Use of diazepam rectal in combination with other drugs may increase the risk of serious or life-threatening respiratory issues, drowsiness, or coma. Inform your physician if you are currently taking or intend to take any opiate medications, including codeine (in Triacin-C, Tuzistra XR) or hydrocodone (in Anexsia, Norco, or Zyfrel) for coughing or codeine (in Fiorinal) for pain. Other opiate medications include fentanyl (Actiq, Duragesic, Subsys), hydromorphone (Dilaudid, Exalgo) (Conzip, Ultram, in Ultracet). The dosages of your medications may need to be adjusted, and your doctor will closely monitor you. Diazepam rectal users should call their doctors right away or seek emergency medical attention right away if they experience any of the following symptoms while taking any of these medications: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Make sure your carer or family members are aware of any symptoms that could be significant so they can contact an emergency room or a doctor if you are unable to do so on your own.

Rectal benzodiazepines may lead to addiction. Never exceed the recommended dosage, frequency, or duration. Always follow your doctor’s instructions. Inform your doctor if you use or have ever used illicit drugs, consumed excessive amounts of alcohol, or have ever misused any prescription drugs. Don’t consume alcohol or use illicit substances while receiving treatment. Using illicit substances or alcohol while receiving treatment with diazepam also increases your risk of developing these severe, sometimes fatal adverse effects. Additionally let your doctor know if you suffer from depression or any other mental disease now or in the past.

When used for several days to weeks, diazepam rectal can lead to physical dependency, a condition in which unpleasant physical symptoms appear if a medicine is abruptly stopped or taken in lesser dosages. Without consulting your doctor, do not reduce the dosage or stop taking this drug. Diazepam rectal withdrawal symptoms might exacerbate your health and last anywhere from a few weeks to more than a year if you suddenly stop taking it. Your doctor will probably progressively reduce the amount of diazepam rectal you take. If you encounter any of the following symptoms, call your doctor or seek emergency medical attention: Unusual movements, ringing in the ears, anxiety, memory issues, difficulty concentrating, sleep issues, seizures, shaking, muscle twitching, changes in mental health, depression, burning or prickling sensations in the hands, arms, legs, or feet, seeing or hearing things that others do not see or hear, suicidal thoughts, excessive excitement, or losing touch with reality are all signs that something is wrong.

Those who are taking different medications to manage their epilepsy can take diazepam rectal gel in emergency settings to stop cluster seizures (episodes of heightened seizure activity). Diazepam belongs to the group of drugs known as benzodiazepines. It’s a good idea to have a backup plan in case the main one fails.

Diazepam is available as a gel that must be injected intravenously using a prefilled syringe with a unique plastic tip. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following.

The doctor will explain to your carer how to spot the warning signals of the kind of seizure activity that should be treated with this medication before prescribing diazepam rectal gel. Moreover, your carer will learn how to apply the rectal gel.

Rectal gel for benzodiazepines should not be used every day. Use of diazepam rectal gel shouldn’t exceed five times per month or more frequently than once every five days. Talk to your doctor if you or your carer believe you require more frequent application of diazepam rectal gel.

• Place the seizure sufferer on his or her side in a secure location so that they cannot fall.
• Push the protective cover up with your thumb and then peel it off the syringe to remove it.
• On the rectal tip, apply lubricant.
• Bend the person’s upper leg forward while they are lying on their side with their back to you, then separate their buttocks to reveal the rectum.
• Carefully slide the syringe tip into the rectum until the rim is snug against the rectal aperture.
• Push the plunger in until it stops while slowly counting to three.
• Recount the number 3 slowly before removing the syringe from the rectum.
• Keep the buttocks together tightly to prevent gel leakage from the rectum. Count to three carefully before releasing.
• Remain by the other person’s side. Keep an eye on the person and note the time the diazepam rectal gel was administered.
• Remove the plunger from the syringe body and point the tip over a sink or toilet to get rid of any leftover diazepam gel. To release the drug into the toilet or sink, insert the plunger into the syringe and gently push it. When the diazepam gel is no longer visible, flush the toilet or fill the sink with water. Put all used materials away from children and pets in the garbage.
• Upon administration of diazepam rectal gel (or as directed by the doctor), seizures last for 15 minutes.
• the seizures seem unusual or worse than usual.
• You are concerned about how frequently seizures occur.
• You are concerned about the seizure sufferer’s skin tone or respiration.
• The person is experiencing uncommon or significant issues.

