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Descarboethoxyloratadine (Generic Desloratadine)

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Why is this medication prescribed?

Desloratadine is a medication primarily prescribed to relieve symptoms associated with allergies, such as hay fever (allergic rhinitis) and hives (chronic idiopathic urticaria). It belongs to a class of medications known as antihistamines, which work by blocking the action of histamine, a substance in the body that causes allergy symptoms.

How should this medicine be used?

Desloratadine is an antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itching, and watery eyes. It comes in tablet, rapidly disintegrating tablet, and syrup forms. Here’s how it’s typically used:

  • Follow the Instructions: Always follow the instructions provided by your doctor or pharmacist. Do not exceed the recommended dosage.
  • Dosage: The typical dosage for adults and children over 12 years old is 5 milligrams once a day. For children aged 6 to 11 years old, the dose is usually 2.5 milligrams once daily.
  • Administration: Desloratadine tablets should be swallowed whole with water. The rapidly disintegrating tablets should be placed on the tongue and allowed to dissolve before swallowing. The syrup should be measured with a dose-measuring spoon, oral syringe, or medicine cup.
  • Timing: It can be taken with or without food. However, it’s best to take it at the same time each day to maintain a consistent level of the medication in your bloodstream.
  • Duration: Continue taking Desloratadine for as long as directed by your doctor, even if your symptoms improve. Do not stop taking it without consulting your doctor.
  • Missed Dose: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
  • Storage: Store Desloratadine tablets and syrup at room temperature away from moisture and heat. Keep the medication out of reach of children.
  • Precautions: Inform your doctor if you have any allergies, liver disease, kidney disease, or any other medical conditions before starting Desloratadine. Also, let them know about any other medications or supplements you’re taking to avoid potential interactions.
  • Side Effects: Desloratadine is generally well-tolerated, but some common side effects may include headache, dry mouth, fatigue, and nausea. If you experience any severe side effects such as difficulty breathing, swelling of the face or throat, or severe dizziness, seek medical attention immediately.

Always consult your healthcare provider for personalized advice regarding the appropriate dosage and usage of Desloratadine based on your individual medical condition.

Other uses for this medicine

Desloratadine is primarily used for the treatment of allergic conditions, particularly allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives). However, it may also have off-label uses or be prescribed for conditions not specifically listed on the medication label. Some of these off-label uses might include relief from symptoms related to allergic conjunctivitis or allergic skin reactions.

What special precautions should I follow?

When using Desloratadine, it’s important to follow certain precautions to ensure safe and effective use. Here are some special precautions to keep in mind:

  • Medical History: Inform your doctor about your complete medical history, especially if you have any liver or kidney disease. Desloratadine may require dosage adjustments in such cases.
  • Allergies: Let your doctor know if you have any known allergies to Desloratadine or other antihistamines. Also, disclose any other allergies you have, including to foods, dyes, or preservatives, as some formulations of Desloratadine may contain inactive ingredients that could cause allergic reactions.
  • Pregnancy and Breastfeeding: If you are pregnant or planning to become pregnant, discuss the risks and benefits of using Desloratadine with your doctor. While Desloratadine is generally considered safe during pregnancy, it’s essential to weigh the potential benefits against any risks. Similarly, if you are breastfeeding, consult your doctor before using Desloratadine, as it may pass into breast milk.
  • Children and Elderly: Use caution when administering Desloratadine to children and elderly individuals. Dosage adjustments may be necessary based on age and overall health status.
  • Driving and Operating Machinery: Desloratadine may cause drowsiness or dizziness in some individuals. If you experience these effects, avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
  • Alcohol and Sedatives: Avoid consuming alcohol or taking sedatives while using Desloratadine, as they may increase drowsiness and dizziness.
  • Interactions: Inform your doctor about all the medications, supplements, and herbal products you are taking, as Desloratadine may interact with certain drugs, including ketoconazole, erythromycin, and other medications that inhibit liver enzymes.
  • Medical Procedures: If you are scheduled for any medical procedures or surgery, inform your healthcare provider that you are taking Desloratadine, as it may interact with certain anesthetic agents.
  • Storage: Store Desloratadine tablets and syrup at room temperature away from moisture and heat. Keep the medication out of reach of children.

