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Didehydrodeoxynorvincaleukoblastine (Generic Vinorelbine Injection)

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Vinorelbine should only be administered under the direction of a physician with training in the administration of chemotherapy drugs.

In your bone marrow, vinorelbine may result in a significant drop in the quantity of blood cells. This could result in specific symptoms and raise your risk of getting a serious infection. Before and during your therapy, your doctor will request laboratory tests to determine the quantity of white blood cells in your blood. If your white blood cell count is very low, your doctor may reduce your dose, postpone, suspend, or even discontinue your treatment. Call your doctor right away if you suffer any of the following symptoms: fever, sore throat, persistent cough and congestion, or any infection-related symptoms.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to vinorelbine, your doctor will request specific lab tests.

Why is this medication prescribed?

When non-small cell lung cancer (NSCLC) has spread to neighbouring tissues or to other sections of the body, vinorelbine is used both alone and in conjunction with other drugs to treat the disease. Vinorelbine belongs to the group of drugs known as vinca alkaloids. It functions by reducing or halting the development of cancer cells within your body.

How should this medicine be used?

Vinorelbine is administered intravenously (into a vein) by a physician or nurse in a healthcare setting. Typically, it is given once per week. The length of treatment is determined by how well vinorelbine works on your body.

You should be aware that vinorelbine must only be injected into a vein. It could, however, leak into nearby tissue and cause serious harm or irritation. Your doctor or nurse will keep an eye on the region close to the injection site. Tell your doctor right once if you suffer any of the following symptoms close to the injection site: discomfort, itching, redness, swelling, swelling, blisters, or ulcers.

Other uses for this medicine

In addition, soft tissue sarcomas, cancer of the oesophagus (the tube connecting the mouth and stomach), and breast cancer are occasionally treated with vinorelbine (cancer that forms in muscles). The dangers of using this drug for your illness should be discussed with your doctor.

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving vinorelbine,

  • If you have an allergy to vinorelbine, any other drugs, or any of the ingredients in vinorelbine injection, let your doctor and pharmacist know right away. Get a list of the ingredients from your chemist.
  • Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: clarithromycin, itraconazole (Onmel, Sporanox, Tolsura), and ketoconazole are some antifungal medications; Nnefazodone, indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Technivie, Viekira), and saquinavir (Invirase) are HIV protease inhibitors. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have liver illness now or previously, let your doctor know.
  • Inform your doctor if you are expecting, intend to get pregnant, or intend to father a child. Pregnancy should not occur while you are having vinorelbine injection for you or your spouse. Before beginning therapy, you must perform a pregnancy test to ensure that you are not pregnant. Use reliable birth control while receiving treatment and for six months after the last dose, if you are a female. Use reliable birth control if you’re a man during your therapy and for three months following your last dose. While getting vinorelbine injection, notify your doctor if you or your partner become pregnant. The foetus could be harmed by vinorelbine.
  • Inform your doctor if you are nursing a baby. Breastfeeding is likely to be prohibited throughout treatment and for nine days following the last dose, according to your doctor.
  • It’s important to be aware that vinorelbine can cause constipation. While using vinorelbine, discuss with your doctor how you might prevent or cure constipation by altering your diet and using additional drugs.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?

Side effects are possible with vinorelbine. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Diarrhea
  • Reduced appetite
  • Slim down
  • Alterations in food taste
  • Mouth- and throat-related sores
  • Loss of hearing
  • Joint or muscle ache
  • Hair fall
  • Fatigue, a lack of vitality, and ill health

Some adverse effects may be severe. Get emergency medical care or call your doctor right away if you develop any of the following symptoms or any of those in the IMPORTANT WARNING section:

  • Cough, breathing issues, or other symptoms
  • Nausea, vomiting, stomach pain, and constipation
  • Uncommon bruising or bleeding
  • Hives, itchiness, rash, breathing or swallowing issues
  • Face, throat, tongue, lips, and eye swelling
  • Skin that is swollen or peeling
  • Urine that is black in colour, yellowed skin or eyes, and light-colored stool
  • Unusual bleeding or bruising
  • Numbness, tingling, sensitive skin, a diminished sensation of touch, or weakness of the muscles
  • Any indicators of illness, such as a fever, chills, sore throat, or others
  • Shortness of breath, chest pain, and bloody cough
  • Arm or leg that is red, bloated, sore, or heated

Discuss the dangers of receiving an injection of vinorelbine with your doctor.

Further negative effects of vinorelbine are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Mouth- and throat-related sores
  • Abdominal pain
  • Constipation
  • Fever, chills, a sore throat, or other symptoms of infection
  • Loss of the capacity to feel a body portion and move muscles

What other information should I know?

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Navelbine®
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