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Diclegis (Generic Doxylamine and Pyridoxine)

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Why is this medication prescribed?

Diclegis is a prescription medication used to treat nausea and vomiting during pregnancy, often referred to as morning sickness. It contains a combination of two active ingredients: doxylamine succinate, an antihistamine, and pyridoxine hydrochloride (vitamin B6).

It’s typically recommended for women whose nausea and vomiting cannot be managed through dietary changes or other non-medical interventions. Diclegis works by blocking certain neurotransmitters in the brain that are responsible for triggering nausea and vomiting.

How should this medicine be used?

Diclegis is typically taken orally as directed by a healthcare professional. The usual recommended dosage is to take two tablets at bedtime. If necessary, your doctor may adjust the dosage based on your individual needs.

It’s important to swallow the tablets whole and not crush, chew, or break them. Taking Diclegis with food may help reduce the risk of stomach upset.

If you miss a dose, you should take it as soon as you remember. However, if it is almost time for your next scheduled dose, it’s generally advised not to double up on the medication. Instead, you should continue with your regular dosing schedule.

Always follow your doctor’s instructions precisely and do not exceed the recommended dose unless instructed to do so by your healthcare provider. If you have any questions or concerns about how to use Diclegis, it’s best to consult with your healthcare provider for personalized guidance.

Other uses for this medicine

Diclegis is primarily used for the treatment of nausea and vomiting during pregnancy, particularly for the condition commonly referred to as morning sickness. However, it’s essential to note that Diclegis may have other off-label uses, as determined by healthcare providers. Off-label use refers to the prescription of a medication for a condition or in a dosage not approved by regulatory authorities but based on the healthcare provider’s judgment and assessment of the patient’s needs.

What special precautions should I follow?

Regarding special precautions for Diclegis, here are some key points to consider:

  • Pregnancy and breastfeeding: Diclegis is primarily used during pregnancy to manage nausea and vomiting, and it’s considered safe for use in pregnant women. However, as with any medication, it’s essential to discuss the potential risks and benefits with your healthcare provider before taking Diclegis during pregnancy. Additionally, it’s important to inform your healthcare provider if you are breastfeeding, as small amounts of the medication may pass into breast milk.
  • Medical history: Before taking Diclegis, inform your healthcare provider about your medical history, including any allergies, especially to antihistamines or pyridoxine (vitamin B6), as Diclegis contains both these ingredients. Also, inform them about any other medical conditions you have, such as asthma, glaucoma, urinary retention, or liver disease.
  • Other medications: Inform your healthcare provider about all the medications you are currently taking, including prescription and over-the-counter medications, vitamins, and herbal supplements. Certain medications may interact with Diclegis, potentially affecting its effectiveness or increasing the risk of side effects.
  • Driving and operating machinery: Diclegis may cause drowsiness or dizziness, especially when taken with other medications that have similar side effects. Avoid driving, operating machinery, or engaging in activities that require mental alertness until you know how Diclegis affects you.
  • Alcohol: Avoid consuming alcohol while taking Diclegis, as it may exacerbate drowsiness and dizziness.
  • Overdose: Taking more than the prescribed dose of Diclegis can lead to overdose symptoms, including severe drowsiness, hallucinations, seizures, and difficulty breathing. If you suspect an overdose, seek immediate medical attention or contact a poison control center.

Always follow your healthcare provider’s instructions and advice regarding the use of Diclegis, and do not hesitate to ask any questions or seek clarification about its use and precautions.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are generally no specific dietary restrictions associated with taking Diclegis. However, taking it with food may help reduce the risk of stomach upset. If you have any concerns about dietary considerations, discuss them with your healthcare provider.

What should I do if I forget a dose?

If you forget to take a dose of Diclegis, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If you have questions about missed doses or need guidance, consult your healthcare provider or pharmacist for advice tailored to your situation.

What side effects can this medication cause?

Diclegis is generally well-tolerated, but like any medication, it can cause side effects in some individuals. Common side effects of Diclegis may include:

  • Drowsiness: Diclegis may cause drowsiness, especially when you first start taking it or when the dosage is increased. It’s important to avoid activities that require mental alertness, such as driving or operating machinery, until you know how Diclegis affects you.
  • Dry mouth: Some people may experience dry mouth while taking Diclegis. Drinking water or chewing sugar-free gum can help alleviate this symptom.
  • Dizziness: Diclegis may cause dizziness or lightheadedness, particularly when standing up quickly from a sitting or lying position. Taking precautions such as standing up slowly can help reduce the risk of dizziness.
  • Fatigue: Feeling tired or fatigued is a common side effect of Diclegis. It’s essential to get an adequate amount of rest while taking this medication.
  • Headache: Some individuals may experience headaches while taking Diclegis. If headaches persist or become severe, consult your healthcare provider.
  • Nausea: Ironically, Diclegis, which is used to treat nausea, may occasionally cause mild nausea as a side effect. If this occurs, contact your healthcare provider for guidance.
  • Constipation: Diclegis may cause constipation in some individuals. Drinking plenty of water, eating a high-fiber diet, and staying physically active can help prevent or alleviate constipation.
  • Increased heart rate: In rare cases, Diclegis may cause an increased heart rate (tachycardia). If you experience palpitations, rapid heartbeat, or other cardiac symptoms, seek medical attention promptly.
  • Allergic reactions: Although rare, some people may experience allergic reactions to Diclegis. Symptoms of an allergic reaction may include rash, itching, swelling, dizziness, or difficulty breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.

It’s important to note that not everyone will experience side effects while taking Diclegis, and many people tolerate the medication well. If you have concerns about potential side effects or experience any unusual symptoms while taking Diclegis, contact your healthcare provider for further evaluation and guidance.

What should I know about storage and disposal of this medication?

Storage and disposal of Diclegis:


  • Store Diclegis at room temperature away from moisture, heat, and light.
  • Keep it out of reach of children and pets.
  • Do not store Diclegis in the bathroom or near the kitchen sink, where it might get wet.


  • Dispose of any unused or expired Diclegis tablets properly according to local guidelines or medication take-back programs.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so by your healthcare provider or pharmacist.

In case of emergency/overdose

  • In case of an emergency or suspected overdose, such as taking more than the prescribed dose of Diclegis, contact your local poison control center (1-800-222-1222 in the United States) or seek emergency medical attention immediately.
  • Be prepared to provide information about the amount of Diclegis ingested, as well as any symptoms experienced.

What other information should I know?

  • Inform all healthcare providers involved in your care that you are taking Diclegis, including dentists, surgeons, and emergency medical personnel.
  • Attend all scheduled appointments with your healthcare provider to monitor your response to Diclegis and discuss any concerns or changes in your condition.
  • Do not share Diclegis with others, even if they have similar symptoms. It is prescribed based on individual needs and medical history.
  • Follow your healthcare provider’s instructions regarding any dietary restrictions, lifestyle modifications, or additional medications to ensure the most effective treatment plan.

It’s essential to have a comprehensive understanding of how to store, dispose of, and handle emergencies related to Diclegis to ensure safe and effective use of the medication. If you have any questions or concerns about Diclegis, don’t hesitate to consult your healthcare provider or pharmacist for further guidance.

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