PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Despec NR (Generic Phenylephrine)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.

Why is this medication prescribed?

Despec NR is commonly prescribed for symptomatic relief of cough associated with upper respiratory tract infections and allergies. Let’s break down the components and their purposes:

  • Dextromethorphan: This is a cough suppressant that works by suppressing the cough reflex in the brain. It helps to reduce the urge to cough.
  • Guaifenesin: This is an expectorant that helps to thin and loosen mucus in the airways, making it easier to cough up and clear the air passages.
  • Phenylephrine: This is a decongestant that constricts blood vessels in the nasal passages, reducing swelling and congestion, which can help alleviate symptoms like a stuffy or runny nose.

How should this medicine be used?

Despec NR is typically taken orally, in the form of tablets, capsules, or syrup. Here’s a general guideline on how it should be used:

  • Follow the instructions provided by your healthcare provider or those on the medication label carefully. This includes dosage, frequency, and duration of use.
  • If you are taking Despec NR in tablet or capsule form, swallow it whole with a full glass of water. Do not crush or chew extended-release tablets or capsules, as it may lead to an overdose of the medication.
  • If you are using Despec NR syrup, use the provided measuring device to ensure you are taking the correct dosage. Shake the bottle well before each use.
  • Despec NR is typically taken every 4 to 6 hours as needed for symptom relief. However, it’s essential to follow the specific dosing instructions provided to you, as they may vary depending on factors such as age, weight, and the severity of your symptoms.
  • Do not exceed the recommended dosage or take Despec NR for longer than prescribed. Taking too much can lead to adverse effects and complications.
  • Avoid taking other medications that contain similar ingredients while using Despec NR, as it may result in an accidental overdose.
  • If your symptoms persist or worsen despite taking Despec NR, consult your healthcare provider for further evaluation and advice.

Always store Despec NR according to the instructions on the packaging, and keep it out of reach of children. If you have any questions or concerns about how to use Despec NR, don’t hesitate to consult your healthcare provider or pharmacist for clarification.

Other uses for this medicine

Despec NR is primarily prescribed for cough relief associated with upper respiratory tract infections and allergies due to its combination of dextromethorphan (a cough suppressant), guaifenesin (an expectorant), and phenylephrine (a decongestant). However, it’s important to note that Despec NR should only be used for its intended purpose as directed by a healthcare provider. Using it for other purposes without medical guidance can be unsafe and ineffective.

What special precautions should I follow?

As for special precautions to follow when using Despec NR:

  • Medical History: Inform your healthcare provider about your complete medical history, especially if you have any pre-existing conditions such as high blood pressure, heart disease, thyroid problems, diabetes, glaucoma, liver disease, kidney disease, or prostate enlargement. These conditions may affect how Despec NR works for you or whether it’s safe for you to use.
  • Allergies: Tell your doctor if you have any allergies to dextromethorphan, guaifenesin, phenylephrine, or any other medications. Despec NR may contain inactive ingredients that can cause allergic reactions or other problems.
  • Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, consult your healthcare provider before using Despec NR. It’s essential to weigh the potential risks and benefits under these circumstances.
  • Children and Elderly: Use caution when giving Despec NR to children or elderly individuals, as they may be more sensitive to its effects or may require adjusted dosages.
  • Drug Interactions: Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Some medications may interact with Despec NR, potentially affecting its effectiveness or increasing the risk of side effects.
  • Driving and Operating Machinery: Despec NR may cause dizziness or drowsiness, especially at higher doses. Use caution when driving, operating machinery, or performing tasks that require mental alertness until you know how Despec NR affects you.
  • Alcohol: Avoid consuming alcohol while taking Despec NR, as it may increase the risk of side effects such as dizziness and drowsiness.
  • Overdose: Taking more than the recommended dosage of Despec NR can lead to overdose and serious health consequences. Seek medical attention immediately if you suspect an overdose, or if you experience symptoms such as severe dizziness, confusion, hallucinations, rapid heartbeat, difficulty breathing, or seizures.

Always follow your healthcare provider’s instructions and guidelines when using Despec NR, and consult them if you have any questions or concerns about its use or precautions.

What special dietary instructions should I follow?

Special dietary instructions for Despec NR typically involve maintaining adequate hydration, especially when taking the medication in syrup form. Drinking plenty of fluids helps to keep mucus thin and facilitates its removal from the respiratory tract.

What should I do if I forget a dose?

If you forget a dose of Despec NR, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Despec NR, like any medication, can cause side effects, although not everyone may experience them. Common side effects may include:

  • Drowsiness or dizziness: Phenylephrine, one of the components of Despec NR, can cause these effects, particularly at higher doses.
  • Nausea or upset stomach: Guaifenesin, an expectorant in Despec NR, may cause gastrointestinal discomfort in some individuals.
  • Headache: This is a possible side effect of Despec NR, though it’s not very common.
  • Dry mouth or throat: Dextromethorphan, the cough suppressant in Despec NR, may cause dryness in the mouth or throat.
  • Difficulty sleeping (insomnia): This side effect is more likely if Despec NR is taken close to bedtime, especially due to the presence of dextromethorphan.
  • Increased heart rate or palpitations: Phenylephrine can occasionally cause these cardiovascular side effects.
  • Nervousness or restlessness: Some individuals may experience jitteriness or agitation, which can be associated with phenylephrine.
  • Allergic reactions: While rare, some people may experience allergic reactions to Despec NR, such as rash, itching, swelling, or difficulty breathing. Seek medical attention immediately if you experience any signs of an allergic reaction.
  • High blood pressure: Phenylephrine, particularly in higher doses, can elevate blood pressure in some individuals, especially those with hypertension or cardiovascular issues.

It’s important to note that this is not a comprehensive list of side effects, and other adverse reactions may occur. If you experience any unusual or severe side effects while taking Despec NR, contact your healthcare provider promptly. Additionally, if you have concerns about potential side effects, discuss them with your doctor or pharmacist before starting Despec NR.

What should I know about storage and disposal of this medication?

When it comes to storage and disposal of Despec NR:


  • Store Despec NR at room temperature away from light and moisture.
  • Keep it out of reach of children and pets.
  • Do not store Despec NR in the bathroom or near the kitchen sink, where it might be exposed to moisture.
  • Follow any specific storage instructions provided on the medication packaging.


  • Dispose of expired or unused Despec NR properly according to local regulations or guidelines.
  • Do not flush medications down the toilet unless instructed to do so.
  • Consult your pharmacist or local waste disposal authority for information on how to safely dispose of Despec NR.

In case of emergency/overdose

  • If you suspect an overdose of Despec NR, or if someone has accidentally ingested it, seek medical attention immediately.
  • Call your local poison control center or emergency services for guidance.
  • Symptoms of overdose may include severe dizziness, confusion, hallucinations, rapid heartbeat, difficulty breathing, or seizures.

What other information should I know?

  • Keep track of your dosage schedule and follow it as prescribed by your healthcare provider.
  • Do not take Despec NR for longer than recommended or in higher doses than prescribed.
  • Avoid consuming alcohol while taking Despec NR, as it may increase the risk of side effects.
  • Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Despec NR.
  • If your symptoms persist or worsen despite taking Despec NR, consult your healthcare provider for further evaluation and guidance.

Following these guidelines can help ensure the safe and effective use of Despec NR. If you have any questions or concerns about Despec NR, its storage, disposal, or usage, consult your healthcare provider or pharmacist for clarification.

Copyright © 2023