytek); saquinavir (Invirase), tacrolimus (Prograf), sirolimus (Rapamune), and prednisone (Sterapred) are some examples of medications; theophylline (Elixophyllin, Theo-24, Uniphyl, among other theophylline-containing medications); tofacitinib (Xeljanz); triazolam (Halcion); valproic acid (Depakene, Depakote); vinblastine; vincristine; vitamin A; voriconazole (Vfend); and zidovudine (Retrovir). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Fluconazole injection may also interact with many other drugs, so be sure to let your doctor know about all the drugs you’re taking even those not on this list.
  • Inform your doctor if you have or have had had cancer, AIDS, an irregular heartbeat, low levels of calcium, sodium, magnesium, or potassium in your blood, or conditions affecting your heart, kidneys, or liver.
  • If you are expecting, especially if you are in the first three months of your pregnancy, planning to get pregnant, or breastfeeding, let your doctor know. Call your doctor if you fall pregnant while receiving fluconazole injectable. The foetus could suffer from fluconazole injection.
  • You should inform your doctor or dentist that you are using fluconazole injection if you are having surgery, including dental surgery.
  • Fluconazole injection may trigger seizures or make you feel queasy. Prior to understanding how this drug affects you, avoid using machinery or driving a car.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

As soon as you realise you missed a dose, administer it. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not provide a second dose.

What side effects can this medication cause?

Side effects from fluconazole injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Dizziness
  • Diarrhea
  • Abdominal pain
  • Heartburn
  • Alterations in food taste

Certain adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Nausea
  • Vomiting
  • Extreme fatigue
  • Significant bruising or bleeding
  • Not enough energy
  • Reduced appetite
  • Stomach ache in the top right corner
  • Eyes or skin that have a yellow tint
  • Flu-like signs
  • Dark faeces
  • Light stools
  • Seizures
  • Rash
  • Skin wrinkling
  • Hives
  • Itching
  • Edoema of the hands, feet, ankles, lower legs, cheeks, neck, tongue, lips, and eyes
  • Breathing or swallowing challenges

Further negative effects from fluconazole injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

The best way to preserve your medication will be advised by your doctor. Just as prescribed, only store your prescription. Be sure to know the right way to store your medications.

While not in use, keep your goods in a tidy, dry location that is out of the children’s reach. To prevent unintentional harm, your healthcare professional will instruct you on how to properly dispose of used needles, syringes, tubing, and containers.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Hallucinations (seeing things or hearing voices that do not exist)
  • Strong concern that someone is attempting to harm you

What other information should I know?

Keep all of your appointments with your physician and the lab. To determine how you are responding to fluconazole injection, your doctor may order specific lab tests.

Do not share your medication with anybody else. It’s likely that your prescription cannot be renewed. Call your doctor if, after receiving the fluconazole injection, you continue to experience signs of infection.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Diflucan®
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