Always follow your doctor’s instructions and ask any questions you may have about Desloratadine to ensure safe and effective use. If you experience any unusual symptoms or side effects while using Desloratadine, contact your healthcare provider promptly.

What special dietary instructions should I follow?

Regarding dietary instructions, there are no specific dietary restrictions associated with Desloratadine. You can take it with or without food, as directed by your healthcare provider.

What should I do if I forget a dose?

If you forget to take a dose of Desloratadine, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Desloratadine is generally well-tolerated by most individuals, but like any medication, it can cause side effects in some people. Common side effects of Desloratadine may include:

  • Headache: Mild to moderate headaches are among the most commonly reported side effects.
  • Dry Mouth: Some individuals may experience dryness in the mouth or throat.
  • Fatigue: Although Desloratadine is considered non-sedating for most people, some individuals may experience mild drowsiness or fatigue.
  • Nausea: Some people may experience mild nausea or gastrointestinal discomfort.
  • Sore Throat: A sore throat can occur in some individuals as a side effect of Desloratadine.
  • Muscle Pain: Rarely, Desloratadine may cause muscle pain or myalgia.
  • Dizziness: A feeling of dizziness or lightheadedness may occur in some individuals, particularly when first starting the medication.
  • Nervousness or Restlessness: Some individuals may experience feelings of nervousness or restlessness.
  • Allergic Reactions: While rare, serious allergic reactions to Desloratadine can occur. Seek immediate medical attention if you experience symptoms such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

It’s important to note that this is not a comprehensive list of all possible side effects. Some people may experience other side effects not listed here. Additionally, individual responses to medications can vary, so not everyone will experience the same side effects, and some may experience none at all.

If you experience any bothersome or persistent side effects while taking Desloratadine, contact your healthcare provider for advice. They can help determine whether the side effects are significant and whether any adjustments to your treatment plan are necessary. If you experience severe or life-threatening symptoms, seek immediate medical attention.

What should I know about storage and disposal of this medication?

When it comes to the storage and disposal of Desloratadine:


  • Store Desloratadine at room temperature away from moisture and heat.
  • Keep the medication tightly closed in its original container, out of reach of children and pets.
  • Do not store Desloratadine in the bathroom or near the kitchen sink, where it could be exposed to moisture.
  • Avoid exposing the medication to extreme temperatures, such as freezing or high heat.


  • Dispose of expired or unused Desloratadine properly according to local regulations or guidelines.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
  • Consult your pharmacist or local waste disposal company for guidance on the proper disposal of Desloratadine.

In case of emergency/overdose

  • In case of an overdose, seek emergency medical attention or contact a poison control center immediately.
  • Symptoms of an overdose may include extreme drowsiness, confusion, hallucinations, fast or irregular heartbeat, or seizures.
  • If possible, bring the Desloratadine packaging or container to the healthcare provider or emergency room for identification.

What other information should I know?

  • Inform your healthcare provider about all medications, supplements, or herbal products you are taking, as they may interact with Desloratadine.
  • Follow your healthcare provider’s instructions regarding the use of Desloratadine, including dosage, timing, and duration of treatment.
  • Keep all appointments with your healthcare provider for monitoring and evaluation of your condition.
  • Notify your healthcare provider if your symptoms do not improve or worsen while taking Desloratadine.
  • Do not share Desloratadine with others, even if they have similar symptoms, as it may not be appropriate for their condition.

By following these guidelines for storage, disposal, and what to do in case of emergency, you can help ensure the safe and effective use of Desloratadine. If you have any questions or concerns, don’t hesitate to consult your healthcare provider or pharmacist for guidance.

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