For a copy of the manufacturer’s administration instructions, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before using diazepam rectal gel,

• If you have any allergies, including to any of the ingredients in diazepam rectal, inform your doctor and pharmacist right away. Get a list of the components from your pharmacist.
• Inform your doctor and pharmacist about any vitamins, nutritional supplements, and prescription and over-the-counter drugs you are now taking or intend to take. Any of the following should be mentioned: cimetidine (Tagamet); anticoagulants (blood thinners) like warfarin (Coumadin, Jantoven); antidepressants (‘mood lifters’) like imipramine (Surmontil, Tofranil); antihistamines; carbamazepine (Carbatrol, Epitol, Tegretol); some antifungals like clotrimazole (Lotrimin), fluconazole (Diflucan), dexamethasone, cyclosporine (Gengraf, Neoral, Sandimmune), and drugs for nausea, anxiety, or mental disease; monoamine oxidase (MAO) inhibitors, such as tranylcypromine (Parnate), isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and phenelzine; rifampin (Rifadin, Rimactane, in Rifamate), quinidine (in Nuedexta), phenobarbital (Abraxane, Taxol), phenytoin (Dilantin, Phenytek), propranolol (Hemangeol, Inderal, Innopran), paclitaxel (Abraxane, Taxol), phenytoin (Dilantin, Phenytek); sedatives, sleeping medications, troleandomycin, theophylline (Elixophyllin, Theo-24, Theochron), and tranquillizers (no longer available in the U.S.; TAO). Diazepam rectal may interact with a wide variety of other drugs, so be careful to inform your doctor about all the drugs you are taking, even if they do not appear on this list. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• In particular, mention St. John’s wort to your doctor when you use any herbal remedies.
• If you have glaucoma, lung conditions including asthma or pneumonia, liver or renal illness, or if you have ever had any of these conditions, let your doctor know.
• Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while using diazepam rectal gel.
• If you are 65 years of age or older, discuss the advantages and disadvantages of using diazepam rectal gel with your doctor. As diazepam rectal gel is less safe than other drugs that can be used to treat the same illness, older persons should often avoid using it.
• You must to be aware that benzodiazepine rectal gel might make you sleepy. Driving, operating machinery, or cycling should all be avoided until diazepam rectal gel’s effects have worn off.

If you plan to consume grapefruits or grapefruit juice while taking this medication, consult your doctor.

Side effects from diazepam rectal gel are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Drowsiness
• Dizziness
• Headache
• Pain
• Abdominal pain
• Nervousness
• Flushing
• Diarrhea
• Unsteadiness
• Unusually “high” feeling
• Inadequate coordination
• Clogged nose
• Difficulties sleeping or staying asleep

Some adverse effects may be severe. Call your doctor right away or seek emergency medical attention if any of the following symptoms occur, in addition to those in the IMPORTANT WARNING section:

• Rash
• Difficulty breathing
• Rage

Further negative effects of diazepam rectal gel could exist. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at ambient temperature and away from excess heat and moisture (not in the bathroom). See your pharmacist for advice on how to properly dispose of your medications.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

• Drowsiness
• Confusion
• Coma
• Sluggish reactions

Keep all of your doctor’s appointments. To determine whether your dose of diazepam rectal needs to be adjusted, your doctor will need to see you every six months.

You or your carer should call your doctor right away if you experience symptoms that are different from your typical seizure patterns.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every drug you take, including prescription and nonprescription (over-the-counter) medications, vitamins, minerals, and other dietary supplements. Every time you see a doctor or are admitted to the hospital, you should carry this list with you. Also, it is crucial to have this knowledge on hand in case of emergency.