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Dibenzyline (Generic Phenoxybenzamine)

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Why is this medication prescribed?

Dibenzyline is primarily prescribed to treat certain conditions like pheochromocytoma, a tumor of the adrenal gland, and to manage high blood pressure (hypertension) caused by such tumors. It works by blocking the action of adrenaline, which helps to reduce blood pressure and other symptoms associated with these conditions.

How should this medicine be used?

When using Dibenzyline, it’s crucial to follow your doctor’s instructions carefully. Typically, it’s taken orally, usually two to three times a day. The dosage can vary based on your medical condition and response to treatment. It’s essential to take it consistently and at the same times each day for the best results.

Since Dibenzyline can cause dizziness or drowsiness, especially when you first start taking it or when the dosage is increased, it’s essential to avoid activities requiring alertness, such as driving or operating machinery, until you know how this medication affects you. Also, avoid consuming alcohol while taking Dibenzyline, as it can worsen these side effects.

Never stop taking Dibenzyline abruptly without consulting your doctor, as it can lead to a rapid increase in blood pressure. If you have any concerns or experience any side effects while taking Dibenzyline, be sure to discuss them with your healthcare provider.

Other uses for this medicine

Dibenzyline may sometimes be prescribed for other conditions or off-label uses, such as Raynaud’s disease, a condition where certain parts of the body—usually the fingers and toes, feel numb and cold in response to cold temperatures or stress. However, the use of Dibenzyline for such conditions should be determined by your doctor based on your individual medical needs.

What special precautions should I follow?

When taking Dibenzyline, it’s crucial to follow some special precautions to ensure safe and effective treatment:

  • Medical History: Inform your doctor about your complete medical history, especially if you have any allergies, heart problems, kidney disease, liver disease, or a history of mental/mood disorders.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Dibenzyline with your doctor. It’s essential to weigh the potential risks to the unborn baby or nursing infant against the benefits of treatment.
  • Interactions: Inform your doctor about all the medications, supplements, and herbal products you are currently taking, as Dibenzyline may interact with certain drugs, including other blood pressure medications, antidepressants, and drugs for erectile dysfunction.
  • Blood Pressure Monitoring: Your doctor will regularly monitor your blood pressure and may adjust your dosage of Dibenzyline accordingly to achieve optimal blood pressure control.
  • Avoid Certain Activities: Due to the potential for dizziness or drowsiness, avoid activities requiring mental alertness or coordination, such as driving or operating machinery, until you know how Dibenzyline affects you.
  • Alcohol and Other Substances: Avoid consuming alcohol while taking Dibenzyline, as it can worsen dizziness and drowsiness. Also, be cautious when using marijuana or other substances that may affect your alertness or coordination.
  • Emergency Situations: In case of emergency situations such as surgery, inform healthcare providers that you are taking Dibenzyline, as it may interact with certain anesthetics and other medications used during surgical procedures.

Always follow your doctor’s advice and recommendations closely when taking Dibenzyline to ensure safe and effective treatment. If you have any questions or concerns, don’t hesitate to discuss them with your healthcare provider.

What special dietary instructions should I follow?

Regarding special dietary instructions for Dibenzyline, there are no specific dietary restrictions associated with its use. However, it’s generally recommended to follow a balanced and healthy diet low in sodium and saturated fats to help manage high blood pressure.

What should I do if I forget a dose?

If you forget to take a dose of Dibenzyline, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you’re unsure about what to do, consult your doctor or pharmacist for guidance.

What side effects can this medication cause?

Dibenzyline, like any medication, can cause side effects, although not everyone will experience them. Common side effects of Dibenzyline may include:

  • Dizziness
  • Drowsiness
  • Weakness
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Constipation
  • Dry mouth
  • Blurred vision
  • Loss of appetite
  • Weight gain
  • Swelling of the ankles or feet
  • Increased sensitivity to light

Serious side effects are rare but can occur. Seek immediate medical attention if you experience any of the following:

  • Fainting
  • Severe dizziness or lightheadedness
  • Fast or irregular heartbeat
  • Mental/mood changes (e.g., confusion, hallucinations)
  • Difficulty urinating
  • Persistent or severe headache
  • Signs of an allergic reaction, such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing

It’s essential to report any side effects you experience while taking Dibenzyline to your doctor promptly. They can help determine whether any adjustments need to be made to your treatment plan to minimize side effects and ensure your safety.

What should I know about storage and disposal of this medication?

Storage and disposal of Penicillin G Dibenzyline:


  • Store Dibenzyline at room temperature away from light and moisture.
  • Keep it out of reach of children and pets.
  • Do not store it in the bathroom or near the kitchen sink where it might get wet.
  • Check the expiration date on the label and discard any expired medication.


  • Dispose of unused or expired Dibenzyline properly according to local guidelines or take-back programs.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
  • If you’re unsure how to dispose of Dibenzyline safely, consult your pharmacist or local waste disposal facility.

In case of emergency/overdose

  • In case of an overdose, contact your local poison control center at 1-800-222-1222 or go to the nearest emergency room immediately.
  • Symptoms of overdose may include severe dizziness, fainting, fast or irregular heartbeat, confusion, hallucinations, difficulty breathing, and seizures.
  • Do not induce vomiting unless instructed by medical personnel.

What other information should I know?

  • Keep all appointments with your doctor and laboratory tests while taking Dibenzyline to monitor your response to treatment and check for side effects.
  • Inform all healthcare providers involved in your care that you are taking Dibenzyline, especially before any surgical procedures.
  • Avoid sudden changes in posture, such as standing up quickly from a lying or sitting position, as Dibenzyline may cause dizziness or lightheadedness.
  • Do not stop taking Dibenzyline without consulting your doctor, even if you feel well, as suddenly stopping this medication may cause a rapid increase in blood pressure.
  • Carry identification or wear a medical alert bracelet to inform others that you are taking Dibenzyline in case of emergencies.

Following these guidelines will help ensure the safe and effective use of Dibenzyline and minimize any risks associated with its use. If you have any questions or concerns about your medication, don’t hesitate to discuss them with your healthcare provider or pharmacist.

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