WARNING

Desyrel, also known as trazodone, is primarily prescribed to treat depression, anxiety disorders, and insomnia. While it can be effective for many people, there are risks associated with its use. Some common risks include:

• Sedation: Desyrel can cause significant drowsiness, especially when starting treatment or when the dosage is increased. This can impair your ability to drive or operate machinery safely.
• Orthostatic Hypotension: Desyrel may lead to a drop in blood pressure upon standing up, which can cause dizziness or fainting.
• Serotonin Syndrome: In rare cases, taking Desyrel with other medications that affect serotonin levels can lead to a potentially life-threatening condition called serotonin syndrome. Symptoms include agitation, hallucinations, fast heart rate, fever, sweating, shivering, trembling, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
• Priapism: Another rare but serious side effect of Desyrel is priapism, a prolonged and painful erection unrelated to sexual stimulation. If not treated promptly, priapism can cause permanent damage to the penis.
• Suicidal Thoughts: Like many antidepressants, Desyrel carries a warning about an increased risk of suicidal thoughts or behaviors, especially in young adults under the age of 24.
• Withdrawal Symptoms: Suddenly stopping Desyrel can cause withdrawal symptoms such as anxiety, agitation, irritability, insomnia, confusion, dizziness, numbness or tingling sensations, headache, nausea, vomiting, diarrhea, sweating, tremors, and flu-like symptoms.

It’s crucial to discuss the potential risks and benefits of Desyrel with your healthcare provider before starting or discontinuing treatment. They can help you weigh the risks against the potential benefits and develop a treatment plan that’s right for you.

Why is this medication prescribed?

Desyrel, also known as trazodone, is prescribed primarily for the treatment of major depressive disorder (MDD). It belongs to a class of medications called serotonin antagonist and reuptake inhibitors (SARIs), which work by increasing the levels of serotonin in the brain.

In addition to depression, Desyrel may also be used off-label to treat anxiety disorders, insomnia, and certain types of chronic pain.

How should this medicine be used?

Desyrel is usually taken orally, typically once daily at bedtime to minimize daytime drowsiness. The dosage prescribed will vary depending on the individual’s condition, medical history, and response to treatment. It’s important to take Desyrel exactly as prescribed by your healthcare provider, even if you start to feel better.

The tablets should be swallowed whole with a full glass of water, and it’s generally recommended to avoid alcohol and grapefruit juice while taking Desyrel, as they can increase the risk of side effects.

It may take several weeks for Desyrel to exert its full therapeutic effects, so it’s important to continue taking it as directed, even if you don’t notice immediate improvements. However, if you experience any bothersome side effects or worsening symptoms, it’s crucial to notify your healthcare provider promptly. They can adjust your dosage or prescribe alternative treatments as needed.

Other uses for this medicine

In addition to its primary use in treating major depressive disorder (MDD), Desyrel (trazodone) is sometimes prescribed off-label for various other conditions. These may include:

• Anxiety disorders: Desyrel may be used to manage symptoms of anxiety disorders such as generalized anxiety disorder (GAD) or panic disorder.
• Insomnia: Due to its sedative properties, Desyrel is sometimes prescribed off-label to help with sleep difficulties, particularly insomnia.
• Chronic pain: In some cases, Desyrel may be used to help alleviate certain types of chronic pain, such as neuropathic pain or fibromyalgia.

What special precautions should I follow?

As for special precautions when taking Desyrel, here are some key considerations:

• Suicidal thoughts: Like many antidepressants, Desyrel carries a warning about the increased risk of suicidal thoughts, particularly in young adults and adolescents. Patients, especially those under 24 years old, should be closely monitored for any changes in mood or behavior when starting or adjusting the dosage of Desyrel.
• Serotonin syndrome: Desyrel can increase serotonin levels in the brain, which may lead to serotonin syndrome, a potentially life-threatening condition characterized by symptoms such as agitation, hallucinations, rapid heartbeat, fever, sweating, shivering, trembling, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. This risk is increased when Desyrel is taken with other medications that also affect serotonin levels. Inform your doctor about all medications, supplements, and herbal products you’re taking to avoid potential interactions.
• Allergic reactions: Some individuals may experience allergic reactions to Desyrel, characterized by symptoms such as rash, itching, swelling, severe dizziness, or trouble breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Other medical conditions: Inform your healthcare provider about any pre-existing medical conditions you have, especially if you have a history of heart disease, liver disease, kidney disease, bipolar disorder, seizures, or a recent heart attack. Adjustments to your Desyrel dosage or additional monitoring may be necessary in these cases.

Always follow your doctor’s instructions carefully when taking Desyrel and report any concerning symptoms or side effects promptly.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Desyrel. However, it’s generally recommended to avoid consuming alcohol and grapefruit juice while taking Desyrel, as they can increase the risk of side effects or interactions.

What should I do if I forget a dose?

If you miss a dose of Desyrel, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Desyrel (trazodone) can cause various side effects, ranging from mild to severe. Common side effects may include:

• Drowsiness: Desyrel is known for its sedative effect, which can cause drowsiness and fatigue. It’s often taken at bedtime to help manage this side effect.
• Dizziness: Some individuals may experience dizziness or lightheadedness, especially when standing up quickly from a sitting or lying position.
• Dry mouth: Desyrel can lead to a dry mouth sensation, which may be bothersome for some people.
• Blurred vision: Vision may become temporarily blurry while taking Desyrel.
• Constipation or diarrhea: Changes in bowel habits, such as constipation or diarrhea, can occur in some individuals.
• Nausea or vomiting: Desyrel may cause gastrointestinal upset, including nausea and vomiting, particularly when starting treatment.
• Headache: Some individuals may experience headaches while taking Desyrel.
• Weight changes: Desyrel can sometimes lead to weight gain or weight loss, although these effects are less common.

Less common but potentially serious side effects of Desyrel include:

• Serotonin syndrome: This is a rare but potentially life-threatening condition that can occur when there is an excessive accumulation of serotonin in the body. Symptoms may include agitation, hallucinations, rapid heartbeat, fever, sweating, shivering, trembling, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
• Allergic reactions: Some individuals may experience allergic reactions to Desyrel, characterized by symptoms such as rash, itching, swelling, severe dizziness, or trouble breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Changes in mood or behavior: Desyrel, like other antidepressants, may increase the risk of suicidal thoughts or behavior, especially in young adults and adolescents. It’s essential to monitor for any changes in mood or behavior and seek medical attention if needed.

If you experience any side effects while taking Desyrel, it’s important to discuss them with your healthcare provider. They can provide guidance on managing side effects and may adjust your dosage or prescribe alternative treatments if necessary.

What should I know about storage and disposal of this medication?

When it comes to storage and disposal of Desyrel (trazodone), it’s essential to follow these guidelines:

Storage:

• Store Desyrel at room temperature, away from moisture and heat.
• Keep Desyrel out of reach of children and pets.
• Store Desyrel in its original container, tightly closed, and away from light.

Disposal:

• Do not keep outdated or unused medication. Dispose of any unused Desyrel properly.
• Follow any specific disposal instructions provided by your healthcare provider or pharmacist.
• Do not flush Desyrel down the toilet unless instructed to do so. Instead, dispose of it in a sealed container with coffee grounds or cat litter and throw it in the trash.
• You can also inquire with your local pharmacy or waste management facility about medication take-back programs in your area.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms after taking Desyrel, such as fainting, irregular heartbeat, difficulty breathing, or loss of consciousness, seek immediate medical attention. You can also contact your local poison control center at 1-800-222-1222 (in the United States) for assistance.

What other information should I know?

• Desyrel may interact with other medications, including prescription drugs, over-the-counter medicines, and herbal supplements. Inform your healthcare provider about all medications you are taking to avoid potential interactions.
• Avoid consuming alcohol while taking Desyrel, as it can increase the risk of side effects such as drowsiness and dizziness.
• Desyrel may impair your ability to drive or operate machinery safely, especially when you first start taking it. Avoid these activities until you know how Desyrel affects you.
• Do not stop taking Desyrel suddenly without consulting your healthcare provider, as this may lead to withdrawal symptoms. Your doctor may need to taper your dosage gradually to avoid withdrawal effects.
• Attend all scheduled appointments with your healthcare provider for monitoring and evaluation of your treatment progress.
• Keep a list of all medications you are taking, including Desyrel, and carry it with you in case of emergencies.

By following these guidelines and staying informed about Desyrel, you can use the medication safely and effectively as prescribed by your healthcare provider. If you have any questions or concerns, don’t hesitate to discuss them with your doctor or pharmacist.